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Slc17a5 Gene Detail
Summary
  • Symbol
    Slc17a5
  • Name
    solute carrier family 17 (anion/sugar transporter), member 5
  • Synonyms
    4631416G20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924105
    NCBI Gene: 235504
  • Gene Overview
    MyGene.info: SLC17A5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:78536488-78588041 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51554 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.65 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLC17A5, solute carrier family 17 member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC17A5, solute carrier family 17 member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AST, ISSD, NSD, SD, SIALIN, SIASD, SLD
  • Links
    NCBI Gene ID: 26503
    neXtProt AC: NX_Q9NRA2
    UniProt: Q9NRA2

  • Chr Location
    6q13; chr6:73593378-73654014 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Slc17a5 mouse models; 1 with human SLC17A5 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 1 allele in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit numerous neurological abnormalities, including impaired exploratory and locomotor activity, hearing deficits, and an increased depressive-like response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030755 VEGA Gene Model | MGI Sequence Detail 51554 C57BL/6J ±  kb
    transcript OTTMUST00000076135 VEGA | MGI Sequence Detail 3236 Not Applicable  
    polypeptide OTTMUSP00000040029 VEGA | MGI Sequence Detail 495 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      403 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 41
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:262131 Stroobants S, et al., Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice. Exp Neurol. 2017 May;291:106-119

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory