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Atp6v0d2
Gene Detail
Symbol

Name
ID
Atp6v0d2
ATPase, H+ transporting, lysosomal V0 subunit D2
MGI:1924415
Synonyms
1620401A02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
7.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:19876841-19922605 bp, - strand
From VEGA annotation of GRCm38

  45765 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:72090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ATP6V0D2
Protein SuperFamily: V-type ATPase, subunit d
Gene Tree: Atp6v0d2

Human
homologs
ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 245972
neXtProt AC: NX_Q8N8Y2

Human Synonyms: ATP6D2, VMA6

Human Chr (Location): 8q21.13; chr8:86098910-86154225 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display osteopetrosis and impaired osteoclast maturation.
 
Interactions
Atp6v0d2 interacts with 234 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process ATP hydrolysis coupled proton transport, ion transport, ...
Component apical plasma membrane, early endosome, ...
Function hydrogen ion transmembrane transporter activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (108)    Tissues (107)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 12
RT-PCR 2
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atp6v0d2    NEW 
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006382 (Evidence)
Ensembl Gene Model ENSMUSG00000028238 (Evidence)
Entrez Gene 242341 (Evidence)
UniGene 19298
DFCI TC1578136
DoTS DT.97354339
NIA Mouse Gene Index U024874
Consensus CDS Project CCDS17994.1
International Mouse Phenotyping Consortium Status Atp6v0d2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006382 VEGA Gene Model | MGI Sequence Detail 45765 C57BL/6J ±  kb
transcript OTTMUST00000014512 VEGA | MGI Sequence Detail 2539 Not Applicable 
polypeptide OTTMUSP00000006743 VEGA | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(308 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002843 ATPase, V0 complex, c/d subunit
InterPro IPR016727 ATPase, V0 complex, subunit d
Protein Ontology PR:000004477 V-type proton ATPase subunit d 2
References
(Earliest) J:115141 Hackam DJ, et al., Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. J Exp Med. 1998 Jul 20;188(2):351-64
(Latest) J:198051 Kim H, et al., Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab. 2013 Feb 5;17(2):249-60
All references(36)
Other
accession IDs
MGI:2140238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory