Arrdc5 MGI Mouse Gene Detail - MGI:1924170 - arrestin domain containing 5

Symbol

Arrdc5
Name

arrestin domain containing 5
Synonyms

1700013E09Rik

Feature Type

protein coding gene
IDs

MGI:1924170
NCBI Gene: 76920
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:56601111-56607262 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.26 cM, cytoband D
Mapping Data

2 experiments

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924170	protein coding gene	Chr17:56601111-56607286 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023923	protein coding gene	Chr17:57976526-57982704 (-)
A/J	MGP_AJ_G0023881	protein coding gene	Chr17:56392398-56398571 (-)
AKR/J	MGP_AKRJ_G0023850	protein coding gene	Chr17:57081934-57090327 (-)
BALB/cJ	MGP_BALBcJ_G0023882	protein coding gene	Chr17:56215172-56221345 (-)
C3H/HeJ	MGP_C3HHeJ_G0023646	protein coding gene	Chr17:57793025-57799202 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024328	protein coding gene	Chr17:60242066-60248239 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021774	protein coding gene	Chr17:52881182-52887835 (-)
CAST/EiJ	MGP_CASTEiJ_G0023128	protein coding gene	Chr17:58094953-58101143 (-)
CBA/J	MGP_CBAJ_G0023622	protein coding gene	Chr17:62574733-62581100 (-)
DBA/2J	MGP_DBA2J_G0023750	protein coding gene	Chr17:55102116-55108289 (-)
FVB/NJ	MGP_FVBNJ_G0023716	protein coding gene	Chr17:54633151-54639305 (-)
LP/J	MGP_LPJ_G0023832	protein coding gene	Chr17:58660167-58666337 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023744	protein coding gene	Chr17:62088106-62094278 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024372	protein coding gene	Chr17:57450252-57456425 (-)
PWK/PhJ	MGP_PWKPhJ_G0022874	protein coding gene	Chr17:54451740-54458340 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022685	protein coding gene	Chr17:54207689-54213793 (-)
WSB/EiJ	MGP_WSBEiJ_G0023194	protein coding gene	Chr17:58056751-58062919 (-)

Human Ortholog

ARRDC5, arrestin domain containing 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARRDC5, arrestin domain containing 5
Links

HGNC:31407

NCBI Gene ID: 645432

neXtProt AC: NX_A6NEK1

UniProt: A6NEK1
Chr Location

19p13.3; chr19:4890437-4916820 (-) GRCh38

MGI Vertebrate Homology

Arrdc5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ARRDC5
Gene Tree

Arrdc5

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Endonuclease-mediated

5
Gene trapped

33
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit oligoasthenoteratospermia, impaired acrosome reaction, impaired sperm penetration of zona pellucida, and defective spermiogenesis.

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS28902.1

Ensembl

ENSMUSG00000073380 (Evidence)
NCBI Gene

76920

			Length	Strain/Species	Flank
genomic	76920	NCBI Gene Model \| MGI Sequence Detail	6152	C57BL/6J	± kb
transcript	NM_029799	RefSeq \| MGI Sequence Detail	1032	C57BL/6
polypeptide	Q497K5	UniProt \| EBI \| MGI Sequence Detail	325	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029284 arrestin domain-containing protein 5

(term hierarchy)
InterPro Domains

IPR011022 Arrestin C-terminal-like domain

IPR014752 Arrestin-like, C-terminal

IPR011021 Arrestin-like, N-terminal

IPR014756 Immunoglobulin E-set

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All nucleic 12

cDNA 12

Microarray probesets 3

Summaries

All 33

Gene Ontology 1

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:343794 Liu R, et al., ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1. Development. 2023 Dec 15;150(24):dev201959

TSS for Arrdc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148789	Chr17:56608162-56608202 (-)	-920 bp
Tssr148788	Chr17:56607288-56607297 (-)	-31 bp
Tssr148787	Chr17:56607252-56607270 (-)	1 bp
Tssr148786	Chr17:56607229-56607248 (-)	23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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