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Akr1c21
Gene Detail
 Symbol
Name
ID
Akr1c21
aldo-keto reductase family 1, member C21
MGI:1924587
Synonyms 9430025F20Rik
Feature Type protein coding gene
Genetic Map
Chromosome 13
2.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:4574075-4586541 bp, + strand
From VEGA annotation of GRCm38

  12467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110860  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: AKR
Gene Tree: Akr1c21

Human
homologs
Human Homolog AKR1C1, aldo-keto reductase family 1, member C1
NCBI Gene ID 1645
neXtProt AC  NX_Q04828
Human Synonyms  20-ALPHA-HSD, 2-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
Human Chr (Location)  10p15-p14; chr10:4963262-4977966 (+)  GRCh38
Human Homolog AKR1C2, aldo-keto reductase family 1, member C2
NCBI Gene ID 1646
neXtProt AC  NX_P52895
Human Synonyms  AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
Human Chr (Location)  10p15-p14; chr10:4987775-5018033 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process G-protein coupled receptor signaling pathway, lipid metabolic process, ...
Component cytoplasm, cytosol
Function alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(165)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(166) cDNA(166)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027696 (Evidence)
Ensembl Gene ModelENSMUSG00000021207 (Evidence)
Entrez Gene77337 (Evidence)
UniGene27085
DFCITC1575431
DoTSDT.492139
NIA Mouse Gene IndexU014514
EC1.1.1.-, 1.1.1.209
PDB2HEJ, 2IPF, 2IPG, 2P5N, 3FJN, 2HE5, 2HE8, 3CV6
Consensus CDS ProjectCCDS26225.1
International Mouse Knockout Project StatusAkr1c21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027696 VEGA Gene Model | MGI Sequence Detail 12467 C57BL/6J ±  kb
transcript OTTMUST00000068534 VEGA | MGI Sequence Detail 1207 Not Applicable 
polypeptide OTTMUSP00000034678 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001395 Aldo/keto reductase
InterPro IPR018170 Aldo/keto reductase, conserved site
InterPro IPR020471 Aldo/keto reductase subgroup
InterPro IPR023210 NADP-dependent oxidoreductase domain
Protein Ontology PR:000004561 aldo-keto reductase family 1 member C21
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)
Other
accession IDs
MGI:2145202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory