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Akr1c21 Gene Detail
Summary
  • Symbol
    Akr1c21
  • Name
    aldo-keto reductase family 1, member C21
  • Synonyms
    9430025F20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924587
    NCBI Gene: 77337
Location & Maps
more
  • Sequence Map
    Chr13:4574075-4586541 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12467 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1, member C1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1, member C1
    Orthology source: HomoloGene
  • Synonyms
    20-ALPHA-HSD, 2-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
  • Links
    NCBI Gene ID: 1645
    neXtProt AC: NX_Q04828

  • Chr Location
    10p15-p14; chr10:4963262-4977966 (+)  GRCh38.p2

  • Human Ortholog
    AKR1C2, aldo-keto reductase family 1, member C2
    Orthology source: HomoloGene
  • Synonyms
    AKR1C-pseudo, BABP, DD, DD2, DD-2, DD/BABP, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
  • Links
    NCBI Gene ID: 1646
    neXtProt AC: NX_P52895

  • Chr Location
    10p15-p14; chr10:4987775-5018033 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human AKR1C2 associations

Human Disease Mouse Models
       46,xy Sex Reversal 8; SRXY8   OMIM: 614279
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027696 VEGA Gene Model | MGI Sequence Detail 12467 C57BL/6J ±  kb
transcript OTTMUST00000068534 VEGA | MGI Sequence Detail 1207 Not Applicable  
polypeptide OTTMUSP00000034678 VEGA | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    141 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 166
    cDNA 166

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145202
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory