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Cers2
Gene Detail
 Symbol
Name
ID
Cers2
ceramide synthase 2
MGI:1924143
Synonyms 0610013I17Rik, CerS2, Lass2, Trh3
Feature Type protein coding gene
Genetic Map
Chromosome 3
40.74 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:95314791-95323599 bp, + strand
From VEGA annotation of GRCm38

  8809 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39581  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: longevity assurance protein LAG1/LAC1
Gene Tree: Cers2

Human
homologs
Human Homolog CERS2, ceramide synthase 2
NCBI Gene ID 29956
neXtProt AC  NX_Q96G23
Human Synonyms  L3, LASS2, SP260, TMSG1
Human Chr (Location)  1q21.3; chr1:150965173-150975003 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(57) : Gene trapped(57)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trapped allele exhibit abnormal ceramide species and myelin sheath defects and develop hepatocellular carcinoma.
 
Phenotype Images(2)
Interactions
Cers2 interacts with 146 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process ceramide biosynthetic process, lipid metabolic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function DNA binding, sphingosine N-acyltransferase activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (14)    Tissues (4)    Images (3)
Theiler Stages: 15, 19, 25, 28
Assay TypeResults
RNA in situ 2
In situ reporter (knock in) 2
RT-PCR 10
cDNA source data(242)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(243) cDNA(242) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027417 (Evidence)
Ensembl Gene ModelENSMUSG00000015714 (Evidence)
Entrez Gene76893 (Evidence)
UniGene181009
DFCITC1572043, TC1732634
NIA Mouse Gene IndexU003566
Consensus CDS ProjectCCDS17612.1
International Mouse Knockout Project StatusCers2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027417 VEGA Gene Model | MGI Sequence Detail 8809 C57BL/6J ±  kb
transcript OTTMUST00000067823 VEGA | MGI Sequence Detail 2216 Not Applicable 
polypeptide OTTMUSP00000034190 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR016439 Longevity assurance, LAG1/LAC1
InterPro IPR006634 TRAM/LAG1/CLN8 homology domain
Protein Ontology PR:000009678 ceramide synthase 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204907 Park WJ, et al., Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization. J Biol Chem. 2013 Oct 25;288(43):30904-16
All references(49)
Other
accession IDs
MGI:2139649

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory