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Chst1
Gene Detail
 Symbol
Name
ID
Chst1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
MGI:1924219
Synonyms 2610008E20Rik, C6ST, GST-1, KSGAL6ST
Feature Type protein coding gene
Genetic Map
Chromosome 2
51.17 cM, cytoband D-E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:92599707-92615250 bp, + strand
From VEGA annotation of GRCm38

  15544 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2711  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst1

Human
homologs
Human Homolog CHST1, carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
NCBI Gene ID 8534
neXtProt AC  NX_O43916
Human Synonyms  C6ST, GST-1, KS6ST, KSGal6ST, KSST
Human Chr (Location)  11p11.2; chr11:45647689-45665656 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Chst1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased male sibling aggression when house together, a small decrease in the peripheral and mesenteric lymph nodes and peripheral blood and a small increase in the peripheral lymph nodes and peripheral blood.
 
Interactions
Chst1 interacts with 143 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process carbohydrate metabolic process, galactose metabolic process, ...
Component Golgi apparatus, Golgi membrane, ...
Function keratan sulfotransferase activity, sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (110)    Tissues (98)    Images (18)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 108
RT-PCR 2
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(23) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014572 (Evidence)
Ensembl Gene ModelENSMUSG00000027221 (Evidence)
Entrez Gene76969 (Evidence)
UniGene38021
DFCITC1580563, TC1606373
DoTSDT.101378029, DT.481588
NIA Mouse Gene IndexU002142
EC2.8.2.21
Consensus CDS ProjectCCDS16450.1
International Mouse Knockout Project StatusChst1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014572 VEGA Gene Model | MGI Sequence Detail 15544 C57BL/6J ±  kb
transcript OTTMUST00000034542 VEGA | MGI Sequence Detail 2680 Not Applicable 
polypeptide OTTMUSP00000015459 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016469 Carbohydrate sulfotransferase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000005469 carbohydrate sulfotransferase 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204813 Patnode ML, et al., KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology. 2013 Mar;23(3):381-94
All references(36)
Other
accession IDs
MGI:2139320

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory