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Akr1c21 Gene Detail
Summary
  • Symbol
    Akr1c21
  • Name
    aldo-keto reductase family 1, member C21
  • Synonyms
    9430025F20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924587
    NCBI Gene: 77337
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:4574075-4586541 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 2.56 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924587
protein coding gene Chr13:4574075-4586543 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020209
protein coding gene Chr13:1052182-1065267 (+)
A/J MGP_AJ_G0020165
protein coding gene Chr13:1150741-1166968 (+)
AKR/J MGP_AKRJ_G0020140
protein coding gene Chr13:1198304-1210770 (+)
BALB/cJ MGP_BALBcJ_G0020148
protein coding gene Chr13:1160599-1178109 (+)
C3H/HeJ MGP_C3HHeJ_G0019952
protein coding gene Chr13:1268100-1280566 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020595
protein coding gene Chr13:1171869-1184335 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0019492
protein coding gene Chr13:1081129-1101087 (+)
CBA/J MGP_CBAJ_G0019919
protein coding gene Chr13:1164795-1177261 (+)
DBA/2J MGP_DBA2J_G0020036
protein coding gene Chr13:1062615-1075672 (+)
FVB/NJ MGP_FVBNJ_G0020021
protein coding gene Chr13:1019205-1031844 (+)
LP/J MGP_LPJ_G0020110
protein coding gene Chr13:1162351-1181294 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020057
protein coding gene Chr13:1280871-1295953 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020623
protein coding gene Chr13:1143913-1156367 (+)
PWK/PhJ MGP_PWKPhJ_G0019253
protein coding gene Chr13:1144880-1157486 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019060
protein coding gene Chr13:1200349-1212719 (+)
WSB/EiJ MGP_WSBEiJ_G0019550
protein coding gene Chr13:1084117-1096565 (+)



Homology
more
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
    Orthology source: HomoloGene
  • Synonyms
    20-ALPHA-HSD, 2-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
  • Links
    NCBI Gene ID: 1645
    neXtProt AC: NX_Q04828
    UniProt: Q04828

  • Chr Location
    10p15.1; chr10:4963262-4979967 (+)  GRCh38.p7

  • Human Ortholog
    AKR1C2, aldo-keto reductase family 1 member C2
    Orthology source: HomoloGene
  • Synonyms
    AKR1C-pseudo, BABP, DD, DD2, DD-2, DD/BABP, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
  • Links
    NCBI Gene ID: 1646
    neXtProt AC: NX_P52895
    UniProt: P52895

  • Chr Location
    10p15.1; chr10:4987775-5018033 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human AKR1C2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021207 Ensembl Gene Model | MGI Sequence Detail 12467 C57BL/6J ±  kb
transcript ENSMUST00000021628 Ensembl | MGI Sequence Detail 1207 Not Applicable  
polypeptide ENSMUSP00000021628 Ensembl | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 166
    cDNA 166

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145202
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory