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Rab35 Gene Detail
Summary
  • Symbol
    Rab35
  • Name
    RAB35, member RAS oncogene family
  • Synonyms
    9530019H02Rik, H-ray, RAB1C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924657
    NCBI Gene: 77407
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115769953-115785217 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924657
 protein coding gene Chr5:115769953-115785795 (+)
129S1/SvImJ ENSMUSG00200022313
 protein coding gene Chr5:109510573-109526401 (+)
A/J ENSMUSG00195033226
 protein coding gene Chr5:109032192-109048029 (+)
AKR/J ENSMUSG00220049241
 protein coding gene Chr5:108539985-108555813 (+)
BALB/cJ ENSMUSG00180042426
 protein coding gene Chr5:109161355-109177184 (+)
C3H/HeJ ENSMUSG00175045412
 protein coding gene Chr5:111147838-111163666 (+)
C57BL/6NJ ENSMUSG00215016627
 protein coding gene Chr5:109170985-109186814 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027632
 protein coding gene Chr5:108583587-108599294 (+)
CAST/EiJ ENSTCUG00005029332
 protein coding gene Chr5:108348206-108363946 (+)
CBA/J ENSMUSG00210031766
 protein coding gene Chr5:109899228-109915056 (+)
DBA/2J ENSMUSG00185051660
 protein coding gene Chr5:112959357-112975185 (+)
FVB/NJ ENSMUSG00205050947
 protein coding gene Chr5:108797829-108813646 (+)
JF1/MsJ ENSUMUG00000040693
 protein coding gene Chr5:115783209-115798920 (+)
LP/J ENSMUSG00230048585
 protein coding gene Chr5:117048727-117064555 (+)
NOD/ShiLtJ ENSMUSG00190026006
 protein coding gene Chr5:108836688-108852516 (+)
NZO/HlLtJ ENSMUSG00225013195
 protein coding gene Chr5:124708727-124724555 (+)
PWK/PhJ ENSLUMG00010024156
 protein coding gene Chr5:107679271-107694992 (+)
SPRET/EiJ ENSMSPG00010035647
 protein coding gene Chr5:110963340-110979209 (+)
WSB/EiJ ENSIUOG00005037944
 protein coding gene Chr5:111540663-111556459 (+)



Homology
more
  • Human Ortholog
    RAB35, RAB35, member RAS oncogene family
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB35, RAB35, member RAS oncogene family
  • Synonyms
    H-ray, RAB1C, RAY
  • Links
    NCBI Gene ID: 11021
    UniProt: Q15286

  • Chr Location
    12q24.23; chr12:120095094-120117502 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout in Schwann cells results in both myelin degradation and focal hypermyelination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    611
  • Tissues
    8
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77407 NCBI Gene Model | MGI Sequence Detail 15265 C57BL/6J ±  kb
    transcript NM_198163 RefSeq | MGI Sequence Detail 2181 C57BL/6  
    polypeptide Q6PHN9 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141075
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 3
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353484 Clearman KR, et al., Rab35 Is Required for Embryonic Development and Kidney and Ureter Homeostasis through Regulation of Epithelial Cell Junctions. J Am Soc Nephrol. 2024 Jun 1;35(6):719-732
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory