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Rspo4 Gene Detail
Summary
  • Symbol
    Rspo4
  • Name
    R-spondin 4
  • Synonyms
    A930029K19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924467
    NCBI Gene: 228770
Location & Maps
more
  • Sequence Map
    Chr2:151842927-151874668 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31742 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RSPO4, R-spondin 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RSPO4, R-spondin 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf182, CRISTIN4
  • Links
    NCBI Gene ID: 343637
    neXtProt AC: NX_Q2I0M5

  • Chr Location
    20p13; chr20:958452-1002284 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RSPO4 associations

Human Disease Mouse Models
       Nail Disorder, Nonsyndromic Congenital, 4; NDNC4   OMIM: 206800
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Rspo4
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015809 VEGA Gene Model | MGI Sequence Detail 31742 C57BL/6J ±  kb
transcript OTTMUST00000037592 VEGA | MGI Sequence Detail 2371 Not Applicable  
polypeptide OTTMUSP00000016847 VEGA | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    296 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014333 R-spondin-4
  • InterPro Domains
    IPR006212 Furin-like repeat
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR000884 Thrombospondin type-1 (TSP1) repeat
Molecular
Reagents
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  • All nucleic 14
    cDNA 11
    Primer pair 2
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 15
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory