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Rdh10
Gene Detail
 Symbol
Name
ID
Rdh10
retinol dehydrogenase 10 (all-trans)
MGI:1924238
Synonyms 3110069K09Rik, 4921506A21Rik, D1Ertd762e, m366Asp
Feature Type protein coding gene
Genetic Map
Chromosome 1
4.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:16105774-16133734 bp, + strand
From VEGA annotation of GRCm38

  27961 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14061  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 11-beta-HSD1
Gene Tree: Rdh10

Human
homologs
Human Homolog RDH10, retinol dehydrogenase 10 (all-trans)
NCBI Gene ID 157506
neXtProt AC  NX_Q8IZV5
Human Synonyms  SDR16C4
Human Chr (Location)  8q21.11; chr8:73294602-73325285 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for null or hypomorphic alleles exhibit mid-gestational lethality, reduced Retinoic Acid signaling and abnormal limb, craniofacial, somite and cardiac morphology.
 
Phenotype Images(4)
Interactions
Rdh10 interacts with 253 markers (Mir7-1, Mir10a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process bud elongation involved in lung branching, ear development, ...
Component cell body, cytoplasm, ...
Function NADP-retinol dehydrogenase activity, oxidoreductase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (515)    Tissues (255)    Images (143)
Theiler Stages: 11, 12, 13, 15, 17, 18, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 482
Western blot 4
RT-PCR 29
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(13) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025248 (Evidence)
Ensembl Gene ModelENSMUSG00000025921 (Evidence)
Entrez Gene98711 (Evidence)
DFCITC1581628, TC1603492, TC1637121, TC1771629
DoTSDT.101381163, DT.101381165, DT.101711190, DT.490636, DT.94139310, DT.94149199, DT.94270616
NIA Mouse Gene IndexU042148
EC1.1.1.300
Consensus CDS ProjectCCDS14830.1
International Mouse Knockout Project StatusRdh10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025248 VEGA Gene Model | MGI Sequence Detail 27961 C57BL/6J ±  kb
transcript OTTMUST00000062152 VEGA | MGI Sequence Detail 3587 Not Applicable 
polypeptide OTTMUSP00000030597 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000013848 retinol dehydrogenase 10
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:203823 Billings SE, et al., The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013 Dec;27(12):4877-89
All references(51)
Other
accession IDs
MGI:1289239, MGI:1918069, MGI:2138371, MGI:2138606, MGI:3799292

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory