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Cers2 Gene Detail
Summary
  • Symbol
    Cers2
  • Name
    ceramide synthase 2
  • Synonyms
    0610013I17Rik, CerS2, Lass2, Trh3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924143
    NCBI Gene: 76893
  • Gene Overview
    MyGene.info: CERS2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:95314791-95323599 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8809 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CERS2, ceramide synthase 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CERS2, ceramide synthase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    L3, LASS2, SP260, TMSG1
  • Links
    NCBI Gene ID: 29956
    neXtProt AC: NX_Q96G23
    UniProt: Q96G23

  • Chr Location
    1q21.3; chr1:150965173-150975003 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    2 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit abnormal ceramide species and myelin sheath defects and develop hepatocellular carcinoma.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027417 VEGA Gene Model | MGI Sequence Detail 8809 C57BL/6J ±  kb
    transcript OTTMUST00000067823 VEGA | MGI Sequence Detail 2216 Not Applicable  
    polypeptide OTTMUSP00000034190 VEGA | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      17 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 245
      cDNA 243
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139649
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 6
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:255485 Li S, et al., Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. Sci Rep. 2017 Oct 18;7(1):13427

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory