About   Help   FAQ
Sec24a Gene Detail
Summary
  • Symbol
    Sec24a
  • Name
    Sec24 related gene family, member A (S. cerevisiae)
  • Synonyms
    9430090N21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924621
    NCBI Gene: 77371
  • Gene Overview
    MyGene.info: SEC24A
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:51692263-51757280 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924621
 protein coding gene Chr11:51692263-51763634 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018275
 protein coding gene Chr11:50946167-51032022 (-)
A/J MGP_AJ_G0018244
 protein coding gene Chr11:49027077-49101980 (-)
AKR/J MGP_AKRJ_G0018214
 protein coding gene Chr11:50564808-50644503 (-)
BALB/cJ MGP_BALBcJ_G0018215
 protein coding gene Chr11:49319223-49401331 (-)
C3H/HeJ MGP_C3HHeJ_G0018026
 protein coding gene Chr11:50602775-50676735 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018665
 protein coding gene Chr11:52490516-52569636 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016317
 protein coding gene Chr11:46586692-46659221 (-)
CAST/EiJ MGP_CASTEiJ_G0017590
 protein coding gene Chr11:50590270-50672252 (-)
CBA/J MGP_CBAJ_G0018001
 protein coding gene Chr11:54945989-55039396 (-)
DBA/2J MGP_DBA2J_G0018108
 protein coding gene Chr11:48733282-48805113 (-)
FVB/NJ MGP_FVBNJ_G0018103
 protein coding gene Chr11:48449766-48523482 (-)
LP/J MGP_LPJ_G0018184
 protein coding gene Chr11:51365673-51444327 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018126
 protein coding gene Chr11:56360093-56443189 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018708
 protein coding gene Chr11:50666497-50747473 (-)
PWK/PhJ MGP_PWKPhJ_G0017366
 protein coding gene Chr11:49251647-49329597 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017161
 protein coding gene Chr11:50400367-50479058 (-)
WSB/EiJ MGP_WSBEiJ_G0017638
 protein coding gene Chr11:50311400-50388188 (-)



Homology
more
  • Human Ortholog
    SEC24A, SEC24 homolog A, COPII coat complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEC24A, SEC24 homolog A, COPII coat complex component
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 10802
    neXtProt AC: NX_O95486
    UniProt: O95486

  • Chr Location
    5q31.1; chr5:134648402-134727911 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased circulating cholesterol level, decreased circulating LDL cholesterol level, and abnormal liver physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
    2
  • Tissues
    2
  • cDNA Data
    58
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77371 NCBI Gene Model | MGI Sequence Detail 65018 C57BL/6J ±  kb
    transcript NM_175255 RefSeq | MGI Sequence Detail 6798 C57BL/6  
    polypeptide Q3U2P1 UniProt | EBI | MGI Sequence Detail 1090 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 58
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2144209
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265679 Wang B, et al., The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest. 2018 Aug 1;128(8):3319-3332
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    01/08/2019
    MGI 6.13     		The Jackson Laboratory