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Krt76 Gene Detail
Summary
  • Symbol
    Krt76
  • Name
    keratin 76
  • Synonyms
    2310001L23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924305
    NCBI Gene: 77055
Location & Maps
more
  • Sequence Map
    Chr15:101884351-101892920 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8570 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.10 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KRT76, keratin 76
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KRT76, keratin 76
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HUMCYT2A, KRT2B, KRT2P
  • Links
    NCBI Gene ID: 51350
    neXtProt AC: NX_Q01546

  • Chr Location
    12q13.13; chr12:52768155-52777345 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    4 involving Krt76
  • Incidental Mutations
Homozygotes mutants exhibit abnormalities in the hair cycle, tail skin and pigmentation, in the epidermis, and in the sebaceous gland.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028008 VEGA Gene Model | MGI Sequence Detail 8570 C57BL/6J ±  kb
transcript OTTMUST00000069364 VEGA | MGI Sequence Detail 2312 Not Applicable  
polypeptide OTTMUSP00000035214 VEGA | MGI Sequence Detail 594 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    93 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009491 keratin, type II cytoskeletal 2 oral
  • InterPro Domains
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR003054 Keratin, type II
    IPR032444 Keratin type II head
Molecular
Reagents
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  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 29
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:232539 DiTommaso T, et al., Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. PLoS Genet. 2014 Oct;10(10):e1004705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory