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Cers2 Gene Detail
Summary
  • Symbol
    Cers2
  • Name
    ceramide synthase 2
  • Synonyms
    0610013I17Rik, CerS2, Lass2, Trh3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924143
    NCBI Gene: 76893
  • Gene Overview
    MyGene.info: CERS2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95314805-95323599 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924143
protein coding gene Chr3:95314791-95323599 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027582
protein coding gene Chr3:96039141-96047852 (+)
A/J MGP_AJ_G0027541
protein coding gene Chr3:93058141-93070353 (+)
AKR/J MGP_AKRJ_G0027508
protein coding gene Chr3:95213314-95222052 (+)
BALB/cJ MGP_BALBcJ_G0027553
protein coding gene Chr3:92834659-92843427 (+)
C3H/HeJ MGP_C3HHeJ_G0027286
protein coding gene Chr3:95490304-95499007 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028001
protein coding gene Chr3:99596037-99606688 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025341
protein coding gene Chr3:89421217-89430068 (+)
CAST/EiJ MGP_CASTEiJ_G0026736
protein coding gene Chr3:94784212-94794676 (+)
CBA/J MGP_CBAJ_G0027263
protein coding gene Chr3:103217267-103228697 (+)
DBA/2J MGP_DBA2J_G0027402
protein coding gene Chr3:92348681-92357775 (+)
FVB/NJ MGP_FVBNJ_G0027373
protein coding gene Chr3:90424625-90434006 (+)
LP/J MGP_LPJ_G0027511
protein coding gene Chr3:97344378-97354443 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027400
protein coding gene Chr3:109316703-109326391 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028055
protein coding gene Chr3:94863316-94873060 (+)
PWK/PhJ MGP_PWKPhJ_G0026464
protein coding gene Chr3:92232297-92241131 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026285
protein coding gene Chr3:93160418-93169237 (+)
WSB/EiJ MGP_WSBEiJ_G0026818
protein coding gene Chr3:95251374-95260158 (+)



Homology
more
  • Human Ortholog
    CERS2, ceramide synthase 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CERS2, ceramide synthase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    L3, LASS2, SP260, TMSG1
  • Links
    NCBI Gene ID: 29956
    neXtProt AC: NX_Q96G23
    UniProt: Q96G23

  • Chr Location
    1q21.3; chr1:150965173-150975003 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    2 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit abnormal ceramide species and myelin sheath defects and develop hepatocellular carcinoma.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76893 NCBI Gene Model | MGI Sequence Detail 8795 C57BL/6J ±  kb
    transcript NM_029789 RefSeq | MGI Sequence Detail 2127 C57BL/6  
    polypeptide Q924Z4 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 246
      cDNA 244
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139649
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 7
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:255485 Li S, et al., Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. Sci Rep. 2017 Oct 18;7(1):13427

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory