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Sun1 Gene Detail
Summary
  • Symbol
    Sun1
  • Name
    Sad1 and UNC84 domain containing 1
  • Synonyms
    4632417G13Rik, 5730434D03Rik, mKIAA0810, Unc84a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924303
    NCBI Gene: 77053
  • Gene Overview
    MyGene.info: SUN1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139200637-139249840 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 78.12 cM, cytoband G1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924303
protein coding gene Chr5:139200556-139249840 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030277
protein coding gene Chr5:144154507-144206696 (+)
A/J MGP_AJ_G0030246
protein coding gene Chr5:138053655-138101975 (+)
AKR/J MGP_AKRJ_G0030178
protein coding gene Chr5:142357558-142406123 (+)
BALB/cJ MGP_BALBcJ_G0030263
protein coding gene Chr5:139299990-139349825 (+)
C3H/HeJ MGP_C3HHeJ_G0029974
protein coding gene Chr5:143127355-143179556 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030708
protein coding gene Chr5:149472783-149526800 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027926
protein coding gene Chr5:131915397-131962707 (+)
CAST/EiJ MGP_CASTEiJ_G0029379
protein coding gene Chr5:142539274-142588927 (+)
CBA/J MGP_CBAJ_G0029944
protein coding gene Chr5:155642686-155694053 (+)
DBA/2J MGP_DBA2J_G0030094
protein coding gene Chr5:137869494-137916565 (+)
FVB/NJ MGP_FVBNJ_G0030049
protein coding gene Chr5:136967251-137016978 (+)
LP/J MGP_LPJ_G0030180
protein coding gene Chr5:144777979-144828141 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030080
protein coding gene Chr5:158326177-158379978 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030748
protein coding gene Chr5:142164615-142215186 (+)
PWK/PhJ MGP_PWKPhJ_G0029094
protein coding gene Chr5:136863244-136910734 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028930
protein coding gene Chr5:139852002-139899917 (+)
WSB/EiJ MGP_WSBEiJ_G0029453
protein coding gene Chr5:142928798-142979885 (+)



Homology
more
  • Human Ortholog
    SUN1, Sad1 and UNC84 domain containing 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SUN1, Sad1 and UNC84 domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    UNC84A
  • Links
    NCBI Gene ID: 23353
    neXtProt AC: NX_O94901
    UniProt: O94901

  • Chr Location
    7p22.3; chr7:815557-874920 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 7 genetic backgrounds
    24 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit sterility due to arrested meiosis, hearing loss associated with outer hair cell degeneration, abnormal cerebellum development, ataxia, impaired motor coordination, and abnormal Purkinje cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036817 Ensembl Gene Model | MGI Sequence Detail 49204 C57BL/6J ±  kb
    transcript ENSMUST00000058716 Ensembl | MGI Sequence Detail 4134 Not Applicable  
    polypeptide ENSMUSP00000056655 Ensembl | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 191
      cDNA 191

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922034
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 9
      Gene Ontology 17
      Phenotypes 38
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:263357 Chamessian A, et al., Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn. Sci Rep. 2018 May 1;8(1):6809

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory