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Rspo4 Gene Detail
Summary
  • Symbol
    Rspo4
  • Name
    R-spondin 4
  • Synonyms
    A930029K19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924467
    NCBI Gene: 228770
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:151842927-151874668 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    296 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924467
protein coding gene Chr2:151842579-151874668 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026646
protein coding gene Chr2:156349550-156382834 (+)
A/J MGP_AJ_G0026612
protein coding gene Chr2:150124387-150157289 (+)
AKR/J MGP_AKRJ_G0026582
protein coding gene Chr2:154496823-154530547 (+)
BALB/cJ MGP_BALBcJ_G0026621
protein coding gene Chr2:150436284-150468144 (+)
C3H/HeJ MGP_C3HHeJ_G0026364
protein coding gene Chr2:154888927-154920719 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027070
protein coding gene Chr2:160916067-160949380 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024441
protein coding gene Chr2:143742519-143774936 (+)
CAST/EiJ MGP_CASTEiJ_G0025825
protein coding gene Chr2:155120450-155152275 (+)
CBA/J MGP_CBAJ_G0026342
protein coding gene Chr2:166785614-166819607 (+)
DBA/2J MGP_DBA2J_G0026478
protein coding gene Chr2:149348779-149380520 (+)
FVB/NJ MGP_FVBNJ_G0026443
protein coding gene Chr2:147786341-147818586 (+)
LP/J MGP_LPJ_G0026582
protein coding gene Chr2:156518054-156551245 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026465
protein coding gene Chr2:170956462-170989006 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027125
protein coding gene Chr2:154381375-154414566 (+)
PWK/PhJ MGP_PWKPhJ_G0025559
protein coding gene Chr2:148870601-148903183 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025362
protein coding gene Chr2:153214849-153250484 (+)
WSB/EiJ MGP_WSBEiJ_G0025895
protein coding gene Chr2:155309238-155341765 (+)



Homology
more
  • Human Ortholog
    RSPO4, R-spondin 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RSPO4, R-spondin 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf182, CRISTIN4
  • Links
    NCBI Gene ID: 343637
    neXtProt AC: NX_Q2I0M5
    UniProt: Q2I0M5

  • Chr Location
    20p13; chr20:958452-1002264 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Rspo4
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032852 Ensembl Gene Model | MGI Sequence Detail 31742 C57BL/6J ±  kb
transcript ENSMUST00000042217 Ensembl | MGI Sequence Detail 2371 Not Applicable  
polypeptide ENSMUSP00000041578 Ensembl | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 14
    Primer pair 3
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 43
    Developmental Gene Expression 19
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:253067 Sigal M, et al., Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory