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Cacfd1 Gene Detail
Summary
  • Symbol
    Cacfd1
  • Name
    calcium channel flower domain containing 1
  • Synonyms
    5930434B04Rik, mFwe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924317
    NCBI Gene: 381356
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:26899938-26911101 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.17 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924317
 protein coding gene Chr2:26899867-26911102 (+)
129S1/SvImJ ENSMUSG00200048299
 protein coding gene Chr2:23859212-23870606 (+)
A/J ENSMUSG00195048365
 protein coding gene Chr2:23961610-23973006 (+)
AKR/J ENSMUSG00220048712
 protein coding gene Chr2:24079404-24090800 (+)
BALB/cJ ENSMUSG00180051006
 protein coding gene Chr2:23980657-23992053 (+)
C3H/HeJ ENSMUSG00175049886
 protein coding gene Chr2:23950030-23961424 (+)
C57BL/6NJ ENSMUSG00215044545
 protein coding gene Chr2:24008791-24020185 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023334
 protein coding gene Chr2:22869400-22880530 (+)
CAST/EiJ ENSTCUG00005051538
 protein coding gene Chr2:23697997-23709488 (+)
CBA/J ENSMUSG00210017431
 protein coding gene Chr2:23983676-23995072 (+)
DBA/2J ENSMUSG00185050276
 protein coding gene Chr2:23875695-23887091 (+)
FVB/NJ ENSMUSG00205046554
 protein coding gene Chr2:23728366-23739822 (+)
JF1/MsJ ENSUMUG00000051082
 protein coding gene Chr2:23776428-23787870 (+)
LP/J ENSMUSG00230045200
 protein coding gene Chr2:25795145-25806539 (+)
NOD/ShiLtJ ENSMUSG00190033881
 protein coding gene Chr2:23967998-23979381 (+)
NZO/HlLtJ ENSMUSG00225007557
 protein coding gene Chr2:33552718-33564114 (+)
PWK/PhJ ENSLUMG00010052384
 protein coding gene Chr2:23855227-23866658 (+)
SPRET/EiJ ENSMSPG00010044742
 protein coding gene Chr2:24580355-24591954 (+)
WSB/EiJ ENSIUOG00005050982
 protein coding gene Chr2:23833195-23844589 (+)



Homology
more
  • Human Ortholog
    CACFD1, calcium channel flower domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CACFD1, calcium channel flower domain containing 1
  • Synonyms
    C9orf7, D9S2135, FLOWER
  • Links
    NCBI Gene ID: 11094
    UniProt: Q9UGQ2

  • Chr Location
    9q34.2; chr9:133459965-133470848 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance to DMPA/TPA-induced papilloma formation (number and latency) associated with decreased cell proliferation and increased apoptosis of cells in papillomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    613
  • Tissues
    2
  • cDNA Data
    48
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015488 Ensembl Gene Model | MGI Sequence Detail 11164 C57BL/6J ±  kb
    transcript ENSMUST00000114006 Ensembl | MGI Sequence Detail 1648 Not Applicable  
    polypeptide ENSMUSP00000109639 Ensembl | MGI Sequence Detail 171 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 48
      Primer pair 4

      Microarray probesets 7
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:363714 Ravichandran K, et al., Required minimal protein domain of flower for synaptobrevin2 endocytosis in cytotoxic T cells. Cell Mol Life Sci. 2024 Dec 18;82(1):8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory