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Katnal2 Gene Detail
Summary
  • Symbol
    Katnal2
  • Name
    katanin p60 subunit A-like 2
  • Synonyms
    3110023G01Rik, 4933439B08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924234
    NCBI Gene: 71206
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:76977148-77047308 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 52.02 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924234
protein coding gene Chr18:76977147-77048226 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024571
protein coding gene Chr18:77705589-77781295 (-)
A/J MGP_AJ_G0024538
protein coding gene Chr18:74305246-74375293 (-)
AKR/J MGP_AKRJ_G0024509
protein coding gene Chr18:76509687-76582583 (-)
BALB/cJ MGP_BALBcJ_G0024537
protein coding gene Chr18:74532333-74603438 (-)
C3H/HeJ MGP_C3HHeJ_G0024306
protein coding gene Chr18:76617216-76687385 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024984
protein coding gene Chr18:79750616-79829074 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022414
protein coding gene Chr18:73336493-73406134 (-)
CAST/EiJ MGP_CASTEiJ_G0023778
protein coding gene Chr18:76872941-76952915 (-)
CBA/J MGP_CBAJ_G0024275
protein coding gene Chr18:82551270-82626866 (-)
DBA/2J MGP_DBA2J_G0024405
protein coding gene Chr18:73893875-73964478 (-)
FVB/NJ MGP_FVBNJ_G0024371
protein coding gene Chr18:73250593-73321691 (-)
LP/J MGP_LPJ_G0024489
protein coding gene Chr18:77584070-77659834 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024401
protein coding gene Chr18:83839606-83916311 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025032
protein coding gene Chr18:76662056-76738586 (-)
PWK/PhJ MGP_PWKPhJ_G0023523
protein coding gene Chr18:74303575-74378932 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023327
protein coding gene Chr18:76859554-76932899 (-)
WSB/EiJ MGP_WSBEiJ_G0023842
protein coding gene Chr18:76626375-76702257 (-)



Homology
more
  • Human Ortholog
    KATNAL2, katanin catalytic subunit A1 like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KATNAL2, katanin catalytic subunit A1 like 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 83473
    neXtProt AC: NX_Q8IYT4
    UniProt: Q8IYT4

  • Chr Location
    18q21.1; chr18:46917602-47104795 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    7 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutations in this gene result in male sterility associated with defects in several aspects of spermatogenesis, including abnormalities in the initiation of sperm tail growth from the basal body, sperm head shaping, manchette movement and dissolution, acrosome attachment to the nucleus, and sperm release via spermiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025420 Ensembl Gene Model | MGI Sequence Detail 70161 C57BL/6J ±  kb
transcript ENSMUST00000126153 Ensembl | MGI Sequence Detail 1942 Not Applicable  
polypeptide ENSMUSP00000122079 Ensembl | MGI Sequence Detail 539 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 4
Other
Accession IDs
less
MGI:1918456
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:267025 Jung H, et al., Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Nat Neurosci. 2018 Sep;21(9):1218-1228

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory