Rdh10 MGI Mouse Gene Detail - MGI:1924238 - retinol dehydrogenase 10 (all-trans)

Symbol

Rdh10
Name

retinol dehydrogenase 10 (all-trans)
Synonyms

3110069K09Rik, 4921506A21Rik, D1Ertd762e, m366Asp

Feature Type

protein coding gene
IDs

MGI:1924238
NCBI Gene: 98711
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:16176106-16202774 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 4.94 cM
Mapping Data

4 experiments

SNPs within 2kb

629 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924238	protein coding gene	Chr1:16175998-16203958 (+)
129S1/SvImJ	ENSMUSG00200018437	protein coding gene	Chr1:13550589-13578570 (+)
A/J	ENSMUSG00195027056	protein coding gene	Chr1:13352063-13380019 (+)
AKR/J	ENSMUSG00220008018	protein coding gene	Chr1:13398764-13426722 (+)
BALB/cJ	ENSMUSG00180024746	protein coding gene	Chr1:13418407-13446364 (+)
C3H/HeJ	ENSMUSG00175000095	protein coding gene	Chr1:13344503-13372458 (+)
C57BL/6NJ	ENSMUSG00215010679	protein coding gene	Chr1:13388298-13416260 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013966	protein coding gene	Chr1:12047757-12075861 (+)
CAST/EiJ	ENSTCUG00005021818	protein coding gene	Chr1:13693397-13722693 (+)
CBA/J	ENSMUSG00210002590	protein coding gene	Chr1:13210278-13238233 (+)
DBA/2J	ENSMUSG00185003787	protein coding gene	Chr1:14274073-14302042 (+)
FVB/NJ	ENSMUSG00205014899	protein coding gene	Chr1:13451082-13479035 (+)
JF1/MsJ	ENSUMUG00000014879	protein coding gene	Chr1:13546266-13574491 (+)
LP/J	ENSMUSG00230015735	protein coding gene	Chr1:14251891-14279869 (+)
NOD/ShiLtJ	ENSMUSG00190025547	protein coding gene	Chr1:13319797-13347750 (+)
NZO/HlLtJ	ENSMUSG00225004668	protein coding gene	Chr1:17650055-17679012 (+)
PWK/PhJ	ENSLUMG00010021168	protein coding gene	Chr1:13148544-13177774 (+)
SPRET/EiJ	ENSMSPG00010024837	protein coding gene	Chr1:13951240-13979257 (+)
WSB/EiJ	ENSIUOG00005011583	protein coding gene	Chr1:13290223-13318188 (+)

Human Ortholog

RDH10, retinol dehydrogenase 10

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RDH10, retinol dehydrogenase 10
Synonyms

SDR16C4
Links

HGNC:19975

NCBI Gene ID: 157506

UniProt: Q8IZV5
Chr Location

8q21.11; chr8:73294602-73325281 (+) GRCh38

MGI Vertebrate Homology

Rdh10 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RDH10
Gene Tree

Rdh10

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Phenotype Summary

124 phenotypes from 8 alleles in 13 genetic backgrounds
9 images
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

2
Targeted

10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for null or hypomorphic alleles exhibit mid-gestational lethality, reduced Retinoic Acid signaling and abnormal limb, craniofacial, somite and cardiac morphology.

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All GO Annotations

38
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1175
Tissues

300
cDNA Data

16
Literature Summary

35

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RDH10

Xenbase rdh10

ZFIN rdh10a, rdh10b

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All Sequences

43
RefSeq

2
UniProt

1
CCDS

CCDS14830.1

Ensembl

ENSMUSG00000025921 (Evidence)
NCBI Gene

98711

			Length	Strain/Species	Flank
genomic	98711	NCBI Gene Model \| MGI Sequence Detail	26669	C57BL/6J	± kb
transcript	NM_133832	RefSeq \| MGI Sequence Detail	2295	ZRU/MplStud
polypeptide	Q8VCH7	UniProt \| EBI \| MGI Sequence Detail	341	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013848 retinol dehydrogenase 10

(term hierarchy)
EC

1.1.1.300
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR

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All nucleic 29

cDNA 17

Primer pair 8

Other 4

Antibodies 2

Microarray probesets 6

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MGI:1289239, MGI:1918069, MGI:2138371, MGI:2138606, MGI:3799292

Summaries

All 99

Developmental Gene Expression 35

Gene Ontology 11

Phenotypes 42
Earliest

J:21229 Ward A, et al., Disproportionate growth in mice with Igf-2 transgenes. Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10365-9
Latest

J:382961 Butler Tjaden NE, et al., Retinol dehydrogenase 10-mediated retinoic acid signaling regulates the neural crest cell microenvironment during enteric nervous system formation. Hum Mol Genet. 2026 Feb 23;35(4)

TSS for Rdh10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5993	Chr1:16175554-16175583 (+)	-537 bp
Tssr5994	Chr1:16175594-16175603 (+)	-507 bp
Tssr5995	Chr1:16175618-16175634 (+)	-480 bp
Tssr5996	Chr1:16176080-16176094 (+)	-19 bp
Tssr5997	Chr1:16176588-16176601 (+)	489 bp
Tssr5998	Chr1:16181573-16181594 (+)	5,478 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24