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Slc9a8
Gene Detail
 Symbol
Name
ID
Slc9a8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
MGI:1924281
Synonyms 1200006P13Rik, 6430709P13Rik, NHE8
Feature Type protein coding gene
Genetic Map
Chromosome 2
87.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:167421712-167477000 bp, + strand
From VEGA annotation of GRCm38

  55289 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75041  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc9a8

Human
homologs
Human Homolog SLC9A8, solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
NCBI Gene ID 23315
neXtProt AC  NX_Q9Y2E8
Human Synonyms  NHE8, NHE-8
Human Chr (Location)  20q13.13; chr20:49812713-49892242 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(154) : Gene trapped(151) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit male infertility, impaired mucin synthesis and bicarbonate secretion in the colon, abnormal blood coagulation and increased length of the small intestine, cecum and ileum crypts.
 
Interactions
Slc9a8 interacts with 250 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cation transport, hydrogen ion transmembrane transport, ...
Component Golgi apparatus, integral component of membrane, ...
Function antiporter activity, potassium:proton antiporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (121)    Tissues (121)    Images (8)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 121
cDNA source data(86)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) cDNA(86) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000001141 (Evidence)
Ensembl Gene ModelENSMUSG00000039463 (Evidence)
Entrez Gene77031 (Evidence)
UniGene278924
DFCITC1581935, TC1592783, TC1596127, TC1603066, TC1632510, TC1643849, TC1680564, TC1719727
DoTSDT.101156086, DT.101390655, DT.101390656, DT.532726, DT.60100203, DT.87048694, DT.94305521, DT.94325704
NIA Mouse Gene IndexU002849
Consensus CDS ProjectCCDS38339.1, CCDS38340.1
International Mouse Knockout Project StatusSlc9a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001141 VEGA Gene Model | MGI Sequence Detail 55289 C57BL/6J ±  kb
transcript OTTMUST00000002229 VEGA | MGI Sequence Detail 4521 Not Applicable 
polypeptide OTTMUSP00000001083 VEGA | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(16) UniProt(4)
Polymorphisms SNPs within 2kb(272 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006153 Cation/H+ exchanger
InterPro IPR018422 Cation/H+ exchanger, CPA1 family
InterPro IPR004709 Na+/H+ exchanger
InterPro IPR018409 Na+/H+ exchanger, isoform 8, eukaryotic
Protein Ontology PR:000015220 sodium/hydrogen exchanger 8
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202781 Liu C, et al., NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion. Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C121-8
All references(48)
Other
accession IDs
MGI:1923489, MGI:2138851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory