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Sec24a Gene Detail
Summary
  • Symbol
    Sec24a
  • Name
    Sec24 related gene family, member A (S. cerevisiae)
  • Synonyms
    9430090N21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924621
    NCBI Gene: 77371
  • Gene Overview
    MyGene.info: SEC24A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:51692264-51763634 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71371 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.28 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SEC24A, SEC24 homolog A, COPII coat complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEC24A, SEC24 homolog A, COPII coat complex component
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 10802
    neXtProt AC: NX_O95486
    UniProt: O95486

  • Chr Location
    5q31.1; chr5:134648402-134727911 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased circulating cholesterol level, decreased circulating LDL cholesterol level, and abnormal liver physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005603 VEGA Gene Model | MGI Sequence Detail 71371 C57BL/6J ±  kb
    transcript OTTMUST00000012466 VEGA | MGI Sequence Detail 6581 Not Applicable  
    polypeptide OTTMUSP00000005765 VEGA | MGI Sequence Detail 1090 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      207 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 57
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2144209
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory