About   Help   FAQ
Raph1 Gene Detail
Summary
  • Symbol
    Raph1
  • Name
    Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
  • Synonyms
    9430025M21Rik, C730009O10Rik, lamellipodin, Lpd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924550
    NCBI Gene: 77300
  • Gene Overview
    MyGene.info: RAPH1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:60482292-60567104 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      84813 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 30.48 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RAPH1, Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAPH1, Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS2CR18, ALS2CR9, LPD, PREL2, PREL-2, RalGDS/AF-6, RMO1
  • Links
    NCBI Gene ID: 65059
    neXtProt AC: NX_Q70E73
    UniProt: Q70E73

  • Chr Location
    2q33.2; chr2:203433682-203535335 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 5 genetic backgrounds
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in all cells exhibit background sensitive neonatal or postnatal lethality, decreased body size, belly spotting and decreased melanocyte numbers in the trunk.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002211 VEGA Gene Model | MGI Sequence Detail 84813 C57BL/6J ±  kb
    transcript OTTMUST00000004475 VEGA | MGI Sequence Detail 10024 Not Applicable  
    polypeptide OTTMUSP00000002151 VEGA | MGI Sequence Detail 1266 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      315 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR000159 Ras-associating (RA) domain
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:3028042
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:249579 Bodo C, et al., Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice. Sci Rep. 2017 Jul 14;7(1):5365

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory