About   Help   FAQ
Sobp Gene Detail
Summary
  • Symbol
    Sobp
  • Name
    sine oculis-binding protein homolog (Drosophila)
  • Synonyms
    2900009C16Rik, 5330439J01Rik, jc, Jxc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924427
    NCBI Gene: 109205
  • Gene Overview
    MyGene.info: SOBP
Location & Maps
more
  • Sequence Map
    Chr10:43002500-43174530 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      172031 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 22.89 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SOBP, sine oculis binding protein homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOBP, sine oculis binding protein homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JXC1, MRAMS
  • Links
    NCBI Gene ID: 55084
    neXtProt AC: NX_A7XYQ1

  • Chr Location
    6q21; chr6:107490098-107661309 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41216
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SOBP
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SOBP associations

Human Disease Mouse Models
       Mental Retardation, Anterior Maxillary Protrusion, and Strabismus;   OMIM: 613671
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    2
  • Targeted
    2
  • Genomic Mutations
    2 involving Sobp
  • Incidental Mutations
Homozygous mutant mice exhibit open-field hyperactivity and circling behavior from weaning. Their hearing thresholds are elevated at all frequencies; the hearing impairment does not progress over time.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046585 VEGA Gene Model | MGI Sequence Detail 172031 C57BL/6J ±  kb
transcript OTTMUST00000121122 VEGA | MGI Sequence Detail 4980 Not Applicable  
polypeptide OTTMUSP00000066852 VEGA | MGI Sequence Detail 864 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    640 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015391 sine oculis-binding protein
  • InterPro Domains
    IPR026092 Retinoic acid-induced protein 2/sine oculis-binding protein homologue
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-11519, MGI:1925650, MGI:96631
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:13506 Southard JL, Jackson circler, jc. Mouse News Lett. 1970;42:30
  • Latest
    J:197117 Sun H, et al., Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. J Biol Chem. 2012 Dec 7;287(50):42071-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory