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Anks1b Gene Detail
Summary
  • Symbol
    Anks1b
  • Name
    ankyrin repeat and sterile alpha motif domain containing 1B
  • Synonyms
    AIDA-1b, C030032C09Rik, E530015N03Rik, Gm10937, LOC380650
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924781
    NCBI Gene: 77531
  • Gene Overview
    MyGene.info: ANKS1B
Location & Maps
more
  • Sequence Map
    Chr10:89873509-90973300 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1099792 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 45.28 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ANKS1B, ankyrin repeat and sterile alpha motif domain containing 1B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ANKS1B, ankyrin repeat and sterile alpha motif domain containing 1B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AIDA, AIDA-1, ANKS2, cajalin-2, EB1, EB-1
  • Links
    NCBI Gene ID: 56899
    neXtProt AC: NX_Q7Z6G8

  • Chr Location
    12q23.1; chr12:98729904-99984727 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Transposon induced
    1
  • Genomic Mutations
    2 involving Anks1b
  • Incidental Mutations
Mice homozygous for a conditional allele activated in neurons alters hippocampal synaptic transmission.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043484 VEGA Gene Model | MGI Sequence Detail 1099792 C57BL/6J ±  kb
transcript OTTMUST00000114026 VEGA | MGI Sequence Detail 4248 Not Applicable  
polypeptide OTTMUSP00000063640 VEGA | MGI Sequence Detail 1259 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8682 from dbSNP Build 142
Protein
Information
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  • UniProt
    28 Sequences
  • Protein Ontology
    PR:000004052 ankyrin repeat and sterile alpha motif domain-containing protein 1B
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR033635 Ankyrin repeat and SAM domain-containing protein 1
    IPR033636 Ankyrin repeat and SAM domain-containing protein 1B
    IPR020683 Ankyrin repeat-containing domain
    IPR011993 PH domain-like
    IPR006020 PTB/PI domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 11
Other
Accession IDs
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MGI:2686401, MGI:3779147
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222552 Tindi JO, et al., ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization. J Neurosci. 2015 Jun 17;35(24):8986-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory