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Cyfip2
Gene Detail
Symbol

Name
ID
Cyfip2
cytoplasmic FMR1 interacting protein 2
MGI:1924134
Synonyms
1500004I01Rik, 6430511D02Rik, mKIAA1168, Pir121
Feature Type
protein coding gene
Genetic Map
Chromosome 11
27.61 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:46193855-46312294 bp, - strand
From VEGA annotation of GRCm38

  118440 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7936  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYFIP2
Protein SuperFamily: cytoplasmic FMR1-interacting protein
Gene Tree: Cyfip2

Human
homologs
CYFIP2, cytoplasmic FMR1 interacting protein 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 26999
neXtProt AC: NX_Q96F07

Human Synonyms: PIR121

Human Chr (Location): 5q33.3; chr5:157266080-157395598 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for knock-out allele exhibit complete neonatal lethality. Mice homozygous for a dmonient spontaneous mutation exhibit impaired behavioral response to cocaine, fewer dendritic spines and reduced miniature excitatory postsynaptic current frequency.
 
Interactions
Cyfip2 interacts with 335 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process activation of cysteine-type endopeptidase activity, apoptotic process, ...
Component cell junction, cytoplasm, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (261)    Tissues (68)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 261
cDNA source data(17)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cyfip2 ; ZFIN cyfip2    NEW 
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(17)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000005492 (Evidence)
Ensembl Gene Model ENSMUSG00000020340 (Evidence)
Entrez Gene 76884 (Evidence)
DoTS DT.94287387, DT.492350, DT.482968, DT.101737270, DT.97359654
Consensus CDS Project CCDS24573.1
International Mouse Phenotyping Consortium Status Cyfip2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005492 VEGA Gene Model | MGI Sequence Detail 118440 C57BL/6J ±  kb
transcript OTTMUST00000012223 VEGA | MGI Sequence Detail 6298 Not Applicable 
polypeptide OTTMUSP00000005638 VEGA | MGI Sequence Detail 1253 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(12) UniProt(7)
Polymorphisms
SNPs within 2kb(894 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008081 Cytoplasmic FMR1-interacting
Protein Ontology PR:000006091 cytoplasmic FMR1-interacting protein 2
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:219363 Han K, et al., Fragile X-like behaviors and abnormal cortical dendritic spines in Cytoplasmic FMR1-interacting protein 2-mutant mice. Hum Mol Genet. 2015 Apr 1;24(7):1813-23
All references(43)
Other
accession IDs
MGI:1923743, MGI:2144048, MGI:2144412

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory