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Spopl Gene Detail
Summary
  • Symbol
    Spopl
  • Name
    speckle-type BTB/POZ protein-like
  • Synonyms
    4921517N04Rik, E430033K04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924107
    NCBI Gene: 76857
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:23506220-23572106 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 15.48 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924107
protein coding gene Chr2:23506220-23572129 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025400
protein coding gene Chr2:21270938-21338540 (-)
A/J MGP_AJ_G0025378
protein coding gene Chr2:20442025-20514538 (-)
AKR/J MGP_AKRJ_G0025347
protein coding gene Chr2:21130820-21200370 (-)
BALB/cJ MGP_BALBcJ_G0025373
protein coding gene Chr2:20533746-20604267 (-)
C3H/HeJ MGP_C3HHeJ_G0025134
protein coding gene Chr2:21067697-21134844 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025817
protein coding gene Chr2:21891241-21963028 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023229
protein coding gene Chr2:19477757-19539636 (-)
CAST/EiJ MGP_CASTEiJ_G0024597
protein coding gene Chr2:20953881-21024120 (-)
CBA/J MGP_CBAJ_G0025112
protein coding gene Chr2:22751449-22818330 (-)
DBA/2J MGP_DBA2J_G0025245
protein coding gene Chr2:20304759-20368455 (-)
FVB/NJ MGP_FVBNJ_G0025207
protein coding gene Chr2:20068980-20132291 (-)
LP/J MGP_LPJ_G0025331
protein coding gene Chr2:21223570-21293525 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025238
protein coding gene Chr2:22849469-22921335 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025876
protein coding gene Chr2:21060261-21127447 (-)
PWK/PhJ MGP_PWKPhJ_G0024346
protein coding gene Chr2:20123567-20189471 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024146
protein coding gene Chr2:21131573-21214491 (-)
WSB/EiJ MGP_WSBEiJ_G0024667
protein coding gene Chr2:21165265-21228577 (-)



Homology
more
  • Human Ortholog
    SPOPL, speckle type BTB/POZ protein like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPOPL, speckle type BTB/POZ protein like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTBD33
  • Links
    NCBI Gene ID: 339745
    neXtProt AC: NX_Q6IQ16
    UniProt: Q6IQ16

  • Chr Location
    2q22.1; chr2:138501780-138573235 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile with no gross morphological and skeletal defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026771 Ensembl Gene Model | MGI Sequence Detail 65887 C57BL/6J ±  kb
transcript ENSMUST00000132484 Ensembl | MGI Sequence Detail 6595 Not Applicable  
polypeptide ENSMUSP00000114974 Ensembl | MGI Sequence Detail 392 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
less
MGI:2139149, MGI:2139449, MGI:2444012
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:251822 Cai H, et al., Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord. Dev Biol. 2017 Dec 1;432(1):72-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory