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Gprin3 Gene Detail
Summary
  • Symbol
    Gprin3
  • Name
    GPRIN family member 3
  • Synonyms
    C030038J10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924785
    NCBI Gene: 243385
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:59347226-59426294 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 28.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924785
protein coding gene Chr6:59344500-59426306 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030822
protein coding gene Chr6:58979631-59062168 (-)
A/J MGP_AJ_G0030789
protein coding gene Chr6:56439626-56520276 (-)
AKR/J MGP_AKRJ_G0030717
protein coding gene Chr6:58288812-58373778 (-)
BALB/cJ MGP_BALBcJ_G0030801
protein coding gene Chr6:56725665-56805992 (-)
C3H/HeJ MGP_C3HHeJ_G0030515
protein coding gene Chr6:58268933-58350833 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031259
protein coding gene Chr6:60266352-60356037 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028451
protein coding gene Chr6:53437975-53519869 (-)
CAST/EiJ MGP_CASTEiJ_G0029913
protein coding gene Chr6:57943663-58028339 (-)
CBA/J MGP_CBAJ_G0030488
protein coding gene Chr6:62775426-62857646 (-)
DBA/2J MGP_DBA2J_G0030639
protein coding gene Chr6:56134189-56216619 (-)
FVB/NJ MGP_FVBNJ_G0030592
protein coding gene Chr6:55681708-55759919 (-)
LP/J MGP_LPJ_G0030724
protein coding gene Chr6:58909827-58990763 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030627
protein coding gene Chr6:65475853-65562532 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031285
protein coding gene Chr6:58148676-58232265 (-)
PWK/PhJ MGP_PWKPhJ_G0029628
protein coding gene Chr6:55890385-55974729 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029455
protein coding gene Chr6:57365989-57449009 (-)
WSB/EiJ MGP_WSBEiJ_G0029994
protein coding gene Chr6:58342851-58427918 (-)



Homology
more
  • Human Ortholog
    GPRIN3, GPRIN family member 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GPRIN3, GPRIN family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GRIN3
  • Links
    NCBI Gene ID: 285513
    neXtProt AC: NX_Q6ZVF9
    UniProt: Q6ZVF9

  • Chr Location
    4q22.1; chr4:89237666-89308010 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased motivation for reward, decreased locomotor response to cocaine, increased dendritic arborization of medium spiny neurons and decreased striatal neuron excitability.
Gene Ontology
(GO)
Classifications
less
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045441 Ensembl Gene Model | MGI Sequence Detail 79069 C57BL/6J ±  kb
transcript ENSMUST00000051065 Ensembl | MGI Sequence Detail 8339 Not Applicable  
polypeptide ENSMUSP00000051805 Ensembl | MGI Sequence Detail 763 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008201 G protein-regulated inducer of neurite outgrowth 3
  • InterPro Domains
    IPR026646 G protein-regulated inducer of neurite outgrowth
    IPR032745 G protein-regulated inducer of neurite outgrowth, C-terminal
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 20
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:279507 Karadurmus D, et al., GPRIN3 Controls Neuronal Excitability, Morphology, and Striatal-Dependent Behaviors in the Indirect Pathway of the Striatum. J Neurosci. 2019 Sep 18;39(38):7513-7528

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory