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Rdh10
Gene Detail
Symbol

Name
ID
Rdh10
retinol dehydrogenase 10 (all-trans)
MGI:1924238
Synonyms
3110069K09Rik, 4921506A21Rik, D1Ertd762e, m366Asp
Feature Type
protein coding gene
Genetic Map
Chromosome 1
4.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:16105774-16133734 bp, + strand
From VEGA annotation of GRCm38

  27961 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14061  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RDH10
Protein SuperFamily: 11-beta-HSD1
Gene Tree: Rdh10

Human
homologs
RDH10, retinol dehydrogenase 10 (all-trans)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 157506
neXtProt AC: NX_Q8IZV5

Human Synonyms: SDR16C4

Human Chr (Location): 8q21.11; chr8:73294602-73325285 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Embryos homozygous for null or hypomorphic alleles exhibit mid-gestational lethality, reduced Retinoic Acid signaling and abnormal limb, craniofacial, somite and cardiac morphology.
 
Phenotype Images(4)
Interactions
Rdh10 interacts with 253 markers (Mir7-1, Mir10a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process bud elongation involved in lung branching, ear development, ...
Component cell body, cytoplasm, ...
Function NADP-retinol dehydrogenase activity, oxidoreductase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (516)    Tissues (256)    Images (145)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 482
Western blot 4
RT-PCR 29
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RDH10 ; Xenbase rdh10 ; ZFIN rdh10a, rdh10b    NEW 
Molecular
reagents
All nucleic(18) cDNA(13) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000025248 (Evidence)
Ensembl Gene Model ENSMUSG00000025921 (Evidence)
Entrez Gene 98711 (Evidence)
DFCI TC1581628, TC1771629, TC1603492, TC1637121
DoTS DT.101711190, DT.101381165, DT.101381163, DT.94270616, DT.490636, DT.94149199, DT.94139310
NIA Mouse Gene Index U042148
EC 1.1.1.300
Consensus CDS Project CCDS14830.1
International Mouse Phenotyping Consortium Status Rdh10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025248 VEGA Gene Model | MGI Sequence Detail 27961 C57BL/6J ±  kb
transcript OTTMUST00000062152 VEGA | MGI Sequence Detail 3587 Not Applicable 
polypeptide OTTMUSP00000030597 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(3) UniProt(1)
Polymorphisms
SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000013848 retinol dehydrogenase 10
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:214109 Adams MK, et al., The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis. J Biol Chem. 2014 May 23;289(21):14868-80
All references(51)
Other
accession IDs
MGI:1289239, MGI:1918069, MGI:2138371, MGI:2138606, MGI:3799292

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory