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Arsk Gene Detail
Summary
  • Symbol
    Arsk
  • Name
    arylsulfatase K
  • Synonyms
    2810429K17Rik, 4833414G15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924291
    NCBI Gene: 77041
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:76208541-76246779 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.95 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    324 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924291
protein coding gene Chr13:76208541-76246794 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020777
protein coding gene Chr13:76607240-76642253 (-)
A/J MGP_AJ_G0020733
protein coding gene Chr13:73997530-74033628 (-)
AKR/J MGP_AKRJ_G0020706
protein coding gene Chr13:76243450-76277296 (-)
BALB/cJ MGP_BALBcJ_G0020729
protein coding gene Chr13:74478516-74518318 (-)
C3H/HeJ MGP_C3HHeJ_G0020523
protein coding gene Chr13:75947135-75985257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021166
protein coding gene Chr13:79184127-79217599 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018734
protein coding gene Chr13:70812076-70840894 (-)
CAST/EiJ MGP_CASTEiJ_G0020041
protein coding gene Chr13:75031204-75063431 (-)
CBA/J MGP_CBAJ_G0020482
protein coding gene Chr13:82188843-82225006 (-)
DBA/2J MGP_DBA2J_G0020607
protein coding gene Chr13:73707996-73739402 (-)
FVB/NJ MGP_FVBNJ_G0020587
protein coding gene Chr13:72765261-72799396 (-)
LP/J MGP_LPJ_G0020680
protein coding gene Chr13:76876153-76912491 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020616
protein coding gene Chr13:80579646-80622074 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021206
protein coding gene Chr13:75569422-75603475 (-)
PWK/PhJ MGP_PWKPhJ_G0019794
protein coding gene Chr13:72620619-72652919 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019617
protein coding gene Chr13:71943599-71969606 (-)
WSB/EiJ MGP_WSBEiJ_G0020098
protein coding gene Chr13:76071061-76099805 (-)



Homology
more
  • Human Ortholog
    ARSK, arylsulfatase family member K
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARSK, arylsulfatase family member K
  • Synonyms
    TSULF
  • Links
    NCBI Gene ID: 153642
    neXtProt AC: NX_Q6UWY0
    UniProt: Q6UWY0

  • Chr Location
    5q15; chr5:95555108-95605102 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Arsk mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show moderate accumulation of heparan sulfate and chondroitin sulfate metabolites and signs of impaired social behavior and spatial reference memory in the absence of prominent lysosomal storage pathology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021592 Ensembl Gene Model | MGI Sequence Detail 38239 C57BL/6J ±  kb
    transcript ENSMUST00000120573 Ensembl | MGI Sequence Detail 3657 Not Applicable  
    polypeptide ENSMUSP00000113274 Ensembl | MGI Sequence Detail 556 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 37
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1926165
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:302659 Trabszo C, et al., Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate. Biochem J. 2020 Sep 18;477(17):3433-3451

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/14/2021
    MGI 6.17
    The Jackson Laboratory