Sec24a
Gene Detail

Symbol Name ID

Sec24a Sec24 related gene family, member A (S. cerevisiae) MGI:1924621

Synonyms

9430090N21Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

31.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:51692264-51763634 bp, - strand From VEGA annotation of GRCm38   71371 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:70131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vesicle coat complex COPII, subunit SEC24
Gene Tree: Sec24a

Human homologs

Human Homolog		SEC24A, SEC24 family member A
NCBI Gene ID		10802
neXtProt AC		NX_O95486
Human Chr (Location)		5q31.1; chr5:134648785-134727911 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(38) : Gene trapped(36) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Sec24a interacts with 371 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	ER to Golgi vesicle-mediated transport, intracellular protein transport, ...
Component	COPII vesicle coat, cytoplasm, ...
Function	zinc ion binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)

cDNA source data(57)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(57) cDNA(57)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000005603 (Evidence)
Ensembl Gene Model	ENSMUSG00000036391 (Evidence)
Entrez Gene	77371 (Evidence)
UniGene	33878
DFCI	TC1581548, TC1586961, TC1602419, TC1612592, TC1665760, TC1679329
DoTS	DT.110512117, DT.87047916, DT.87055065, DT.91351011, DT.91381226
NIA Mouse Gene Index	U032744
Consensus CDS Project	CCDS24660.2, CCDS70181.1
International Mouse Knockout Project Status	Sec24a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005603	VEGA Gene Model | MGI Sequence Detail	71371	C57BL/6J
transcript	OTTMUST00000012466	VEGA | MGI Sequence Detail	6581	Not Applicable
polypeptide	OTTMUSP00000005765	VEGA | MGI Sequence Detail	1090	Not Applicable

All sequences(66) RefSeq(7) UniProt(6)

Polymorphisms

SNPs within 2kb(209 from dbSNP Build 137)    SNPs within 2kb including multiple locations(211)

Protein-related information

Resource	ID	Description
InterPro	IPR007123	Gelsolin domain
InterPro	IPR012990	Sec23/Sec24 beta-sandwich
InterPro	IPR006900	Sec23/Sec24, helical domain
InterPro	IPR006896	Sec23/Sec24, trunk domain
InterPro	IPR002035	von Willebrand factor, type A
InterPro	IPR006895	Zinc finger, Sec23/Sec24-type
Protein Ontology	PR:000014589	protein transport protein Sec24A

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198477 Chen XW, et al., SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. Elife. 2013;2:e00444
All references(38)

Other accession IDs

MGI:2144209