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Esrp2 Gene Detail
Summary
  • Symbol
    Esrp2
  • Name
    epithelial splicing regulatory protein 2
  • Synonyms
    9530027K23Rik, Rbm35b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924661
    NCBI Gene: 77411
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106130634-106137006 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924661
 protein coding gene Chr8:106130319-106137006 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034076
 protein coding gene Chr8:108473979-108480634 (-)
A/J MGP_AJ_G0034057
 protein coding gene Chr8:104138730-104145385 (-)
AKR/J MGP_AKRJ_G0033983
 protein coding gene Chr8:107147154-107153809 (-)
BALB/cJ MGP_BALBcJ_G0034050
 protein coding gene Chr8:104319806-104326461 (-)
C3H/HeJ MGP_C3HHeJ_G0033762
 protein coding gene Chr8:107886434-107893089 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034570
 protein coding gene Chr8:112453367-112460022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031512
 protein coding gene Chr8:97269008-97275656 (-)
CAST/EiJ MGP_CASTEiJ_G0033088
 protein coding gene Chr8:107413220-107419875 (-)
CBA/J MGP_CBAJ_G0033735
 protein coding gene Chr8:116066426-116073081 (-)
DBA/2J MGP_DBA2J_G0033890
 protein coding gene Chr8:103475347-103482002 (-)
FVB/NJ MGP_FVBNJ_G0033835
 protein coding gene Chr8:102408733-102415388 (-)
LP/J MGP_LPJ_G0033981
 protein coding gene Chr8:108685564-108692219 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033879
 protein coding gene Chr8:119253467-119260122 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034588
 protein coding gene Chr8:107114544-107121199 (-)
PWK/PhJ MGP_PWKPhJ_G0032789
 protein coding gene Chr8:102887166-102895777 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032630
 protein coding gene Chr8:105809873-105816537 (-)
WSB/EiJ MGP_WSBEiJ_G0033204
 protein coding gene Chr8:107801463-107808118 (-)



Homology
more
  • Human Ortholog
    ESRP2, epithelial splicing regulatory protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ESRP2, epithelial splicing regulatory protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RBM35B
  • Links
    NCBI Gene ID: 80004
    neXtProt AC: NX_Q9H6T0
    UniProt: Q9H6T0

  • Chr Location
    16q22.1; chr16:68228547-68236233 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    32 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit defects in hepatic maturation, and decreased serum albumin levels and total serum protein levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    273
  • Tissues
    96
  • cDNA Data
    70
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77411 NCBI Gene Model | MGI Sequence Detail 6373 C57BL/6J ±  kb
    transcript NM_176838 RefSeq | MGI Sequence Detail 2686 FVB/N  
    polypeptide Q8K0G8 UniProt | EBI | MGI Sequence Detail 717 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 70
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:250667 Heilmann K, et al., Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with prognostic relevance for human breast cancer. Oncogene. 2017 Nov 16;36(46):6446-6461
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/13/2019
    MGI 6.13     		The Jackson Laboratory