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Ston1 Gene Detail
Summary
  • Symbol
    Ston1
  • Name
    stonin 1
  • Synonyms
    4921524J06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924307
    NCBI Gene: 77057
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:88597635-88645724 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 58.10 cM, cytoband E5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    379 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924307
protein coding gene Chr17:88597635-88662586 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024111
protein coding gene Chr17:92095421-92156055 (+)
A/J MGP_AJ_G0024071
protein coding gene Chr17:89122626-89186323 (+)
AKR/J MGP_AKRJ_G0024040
protein coding gene Chr17:90612411-90674852 (+)
BALB/cJ MGP_BALBcJ_G0024072
protein coding gene Chr17:88947705-89010471 (+)
C3H/HeJ MGP_C3HHeJ_G0023837
protein coding gene Chr17:91508711-91568780 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024517
protein coding gene Chr17:95299776-95372086 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021955
protein coding gene Chr17:84180530-84245942 (+)
CAST/EiJ MGP_CASTEiJ_G0023316
protein coding gene Chr17:92377525-92441963 (+)
CBA/J MGP_CBAJ_G0023810
protein coding gene Chr17:99320340-99387136 (+)
DBA/2J MGP_DBA2J_G0023939
protein coding gene Chr17:87508378-87570131 (+)
FVB/NJ MGP_FVBNJ_G0023905
protein coding gene Chr17:87040170-87105163 (+)
LP/J MGP_LPJ_G0024023
protein coding gene Chr17:92889965-92955914 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023933
protein coding gene Chr17:99108488-99170136 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024562
protein coding gene Chr17:91159538-91231450 (+)
PWK/PhJ MGP_PWKPhJ_G0023061
protein coding gene Chr17:87205684-87264804 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022872
protein coding gene Chr17:87896985-87963352 (+)
WSB/EiJ MGP_WSBEiJ_G0023382
protein coding gene Chr17:92019442-92084063 (+)



Homology
more
  • Human Ortholog
    STON1, stonin 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    STON1, stonin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SALF, SBLF, STN1, STNB1
  • Links
    NCBI Gene ID: 11037
    neXtProt AC: NX_Q9Y6Q2
    UniProt: Q9Y6Q2

  • Chr Location
    2p16.3; chr2:48530169-48598515 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are overtly normal. Mouse embryonic fibroblasts derived from homozygous null mice display alterations in focal adhesion dynamics and an increase in cellular signaling and directional cell migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 77057 NCBI Gene Model | MGI Sequence Detail 48090 C57BL/6J ±  kb
transcript NM_029858 RefSeq | MGI Sequence Detail 2983 C57BL/6  
polypeptide Q8CDJ8 UniProt | EBI | MGI Sequence Detail 730 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147145
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:227201 Feutlinske F, et al., Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility. Nat Commun. 2015;6:8535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory