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Ankrd11 Gene Detail
Summary
  • Symbol
    Ankrd11
  • Name
    ankyrin repeat domain 11
  • Synonyms
    2410104C19Rik, 3010027A04Rik, 9530048I21Rik, Yod
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924337
    NCBI Gene: 77087
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:122883822-123042277 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 72.00 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    637 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924337
protein coding gene Chr8:122883822-123042284 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034239
protein coding gene Chr8:126453608-126551682 (-)
A/J MGP_AJ_G0034219
protein coding gene Chr8:121223097-121317700 (-)
AKR/J MGP_AKRJ_G0034146
protein coding gene Chr8:124761515-124855045 (-)
BALB/cJ MGP_BALBcJ_G0034213
protein coding gene Chr8:121416085-121509348 (-)
C3H/HeJ MGP_C3HHeJ_G0033923
protein coding gene Chr8:125452779-125547602 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034732
protein coding gene Chr8:130691849-130789904 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031674
protein coding gene Chr8:114042783-114132280 (-)
CAST/EiJ MGP_CASTEiJ_G0033251
protein coding gene Chr8:125537221-125631977 (-)
CBA/J MGP_CBAJ_G0033896
protein coding gene Chr8:135484845-135580958 (-)
DBA/2J MGP_DBA2J_G0034053
protein coding gene Chr8:120405462-120497643 (-)
FVB/NJ MGP_FVBNJ_G0033996
protein coding gene Chr8:119556397-119647939 (-)
LP/J MGP_LPJ_G0034142
protein coding gene Chr8:126580985-126681958 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034043
protein coding gene Chr8:137623504-137716138 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034751
protein coding gene Chr8:124932548-125028263 (-)
PWK/PhJ MGP_PWKPhJ_G0032952
protein coding gene Chr8:120228642-120323604 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032792
protein coding gene Chr8:123655656-123750270 (-)
WSB/EiJ MGP_WSBEiJ_G0033367
protein coding gene Chr8:125690919-125783671 (-)



Homology
more
  • Human Ortholog
    ANKRD11, ankyrin repeat domain 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ANKRD11, ankyrin repeat domain 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANCO1, ANCO-1, LZ16, T13
  • Links
    NCBI Gene ID: 29123
    neXtProt AC: NX_Q6UB99
    UniProt: Q6UB99

  • Chr Location
    16q24.3; chr16:89267619-89490561 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ANKRD11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele die by E9.5, are small and fail to turn. Mice heterozygous for a spontaneous allele exhibit craniofacial abnormalities, decreased weight, osteoporosis and osteopenia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035569 Ensembl Gene Model | MGI Sequence Detail 158456 C57BL/6J ±  kb
    transcript ENSMUST00000098333 Ensembl | MGI Sequence Detail 7995 Not Applicable  
    polypeptide ENSMUSP00000095938 Ensembl | MGI Sequence Detail 2664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR020683 Ankyrin repeat-containing domain
      IPR036770 Ankyrin repeat-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 273
      cDNA 272
      Primer pair 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1890436, MGI:1924033, MGI:1925914, MGI:2142446, MGI:2685022
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:255082 Kurogi S, et al., Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Sci Rep. 2017 Jan 20;7:40692

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory