Wipf2 Gene Detail

Summary

• Symbol
  Wipf2
• Name
  WAS/WASL interacting protein family, member 2
• Synonyms
  1110014J05Rik, 5730509C05Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1924462
  NCBI Gene: 68524
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr11:98754464-98795866 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 62.71 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  1178 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924462	protein coding gene	Chr11:98754424-98796404 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019076	protein coding gene	Chr11:101482134-101529088 (+)
A/J	MGP_AJ_G0019044	protein coding gene	Chr11:97220554-97263953 (+)
AKR/J	MGP_AKRJ_G0019014	protein coding gene	Chr11:100232431-100279211 (+)
BALB/cJ	MGP_BALBcJ_G0019018	protein coding gene	Chr11:97717391-97758808 (+)
C3H/HeJ	MGP_C3HHeJ_G0018831	protein coding gene	Chr11:100380208-100423228 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019469	protein coding gene	Chr11:104580908-104632972 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017101	protein coding gene	Chr11:94779761-94822609 (+)
CAST/EiJ	MGP_CASTEiJ_G0018385	protein coding gene	Chr11:101365119-101408334 (+)
CBA/J	MGP_CBAJ_G0018802	protein coding gene	Chr11:108950099-109002443 (+)
DBA/2J	MGP_DBA2J_G0018910	protein coding gene	Chr11:96783792-96824899 (+)
FVB/NJ	MGP_FVBNJ_G0018899	protein coding gene	Chr11:96296708-96338508 (+)
LP/J	MGP_LPJ_G0018980	protein coding gene	Chr11:101935472-101982358 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018926	protein coding gene	Chr11:108639475-108684223 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019509	protein coding gene	Chr11:100589791-100634505 (+)
PWK/PhJ	MGP_PWKPhJ_G0018156	protein coding gene	Chr11:97824619-97869555 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017945	protein coding gene	Chr11:100327852-100379037 (+)
WSB/EiJ	MGP_WSBEiJ_G0018434	protein coding gene	Chr11:100547294-100593163 (+)

Homology

• Human Ortholog
  WIPF2, WAS/WASL interacting protein family member 2

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  WIPF2, WAS/WASL interacting protein family member 2
  
• Synonyms
  WICH, WIRE
• Links
  HGNC:30923

  NCBI Gene ID: 147179

  UniProt: Q8TF74

  
  
• Chr Location
  17q21.2; chr17:40219304-40284136 (+)  GRCh38

---

• MGI Vertebrate Homology
  Wipf2 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: WIPF2
• Gene Tree
  Wipf2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotype references
  

• All Mutations and Alleles
  24
• Gene trapped
  20
• Targeted
  4
• Genomic Mutations
  1 involving Wipf2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  38 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  12

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase wipf2

Sequences &
Gene Models

• All Sequences
  42
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS25366.1

• Ensembl
  ENSMUSG00000038013 (Evidence)
• NCBI Gene
  68524

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000038013	Ensembl Gene Model | MGI Sequence Detail	41403	C57BL/6J
transcript	ENSMUST00000037480	Ensembl | MGI Sequence Detail	7011	Not Applicable
polypeptide	ENSMUSP00000046991	Ensembl | MGI Sequence Detail	440	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000017423 WAS/WASL-interacting protein family member 2
  (term hierarchy)
• InterPro Domains
  IPR003124 WH2 domain
• GlyGen
  Q6PEV3 5 sites, 1 O-linked glycan (2 sites)

Molecular
Reagents

• All nucleic 12

  cDNA 12

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1915774, MGI:2143971, MGI:2686022

References

• Summaries
  All 33

  Phenotypes 12
• Earliest
  J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
• Latest
  J:190527 Garber JJ, et al., Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun. 2012 Dec;80(12):4071-7

TSS for Wipf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104807	Chr11:98754436-98754472 (+)	-10 bp
Tssr104808	Chr11:98754481-98754516 (+)	35 bp
Tssr104809	Chr11:98754581-98754611 (+)	132 bp
Tssr104810	Chr11:98782009-98782027 (+)	27,554 bp
Tssr104811	Chr11:98794027-98794040 (+)	39,570 bp