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Ankrd11 Gene Detail
Summary
  • Symbol
    Ankrd11
  • Name
    ankyrin repeat domain 11
  • Synonyms
    2410104C19Rik, 3010027A04Rik, 9530048I21Rik, Yod
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924337
    NCBI Gene: 77087
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:122883822-123042277 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      158456 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 72.00 cM, cytoband E2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ANKRD11, ankyrin repeat domain 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ANKRD11, ankyrin repeat domain 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ANCO1, ANCO-1, LZ16, T13
  • Links
    NCBI Gene ID: 29123
    neXtProt AC: NX_Q6UB99
    UniProt: Q6UB99

  • Chr Location
    16q24.3; chr16:89267619-89490561 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ANKRD11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele die by E9.5, are small and fail to turn. Mice heterozygous for a spontaneous allele exhibit craniofacial abnormalities, decreased weight, osteoporosis and osteopenia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037981 VEGA Gene Model | MGI Sequence Detail 158456 C57BL/6J ±  kb
    transcript OTTMUST00000150996 VEGA | MGI Sequence Detail 8455 Not Applicable  
    polypeptide OTTMUSP00000078308 VEGA | MGI Sequence Detail 2643 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      637 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR020683 Ankyrin repeat-containing domain
      IPR036770 Ankyrin repeat-containing domain superfamily
    Molecular
    Reagents
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    • All nucleic 273
      cDNA 272
      Primer pair 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1890436, MGI:1924033, MGI:1925914, MGI:2142446, MGI:2685022
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:255082 Kurogi S, et al., Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Sci Rep. 2017 Jan 20;7:40692

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory