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Chst1
Gene Detail
Symbol

Name
ID
Chst1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
MGI:1924219
Synonyms
2610008E20Rik, C6ST, GST-1, KSGAL6ST
Feature Type
protein coding gene
Genetic Map
Chromosome 2
51.17 cM, cytoband D-E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:92599707-92615250 bp, + strand
From VEGA annotation of GRCm38

  15544 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2711  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHST1
Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst1

Human
homologs
CHST1, carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8534
neXtProt AC: NX_O43916

Human Synonyms: C6ST, GST-1, KS6ST, KSGal6ST, KSST

Human Chr (Location): 11p11.2; chr11:45647689-45665656 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Chst1 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased male sibling aggression when house together, a small decrease in the peripheral and mesenteric lymph nodes and peripheral blood and a small increase in the peripheral lymph nodes and peripheral blood.
 
Interactions
Chst1 interacts with 143 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (110)    Tissues (98)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 108
RT-PCR 2
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase chst1 ; ZFIN chst1    NEW 
Molecular
reagents
All nucleic(25) cDNA(23) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014572 (Evidence)
Ensembl Gene Model ENSMUSG00000027221 (Evidence)
Entrez Gene 76969 (Evidence)
UniGene 38021
DFCI TC1580563, TC1606373
DoTS DT.101378029, DT.481588
NIA Mouse Gene Index U002142
EC 2.8.2.-, 2.8.2.21
Consensus CDS Project CCDS16450.1
International Mouse Phenotyping Consortium Status Chst1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014572 VEGA Gene Model | MGI Sequence Detail 15544 C57BL/6J ±  kb
transcript OTTMUST00000034542 VEGA | MGI Sequence Detail 2680 Not Applicable 
polypeptide OTTMUSP00000015459 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016469 Carbohydrate sulfotransferase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000005469 carbohydrate sulfotransferase 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204813 Patnode ML, et al., KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology. 2013 Mar;23(3):381-94
All references(36)
Other
accession IDs
MGI:2139320

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory