Sec24a Gene Detail

Summary

• Symbol
  Sec24a
• Name
  Sec24 related gene family, member A (S. cerevisiae)
• Synonyms
  9430090N21Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1924621
  NCBI Gene: 77371
• Gene Overview
  MyGene.info: SEC24A

Location & Maps

• Sequence Map
  Chr11:51692264-51763634 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    71371 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 31.28 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  SEC24A, SEC24 homolog A, COPII coat complex component

• Vertebrate Orthologs
  10

• Human Ortholog
  SEC24A, SEC24 homolog A, COPII coat complex component
  Orthology source: HomoloGene, HGNC
• Links
  HGNC:10703

  NCBI Gene ID: 10802

  neXtProt AC: NX_O95486

  UniProt: O95486

  
  
• Chr Location
  5q31.1; chr5:134648402-134727911 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 70131
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: SEC24A
• Protein SuperFamily
  vesicle coat complex COPII, subunit SEC24
• Gene Tree
  Sec24a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotypes from 1 allele in 2 genetic backgrounds
  12 phenotype references
  

• All Mutations and Alleles
  39
• Chemically induced (other)
  1
• Gene trapped
  36
• Targeted
  2
• Genomic Mutations
  1 involving Sec24a
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  52 strains or lines available

Mice homozygous for a null allele exhibit decreased circulating cholesterol level, decreased circulating LDL cholesterol level, and abnormal liver physiology.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  14
• GO References
  3

• External Resources
  FuncBase

Expression

• Assay Results
  2
• Tissues
  2
• cDNA Data
  57
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase sec24a

Interactions

• Sec24a interacts with 370 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

Sequences &
Gene Models

• All Sequences
  57
• RefSeq
  9
• UniProt
  6
• CCDS
  CCDS24660.2, CCDS70181.1
• UniGene
  33878

• VEGA
  OTTMUSG00000005603 (Evidence)
• Ensembl
  ENSMUSG00000036391 (Evidence)
• NCBI Gene
  77371

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000005603	VEGA Gene Model | MGI Sequence Detail	71371	C57BL/6J
transcript	OTTMUST00000012466	VEGA | MGI Sequence Detail	6581	Not Applicable
polypeptide	OTTMUSP00000005765	VEGA | MGI Sequence Detail	1090	Not Applicable

Polymorphisms

• SNPs within 2kb
  207 from dbSNP Build 142

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000014589 protein transport protein Sec24A
  (term hierarchy)
• InterPro Domains
  IPR029006 ADF-H/Gelsolin-like domain
  IPR007123 Gelsolin-like domain
  IPR012990 Sec23/Sec24 beta-sandwich
  IPR006900 Sec23/Sec24, helical domain
  IPR006896 Sec23/Sec24, trunk domain
  IPR002035 von Willebrand factor, type A
  IPR006895 Zinc finger, Sec23/Sec24-type

Molecular
Reagents

• All nucleic 58

  cDNA 57

  Other 1

  
  

  Microarray probesets 2

Other
Accession IDs

MGI:2144209

References

• Summaries
  All 37

  Developmental Gene Expression 1

  Gene Ontology 3

  Phenotypes 12
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24