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Rdh10 Gene Detail
Summary
  • Symbol
    Rdh10
  • Name
    retinol dehydrogenase 10 (all-trans)
  • Synonyms
    3110069K09Rik, 4921506A21Rik, D1Ertd762e, m366Asp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924238
    NCBI Gene: 98711
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:16176106-16202774 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 4.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924238
protein coding gene Chr1:16175998-16203958 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015854
protein coding gene Chr1:13581866-13611326 (+)
A/J MGP_AJ_G0015835
protein coding gene Chr1:13429372-13457202 (+)
AKR/J MGP_AKRJ_G0015794
protein coding gene Chr1:13450835-13479744 (+)
BALB/cJ MGP_BALBcJ_G0015791
protein coding gene Chr1:13153779-13182932 (+)
C3H/HeJ MGP_C3HHeJ_G0015625
protein coding gene Chr1:13456967-13484767 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016245
protein coding gene Chr1:14197921-14225878 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013966
protein coding gene Chr1:12047757-12075861 (+)
CAST/EiJ MGP_CASTEiJ_G0015206
protein coding gene Chr1:13544041-13575658 (+)
CBA/J MGP_CBAJ_G0015598
protein coding gene Chr1:14505725-14546712 (+)
DBA/2J MGP_DBA2J_G0015697
protein coding gene Chr1:13020179-13048207 (+)
FVB/NJ MGP_FVBNJ_G0015702
protein coding gene Chr1:12840726-12868595 (+)
LP/J MGP_LPJ_G0015769
protein coding gene Chr1:13789946-13819813 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015721
protein coding gene Chr1:15161072-15189022 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016292
protein coding gene Chr1:13408707-13436625 (+)
PWK/PhJ MGP_PWKPhJ_G0014990
protein coding gene Chr1:12825781-12854731 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014771
protein coding gene Chr1:13592250-13619629 (+)
WSB/EiJ MGP_WSBEiJ_G0015269
protein coding gene Chr1:13344120-13372954 (+)



Homology
more
  • Human Ortholog
    RDH10, retinol dehydrogenase 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RDH10, retinol dehydrogenase 10
  • Synonyms
    SDR16C4
  • Links
    NCBI Gene ID: 157506
    neXtProt AC: NX_Q8IZV5
    UniProt: Q8IZV5

  • Chr Location
    8q21.11; chr8:73294602-73325281 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    124 phenotypes from 8 alleles in 13 genetic backgrounds
    9 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for null or hypomorphic alleles exhibit mid-gestational lethality, reduced Retinoic Acid signaling and abnormal limb, craniofacial, somite and cardiac morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98711 NCBI Gene Model | MGI Sequence Detail 26669 C57BL/6J ±  kb
    transcript NM_133832 RefSeq | MGI Sequence Detail 2295 ZRU/MplStud  
    polypeptide Q8VCH7 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 16
      Primer pair 7
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1289239, MGI:1918069, MGI:2138371, MGI:2138606, MGI:3799292
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 31
      Gene Ontology 8
      Phenotypes 38
    • Earliest
      J:21229 Ward A, et al., Disproportionate growth in mice with Igf-2 transgenes. Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10365-9
    • Latest
      J:343286 Queen R, et al., Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory