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Col25a1 Gene Detail
Summary
  • Symbol
    Col25a1
  • Name
    collagen, type XXV, alpha 1
  • Synonyms
    2700062B08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924268
    NCBI Gene: 77018
Location & Maps
more
  • Sequence Map
    Chr3:130131501-130599877 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      468377 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 59.99 cM, cytoband H1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    COL25A1, collagen type XXV alpha 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COL25A1, collagen type XXV alpha 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AMY, CFEOM5, CLAC, CLACP, CLAC-P
  • Links
    NCBI Gene ID: 84570
    neXtProt AC: NX_Q9BXS0

  • Chr Location
    4q25; chr4:108808725-109302752 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human COL25A1 associations

Human Disease Mouse Models
       Fibrosis of Extraocular Muscles, Congenital, 5; CFEOM5   OMIM: 616219
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Transgenic
    2
  • Genomic Mutations
    2 involving Col25a1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022680 VEGA Gene Model | MGI Sequence Detail 468377 C57BL/6J ±  kb
transcript OTTMUST00000054365 VEGA | MGI Sequence Detail 2624 Not Applicable  
polypeptide OTTMUSP00000025948 VEGA | MGI Sequence Detail 666 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3479 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005709 collagen alpha-1(XXV) chain
  • InterPro Domains
    IPR029575 Collagen alpha-1(XXV) chain
    IPR008160 Collagen triple helix repeat
Molecular
Reagents
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  • All nucleic 9
    cDNA 8
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 23
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:206855 Tanaka T, et al., CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. J Neurosci. 2014 Jan 22;34(4):1370-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory