Sec24a MGI Mouse Gene Detail - MGI:1924621 - Sec24 related gene family, member A (S. cerevisiae)

Symbol

Sec24a
Name

Sec24 related gene family, member A (S. cerevisiae)
Synonyms

9430090N21Rik

Feature Type

protein coding gene
IDs

MGI:1924621
NCBI Gene: 77371
Gene Overview

MyGene.info: SEC24A
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:51692263-51757161 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 31.28 cM
Mapping Data

2 experiments

SNPs within 2kb

188 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924621	protein coding gene	Chr11:51692263-51763634 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018275	protein coding gene	Chr11:50946167-51032022 (-)
A/J	MGP_AJ_G0018244	protein coding gene	Chr11:49027077-49101980 (-)
AKR/J	MGP_AKRJ_G0018214	protein coding gene	Chr11:50564808-50644503 (-)
BALB/cJ	MGP_BALBcJ_G0018215	protein coding gene	Chr11:49319223-49401331 (-)
C3H/HeJ	MGP_C3HHeJ_G0018026	protein coding gene	Chr11:50602775-50676735 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018665	protein coding gene	Chr11:52490516-52569636 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016317	protein coding gene	Chr11:46586692-46659221 (-)
CAST/EiJ	MGP_CASTEiJ_G0017590	protein coding gene	Chr11:50590270-50672252 (-)
CBA/J	MGP_CBAJ_G0018001	protein coding gene	Chr11:54945989-55039396 (-)
DBA/2J	MGP_DBA2J_G0018108	protein coding gene	Chr11:48733282-48805113 (-)
FVB/NJ	MGP_FVBNJ_G0018103	protein coding gene	Chr11:48449766-48523482 (-)
LP/J	MGP_LPJ_G0018184	protein coding gene	Chr11:51365673-51444327 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018126	protein coding gene	Chr11:56360093-56443189 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018708	protein coding gene	Chr11:50666497-50747473 (-)
PWK/PhJ	MGP_PWKPhJ_G0017366	protein coding gene	Chr11:49251647-49329597 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017161	protein coding gene	Chr11:50400367-50479058 (-)
WSB/EiJ	MGP_WSBEiJ_G0017638	protein coding gene	Chr11:50311400-50388188 (-)

Human Ortholog

SEC24A, SEC24 homolog A, COPII coat complex component

Vertebrate Orthologs

10

Human Ortholog

SEC24A, SEC24 homolog A, COPII coat complex component
Orthology source: HomoloGene, HGNC
Links

HGNC:10703

NCBI Gene ID: 10802

neXtProt AC: NX_O95486

UniProt: O95486
Chr Location

5q31.1; chr5:134648402-134727911 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 70131
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SEC24A
Protein SuperFamily

vesicle coat complex COPII, subunit SEC24
Gene Tree

Sec24a

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Gene trapped

35
Targeted

4
Genomic Mutations

1 involving Sec24a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased circulating cholesterol level, decreased circulating LDL cholesterol level, and abnormal liver physiology.

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All GO Annotations

15
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

633
Tissues

2
cDNA Data

58
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sec24a

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Sec24a interacts with 370 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

64
RefSeq

9
UniProt

6
CCDS

CCDS24660.2, CCDS70181.1
UniGene

33878

Ensembl

ENSMUSG00000036391 (Evidence)
NCBI Gene

77371

			Length	Strain/Species	Flank
genomic	77371	NCBI Gene Model \| MGI Sequence Detail	64899	C57BL/6J	± kb
transcript	NM_175255	RefSeq \| MGI Sequence Detail	6798	C57BL/6
polypeptide	Q3U2P1	UniProt \| EBI \| MGI Sequence Detail	1090	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014589 protein transport protein Sec24A

(term hierarchy)
InterPro Domains

IPR029006 ADF-H/Gelsolin-like domain superfamily

IPR007123 Gelsolin-like domain

IPR036180 Gelsolin-like domain superfamily

IPR012990 Sec23/Sec24 beta-sandwich

IPR006900 Sec23/Sec24, helical domain

IPR036175 Sec23/Sec24 helical domain superfamily

IPR006896 Sec23/Sec24, trunk domain

IPR041742 Sec24-like, trunk domain

IPR036465 von Willebrand factor A-like domain superfamily

IPR006895 Zinc finger, Sec23/Sec24-type

IPR036174 Zinc finger, Sec23/Sec24-type superfamily

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All nucleic 59

cDNA 58

Other 1

Microarray probesets 2

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MGI:2144209

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:265679 Wang B, et al., The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest. 2018 Aug 1;128(8):3319-3332

TSS for Sec24a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107827	Chr11:51763596-51763637 (-)	-6,456 bp
Tssr107826	Chr11:51756378-51756493 (-)	725 bp
Tssr3489	Chr11:51755656-51755666 (-)	1,500 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/19/2020 MGI 6.15