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Heg1
Gene Detail
Symbol

Name
ID
Heg1
HEG homolog 1 (zebrafish)
MGI:1924696
Synonyms
4632417D23Rik, 5530401I02Rik, 9530025L16Rik, LOC268884
Feature Type
protein coding gene
Genetic Map
Chromosome 16
24.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:33684466-33771576 bp, + strand
From VEGA annotation of GRCm38

  87111 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Heg1

Human
homologs
Human Homolog HEG1, heart development protein with EGF-like domains 1
NCBI Gene ID 57493
neXtProt AC  NX_Q9ULI3
Human Synonyms  HEG, MST112, MSTP112
Human Chr (Location)  3q21.2; chr3:124965710-125055958 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display partial penetrance of prenatal and postnatal lethality with abnormal heart development, henorrhages, and leaky lymphatic vessels.
 
Interactions
Heg1 interacts with 408 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cardiac atrium morphogenesis, cardiac muscle tissue growth, ...
Component cell-cell junction, cell junction, ...
Function calcium ion binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (42)    Tissues (4)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027314 (Evidence)
Ensembl Gene ModelENSMUSG00000075254 (Evidence)
Entrez Gene77446 (Evidence)
DFCITC1582379, TC1584922, TC1587452, TC1597933, TC1717146
DoTSDT.60102246, DT.102545955, DT.55202675, DT.97397554
NIA Mouse Gene IndexU017042, U017044
Consensus CDS ProjectCCDS28132.1, CCDS28133.1
International Mouse Knockout Project StatusHeg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027314 VEGA Gene Model | MGI Sequence Detail 87111 C57BL/6J ±  kb
transcript OTTMUST00000082992 VEGA | MGI Sequence Detail 6714 Not Applicable 
polypeptide OTTMUSP00000044536 VEGA | MGI Sequence Detail 1337 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(13) UniProt(7)
Polymorphisms
SNPs within 2kb(865 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
Protein Ontology PR:000008505 protein HEG homolog 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187714 Zheng X, et al., Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Dev Cell. 2012 Aug 14;23(2):342-55
All references(30)
Other
accession IDs
MGI:1918609, MGI:2685475, MGI:3039595, MGI:3606087, MGI:3801754

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory