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Slc17a5
Gene Detail
 Symbol
Name
ID
Slc17a5
solute carrier family 17 (anion/sugar transporter), member 5
MGI:1924105
Synonyms 4631416G20Rik
Feature Type protein coding gene
Genetic Map
Chromosome 9
43.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:78536488-78588041 bp, - strand
From VEGA annotation of GRCm38

  51554 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56571  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc17a5

Human
homologs
Human Homolog SLC17A5, solute carrier family 17 (acidic sugar transporter), member 5
NCBI Gene ID 26503
neXtProt AC  NX_Q9NRA2
Human Synonyms  AST, ISSD, NSD, SD, SIALIN, SIASD, SLD
Human Chr (Location)  6q13; chr6:73593379-73654014 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SLC17A5
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Radiation induced(1) Targeted(3)
Genomic Mutations involving Slc17a5 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit numerous neurological abnormalities, including impaired exploratory and locomotor activity, hearing deficits, and an increased depressive-like response.
 
Human Diseases Modeled Using Mouse Slc17a5 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Slc17a5 interacts with 203 markers (Mir7-1, Mir7-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process amino acid transport, ion transmembrane transport, ...
Component cell junction, cytoplasm, ...
Function sialic acid transmembrane transporter activity, symporter activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (226)    Tissues (194)    Images (1)
Theiler Stages: 19, 21, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 220
RNA in situ 1
Western blot 5
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(40) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030755 (Evidence)
Ensembl Gene ModelENSMUSG00000049624 (Evidence)
Entrez Gene235504 (Evidence)
UniGene46932
DFCITC1580198, TC1596177, TC1746563
DoTSDT.101377794, DT.101377795, DT.101725815, DT.528732
NIA Mouse Gene IndexU031122
Consensus CDS ProjectCCDS23364.1, CCDS72283.1
International Mouse Knockout Project StatusSlc17a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030755 VEGA Gene Model | MGI Sequence Detail 51554 C57BL/6J ±  kb
transcript OTTMUST00000076135 VEGA | MGI Sequence Detail 3236 Not Applicable 
polypeptide OTTMUSP00000040029 VEGA | MGI Sequence Detail 495 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(9) UniProt(1)
Polymorphisms SNPs within 2kb(408 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
Protein Ontology PR:000014961 sialin
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200994 Lodder-Gadaczek J, et al., Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5). Biochem J. 2013 Aug 15;454(1):31-8
All references(41)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory