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Catsper3 Gene Detail
Summary
  • Symbol
    Catsper3
  • Name
    cation channel, sperm associated 3
  • Synonyms
    4921522D01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924106
    NCBI Gene: 76856
Location & Maps
more
  • Sequence Map
    Chr13:55784568-55808998 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24431 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CATSPER3, cation channel, sperm associated 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CATSPER3, cation channel, sperm associated 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CACRC
  • Links
    NCBI Gene ID: 347732
    neXtProt AC: NX_Q86XQ3

  • Chr Location
    5q31.1; chr5:134967906-135011707 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Catsper3
  • Incidental Mutations
Mice homozygous for this mutation are viable and exhibit no gross physical or behavioral abnormality. Although wild-type and homozygous mutant females bred to wild-type males exhibit similar fertility, male homozygotes are infertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027746 VEGA Gene Model | MGI Sequence Detail 24431 C57BL/6J ±  kb
transcript OTTMUST00000068658 VEGA | MGI Sequence Detail 1330 Not Applicable  
polypeptide OTTMUSP00000034759 VEGA | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    105 from dbSNP Build 137
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000000671 cation channel sperm-associated protein 3
  • InterPro Domains
    IPR005821 Ion transport domain
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:182472 Chung JJ, et al., A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan 11;2:153

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory