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Tmem116 Gene Detail
Summary
  • Symbol
    Tmem116
  • Name
    transmembrane protein 116
  • Synonyms
    4930406A18Rik, 4930513P12Rik, C030022K24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924712
    NCBI Gene: 77462
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121452709-121517910 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 61.81 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924712
protein coding gene Chr5:121451893-121524183 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030028
protein coding gene Chr5:124936878-125017001 (+)
A/J MGP_AJ_G0029993
protein coding gene Chr5:119793700-119868089 (+)
AKR/J MGP_AKRJ_G0029930
protein coding gene Chr5:123669028-123744410 (+)
BALB/cJ MGP_BALBcJ_G0030004
protein coding gene Chr5:121177264-121254590 (+)
C3H/HeJ MGP_C3HHeJ_G0029722
protein coding gene Chr5:124233323-124312300 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030457
protein coding gene Chr5:129696164-129775409 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027683
protein coding gene Chr5:114475029-114536357 (+)
CAST/EiJ MGP_CASTEiJ_G0029130
protein coding gene Chr5:123345766-123421923 (+)
CBA/J MGP_CBAJ_G0029691
protein coding gene Chr5:134793850-134880026 (+)
DBA/2J MGP_DBA2J_G0029841
protein coding gene Chr5:119864872-119937474 (+)
FVB/NJ MGP_FVBNJ_G0029798
protein coding gene Chr5:118812893-118892892 (+)
LP/J MGP_LPJ_G0029930
protein coding gene Chr5:125454782-125530538 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029828
protein coding gene Chr5:138653435-138731758 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030498
protein coding gene Chr5:123184317-123266154 (+)
PWK/PhJ MGP_PWKPhJ_G0028844
protein coding gene Chr5:118635601-118714170 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028681
protein coding gene Chr5:120949420-121024370 (+)
WSB/EiJ MGP_WSBEiJ_G0029205
protein coding gene Chr5:123840093-123920443 (+)



Homology
more
  • Human Ortholog
    TMEM116, transmembrane protein 116
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TMEM116, transmembrane protein 116
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 89894
    neXtProt AC: NX_Q8NCL8
    UniProt: Q8NCL8

  • Chr Location
    12q24.12-q24.13; chr12:111894936-112013219 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 77462 NCBI Gene Model | MGI Sequence Detail 65202 C57BL/6J ±  kb
transcript NM_001161627 RefSeq | MGI Sequence Detail 1364 C57BL/6  
polypeptide NP_001155099 RefSeq | MGI Sequence Detail 364 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • InterPro Domains
    IPR022343 GCR1-cAMP receptor
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 4
Other
Accession IDs
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MGI:1918908, MGI:1921049
References
more
  • Summaries
    All 30
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory