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Zfyve26 Gene Detail
Summary
  • Symbol
    Zfyve26
  • Name
    zinc finger, FYVE domain containing 26
  • Synonyms
    9330197E15Rik, A630028O16Rik, LOC380767
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924767
    NCBI Gene: 211978
  • Gene Overview
    MyGene.info: ZFYVE26
Location & Maps
more
  • Sequence Map
    Chr12:79232347-79296282 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63936 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZFYVE26, zinc finger FYVE-type containing 26
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFYVE26, zinc finger FYVE-type containing 26
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FYVE-CENT, SPG15
  • Links
    NCBI Gene ID: 23503
    neXtProt AC: NX_Q68DK2

  • Chr Location
    14q24.1; chr14:67729569-67816611 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Zfyve26 mouse models; 1 with human ZFYVE26 associations

Human Disease Mouse Models
       Spastic Paraplegia 15, Autosomal Recessive; SPG15   OMIM: 270700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    5 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    9
  • Targeted
    1
  • Genomic Mutations
    1 involving Zfyve26
  • Incidental Mutations
Mice homozygoys for a null allele display a late-onset spastic gait disorder with cerebellar ataxia, axon degeneration, and progressive loss of cortical motoneurons and Purkinje cells preceded by accumulation of autofluorescent, electron-dense, membrane-enclosed material in lysosomal structures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066440 Ensembl Gene Model | MGI Sequence Detail 63936 C57BL/6J ±  kb
transcript ENSMUST00000021547 Ensembl | MGI Sequence Detail 9368 Not Applicable  
polypeptide ENSMUSP00000021547 Ensembl | MGI Sequence Detail 2529 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    470 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000032762 zinc finger FYVE domain-containing protein 26
  • InterPro Domains
    IPR000306 FYVE zinc finger
    IPR028730 Zinc finger FYVE domain-containing protein 26
    IPR011011 Zinc finger, FYVE/PHD-type
    IPR017455 Zinc finger, FYVE-related
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
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  • All nucleic 70
    cDNA 70

    Microarray probesets 3
Other
Accession IDs
less
MGI:2685739
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:223127 Khundadze M, et al., A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system. PLoS Genet. 2013;9(12):e1003988

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory