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Sobp Gene Detail
Summary
  • Symbol
    Sobp
  • Name
    sine oculis binding protein
  • Synonyms
    2900009C16Rik, 5330439J01Rik, jc, Jxc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924427
    NCBI Gene: 109205
  • Gene Overview
    MyGene.info: SOBP
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:43002500-43174530 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 22.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    640 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924427
protein coding gene Chr10:43002488-43174905 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017190
protein coding gene Chr10:41741060-41921984 (-)
A/J MGP_AJ_G0017167
protein coding gene Chr10:40577724-40751221 (-)
AKR/J MGP_AKRJ_G0017127
protein coding gene Chr10:41183983-41364817 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0016950
protein coding gene Chr10:41549145-41729420 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017588
protein coding gene Chr10:43015059-43201885 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015284
protein coding gene Chr10:38417338-38594701 (-)
CAST/EiJ MGP_CASTEiJ_G0016529
protein coding gene Chr10:41753035-41941385 (-)
CBA/J MGP_CBAJ_G0016924
protein coding gene Chr10:45000488-45189659 (-)
DBA/2J MGP_DBA2J_G0017029
protein coding gene Chr10:40055902-40230088 (-)
FVB/NJ MGP_FVBNJ_G0017024
protein coding gene Chr10:39546726-39723532 (-)
LP/J MGP_LPJ_G0017106
protein coding gene Chr10:41747494-41934669 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017054
protein coding gene Chr10:45720311-45904338 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017625
protein coding gene Chr10:41184272-41373209 (-)
PWK/PhJ MGP_PWKPhJ_G0016309
protein coding gene Chr10:39933344-40114587 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016093
protein coding gene Chr10:41021348-41206189 (-)
WSB/EiJ MGP_WSBEiJ_G0016592
protein coding gene Chr10:41480048-41666777 (-)



Homology
more
  • Human Ortholog
    SOBP, sine oculis binding protein homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOBP, sine oculis binding protein homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JXC1, MRAMS
  • Links
    NCBI Gene ID: 55084
    neXtProt AC: NX_A7XYQ1
    UniProt: A7XYQ1

  • Chr Location
    6q21; chr6:107490104-107661309 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41216
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SOBP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit open-field hyperactivity and circling behavior from weaning. Their hearing thresholds are elevated at all frequencies; the hearing impairment does not progress over time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038248 Ensembl Gene Model | MGI Sequence Detail 172031 C57BL/6J ±  kb
    transcript ENSMUST00000040275 Ensembl | MGI Sequence Detail 4980 Not Applicable  
    polypeptide ENSMUSP00000040072 Ensembl | MGI Sequence Detail 864 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015391 sine oculis-binding protein
    • InterPro Domains
      IPR026092 Retinoic acid-induced protein 2/sine oculis-binding protein homologue
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 29

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-11519, MGI:1925650, MGI:96631
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:197117 Sun H, et al., Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. J Biol Chem. 2012 Dec 7;287(50):42071-83

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory