Wipf2 MGI Mouse Gene Detail - MGI:1924462 - WAS/WASL interacting protein family, member 2

Symbol

Wipf2
Name

WAS/WASL interacting protein family, member 2
Synonyms

1110014J05Rik, 5730509C05Rik

Feature Type

protein coding gene
IDs

MGI:1924462
NCBI Gene: 68524
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:98754464-98795866 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 62.71 cM
Mapping Data

3 experiments

SNPs within 2kb

1178 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924462	protein coding gene	Chr11:98754424-98796404 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019076	protein coding gene	Chr11:101482134-101529088 (+)
A/J	MGP_AJ_G0019044	protein coding gene	Chr11:97220554-97263953 (+)
AKR/J	MGP_AKRJ_G0019014	protein coding gene	Chr11:100232431-100279211 (+)
BALB/cJ	MGP_BALBcJ_G0019018	protein coding gene	Chr11:97717391-97758808 (+)
C3H/HeJ	MGP_C3HHeJ_G0018831	protein coding gene	Chr11:100380208-100423228 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019469	protein coding gene	Chr11:104580908-104632972 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017101	protein coding gene	Chr11:94779761-94822609 (+)
CAST/EiJ	MGP_CASTEiJ_G0018385	protein coding gene	Chr11:101365119-101408334 (+)
CBA/J	MGP_CBAJ_G0018802	protein coding gene	Chr11:108950099-109002443 (+)
DBA/2J	MGP_DBA2J_G0018910	protein coding gene	Chr11:96783792-96824899 (+)
FVB/NJ	MGP_FVBNJ_G0018899	protein coding gene	Chr11:96296708-96338508 (+)
LP/J	MGP_LPJ_G0018980	protein coding gene	Chr11:101935472-101982358 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018926	protein coding gene	Chr11:108639475-108684223 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019509	protein coding gene	Chr11:100589791-100634505 (+)
PWK/PhJ	MGP_PWKPhJ_G0018156	protein coding gene	Chr11:97824619-97869555 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017945	protein coding gene	Chr11:100327852-100379037 (+)
WSB/EiJ	MGP_WSBEiJ_G0018434	protein coding gene	Chr11:100547294-100593163 (+)

Human Ortholog

WIPF2, WAS/WASL interacting protein family member 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WIPF2, WAS/WASL interacting protein family member 2
Synonyms

WICH, WIRE
Links

HGNC:30923

NCBI Gene ID: 147179

UniProt: Q8TF74
Chr Location

17q21.2; chr17:40219304-40284136 (+) GRCh38

MGI Vertebrate Homology

Wipf2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: WIPF2
Gene Tree

Wipf2

less

Phenotype Summary

12 phenotype references

All Mutations and Alleles

24
Gene trapped

20
Targeted

4
Genomic Mutations

1 involving Wipf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available

less

All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wipf2

less

All Sequences

42
RefSeq

2
UniProt

2
CCDS

CCDS25366.1

Ensembl

ENSMUSG00000038013 (Evidence)
NCBI Gene

68524

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038013	Ensembl Gene Model \| MGI Sequence Detail	41403	C57BL/6J	± kb
transcript	ENSMUST00000037480	Ensembl \| MGI Sequence Detail	7011	Not Applicable
polypeptide	ENSMUSP00000046991	Ensembl \| MGI Sequence Detail	440	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000017423 WAS/WASL-interacting protein family member 2

(term hierarchy)
InterPro Domains

IPR003124 WH2 domain
GlyGen

Q6PEV3 5 sites, 1 O-linked glycan (2 sites)

less

All nucleic 12

cDNA 12

Microarray probesets 3

less

MGI:1915774, MGI:2143971, MGI:2686022

Summaries

All 36

Gene Ontology 3

Phenotypes 12
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:190527 Garber JJ, et al., Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun. 2012 Dec;80(12):4071-7

TSS for Wipf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104807	Chr11:98754436-98754472 (+)	-10 bp
Tssr104808	Chr11:98754481-98754516 (+)	35 bp
Tssr104809	Chr11:98754581-98754611 (+)	132 bp
Tssr104810	Chr11:98782009-98782027 (+)	27,554 bp
Tssr104811	Chr11:98794027-98794040 (+)	39,570 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24