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Ankrd11
Gene Detail
Symbol

Name
ID
Ankrd11
ankyrin repeat domain 11
MGI:1924337
Synonyms
2410104C19Rik, 3010027A04Rik, 9530048I21Rik, Yod
Feature Type
protein coding gene
Genetic Map
Chromosome 8
72.00 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:122883337-122974793 bp, - strand
From VEGA annotation of GRCm38

  91457 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ANKRD11
Gene Tree: Ankrd11

Human
homologs
ANKRD11, ankyrin repeat domain 11
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 29123
neXtProt AC: NX_Q6UB99

Human Synonyms: ANCO1, ANCO-1, LZ16, T13

Human Chr (Location): 16q24.3; chr16:89267619-89490574 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ANKRD11

Mutations,
alleles, and
phenotypes
All mutations/alleles(109) : Chemically induced (ENU)(1) Gene trapped(105) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a spontaneous allele die by E9.5, are small and fail to turn. Mice heterozygous for a spontaneous allele exhibit craniofacial abnormalities, decreased weight, osteoporosis and osteopenia.
 
Interactions
Ankrd11 interacts with 473 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process bone development, face morphogenesis, ...
Component cytoplasm, nucleoplasm, ...
Function molecular_function
External Resources: FuncBase
Expression
cDNA source data(271)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ankrd11    NEW 
Molecular
reagents
All nucleic(271) cDNA(271)
Microarray probesets(12)
Other database
links
VEGA Gene Model OTTMUSG00000037981 (Evidence)
Ensembl Gene Model ENSMUSG00000035569 (Evidence)
Entrez Gene 77087 (Evidence)
UniGene 31567
DFCI TC1627143, TC1605415, TC1604327, TC1585940, TC1581502, TC1639702, TC1668029, TC1658663
DoTS DT.101737940, DT.101404084, DT.487775, DT.102551862, DT.487155, DT.40148363, DT.102557425, DT.94284055, DT.55208687, DT.528686
NIA Mouse Gene Index U030366, U059059
Consensus CDS Project CCDS40507.2
International Mouse Phenotyping Consortium Status Ankrd11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037981 VEGA Gene Model | MGI Sequence Detail 91457 C57BL/6J ±  kb
transcript OTTMUST00000097880 VEGA | MGI Sequence Detail 8869 Not Applicable 
polypeptide OTTMUSP00000054895 VEGA | MGI Sequence Detail 2643 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(4) UniProt(13)
Polymorphisms
SNPs within 2kb(640 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000004041 ankyrin repeat domain-containing protein 11
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:186795 Sirmaci A, et al., Mutations in ANKRD11 cause KBG syndrome, characterized by intellectual disability, skeletal malformations, and macrodontia. Am J Hum Genet. 2011 Aug 12;89(2):289-94
All references(46)
Other
accession IDs
MGI:1890436, MGI:1924033, MGI:1925914, MGI:2142446, MGI:2685022

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory