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Mrap Gene Detail
Summary
  • Symbol
    Mrap
  • Name
    melanocortin 2 receptor accessory protein
  • Synonyms
    1110025G12Rik, C21ORF61
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924287
    NCBI Gene: 77037
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:90738207-90749785 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 51.90 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924287
protein coding gene Chr16:90738207-90749785 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023028
protein coding gene Chr16:91702383-91716065 (+)
A/J MGP_AJ_G0022996
protein coding gene Chr16:87424788-87437150 (+)
AKR/J MGP_AKRJ_G0022966
protein coding gene Chr16:90058410-90069379 (+)
BALB/cJ MGP_BALBcJ_G0022998
protein coding gene Chr16:87946264-87958328 (+)
C3H/HeJ MGP_C3HHeJ_G0022759
protein coding gene Chr16:90621531-90637415 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023445
protein coding gene Chr16:94681150-94698115 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020947
protein coding gene Chr16:85125547-85137313 (+)
CAST/EiJ MGP_CASTEiJ_G0022278
protein coding gene Chr16:91169402-91186140 (+)
CBA/J MGP_CBAJ_G0022728
protein coding gene Chr16:98708276-98726164 (+)
DBA/2J MGP_DBA2J_G0022862
protein coding gene Chr16:87324136-87335725 (+)
FVB/NJ MGP_FVBNJ_G0022836
protein coding gene Chr16:86449680-86460917 (+)
LP/J MGP_LPJ_G0022932
protein coding gene Chr16:91390867-91405492 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022857
protein coding gene Chr16:103275713-103301374 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023463
protein coding gene Chr16:90568483-90579695 (+)
PWK/PhJ MGP_PWKPhJ_G0022023
protein coding gene Chr16:87493854-87505638 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021853
protein coding gene Chr16:90134168-90145647 (+)
WSB/EiJ MGP_WSBEiJ_G0022330
protein coding gene Chr16:90804369-90817511 (+)



Homology
more
  • Human Ortholog
    MRAP, melanocortin 2 receptor accessory protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MRAP, melanocortin 2 receptor accessory protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B27, C21orf61, FALP, FGD2, GCCD2
  • Links
    NCBI Gene ID: 56246
    neXtProt AC: NX_Q8TCY5
    UniProt: Q8TCY5

  • Chr Location
    21q22.11; chr21:32291813-32314784 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mrap mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality associated with failure of lungs to inflate, small adrenal glands, thickened adrenal casule due to hyperplasia and glucocorticoid deficiency symptoms.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77037 NCBI Gene Model | MGI Sequence Detail 11579 C57BL/6J ±  kb
    transcript NR_155757 RefSeq | MGI Sequence Detail 1267 C57BL/6  
    polypeptide Q9D159 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 5
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:292262 Thomas JR, et al., Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome. Bone. 2020 Jul;136:115367

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/10/2020
    MGI 6.16
    The Jackson Laboratory