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Slc9a8
Gene Detail
Symbol

Name
ID
Slc9a8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
MGI:1924281
Synonyms
1200006P13Rik, 6430709P13Rik, NHE8
Feature Type
protein coding gene
Genetic Map
Chromosome 2
87.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:167421712-167477000 bp, + strand
From VEGA annotation of GRCm38

  55289 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75041  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC9A8
Gene Tree: Slc9a8

Human
homologs
SLC9A8, solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23315
neXtProt AC: NX_Q9Y2E8

Human Synonyms: NHE8, NHE-8

Human Chr (Location): 20q13.13; chr20:49812713-49892242 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(154) : Gene trapped(151) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele exhibit male infertility, impaired mucin synthesis and bicarbonate secretion in the colon, abnormal blood coagulation and increased length of the small intestine, cecum and ileum crypts.
 
Interactions
Slc9a8 interacts with 250 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cation transport, hydrogen ion transmembrane transport, ...
Component Golgi apparatus, integral component of membrane, ...
Function antiporter activity, potassium:proton antiporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (121)    Tissues (121)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
cDNA source data(86)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc9a8 ; ZFIN slc9a8    NEW 
Molecular
reagents
All nucleic(87) cDNA(86) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000001141 (Evidence)
Ensembl Gene Model ENSMUSG00000039463 (Evidence)
Entrez Gene 77031 (Evidence)
UniGene 278924
DFCI TC1596127, TC1592783, TC1581935, TC1680564, TC1643849, TC1603066, TC1632510, TC1719727
DoTS DT.94325704, DT.94305521, DT.87048694, DT.60100203, DT.532726, DT.101390656, DT.101156086, DT.101390655
NIA Mouse Gene Index U002849
Consensus CDS Project CCDS38339.1, CCDS38340.1
International Mouse Phenotyping Consortium Status Slc9a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001141 VEGA Gene Model | MGI Sequence Detail 55289 C57BL/6J ±  kb
transcript OTTMUST00000002229 VEGA | MGI Sequence Detail 4521 Not Applicable 
polypeptide OTTMUSP00000001083 VEGA | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(21) UniProt(4)
Polymorphisms
SNPs within 2kb(272 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006153 Cation/H+ exchanger
InterPro IPR018422 Cation/H+ exchanger, CPA1 family
InterPro IPR004709 Na+/H+ exchanger
InterPro IPR018409 Na+/H+ exchanger, isoform 8, eukaryotic
Protein Ontology PR:000015220 sodium/hydrogen exchanger 8
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202781 Liu C, et al., NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion. Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C121-8
All references(45)
Other
accession IDs
MGI:1923489, MGI:2138851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory