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Krt76
Gene Detail
Symbol

Name
ID
Krt76
keratin 76
MGI:1924305
Synonyms
2310001L23Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:101884351-101892920 bp, - strand
From VEGA annotation of GRCm38

  8570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22931  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: KRT76
Gene Tree: Krt76

Human
homologs
KRT76, keratin 76, type II
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51350
neXtProt AC: NX_Q01546

Human Synonyms: HUMCYT2A, KRT2B, KRT2P

Human Chr (Location): 12q13.13; chr12:52768155-52777345 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Krt76 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes mutants exhibit abnormalities in the hair cycle, tail skin and pigmentation, in the epidermis, and in the sebaceous gland.
 
Phenotype Images(2)
Interactions
Krt76 interacts with 79 markers (Mir18b, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process epidermis development, sebaceous gland development
Component extracellular exosome, intermediate filament, ...
Function structural molecule activity
External Resources: FuncBase
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000028008 (Evidence)
Ensembl Gene Model ENSMUSG00000075402 (Evidence)
Entrez Gene 77055 (Evidence)
UniGene 195788
DFCI TC1588620
DoTS DT.55183433
NIA Mouse Gene Index U377132
Consensus CDS Project CCDS27866.1
International Mouse Phenotyping Consortium Status Krt76
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028008 VEGA Gene Model | MGI Sequence Detail 8570 C57BL/6J ±  kb
transcript OTTMUST00000069364 VEGA | MGI Sequence Detail 2312 Not Applicable 
polypeptide OTTMUSP00000035214 VEGA | MGI Sequence Detail 594 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Keratin, type II
Protein Ontology PR:000009491 keratin, type II cytoskeletal 2 oral
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory