Slc17a5
Gene Detail

Symbol Name ID

Slc17a5 solute carrier family 17 (anion/sugar transporter), member 5 MGI:1924105

Synonyms

4631416G20Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 9

43.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:78536488-78588041 bp, - strand From VEGA annotation of GRCm38   51554 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc17a5 ± 2 cM)

Gene Tree: Slc17a5

Human ortholog

SLC17A5 solute carrier family 17 (anion/sugar transporter), member 5 NCBI Gene ID 26503
Human Synonyms: AST, ISSD, NSD, SD, SIALIN, SIASD, SLD
Human Chr6:74303102-74363737 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SLC17A5 (2)

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

Homozygous mutant mice exhibit numerous neurological abnormalities, including impaired exploratory and locomotor activity, hearing deficits, and an increased depressive-like response.

 
Human Diseases Modeled Using Mouse Slc17a5 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	amino acid transport, sialic acid transport, ...
Component	cell junction, cytoplasmic membrane-bounded vesicle, ...
Function	sialic acid transmembrane transporter activity, symporter activity

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (226)    Tissues (194)    Images (1)
Theiler Stages: 19, 21, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	220
RNA in situ	1
Western blot	5

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) cDNA(40) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030755 (Evidence)
Ensembl Gene Model	ENSMUSG00000049624 (Evidence)
Entrez Gene	235504 (Evidence)
UniGene	46932
DFCI	TC1580198, TC1596177, TC1746563
DoTS	DT.101377794, DT.101377795, DT.101725815, DT.528732
NIA Mouse Gene Index	U031122
Consensus CDS Project	CCDS23364.1
International Mouse Knockout Project Status	Slc17a5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030755	VEGA Gene Model | MGI Sequence Detail	51554	C57BL/6J
transcript	OTTMUST00000076135	VEGA | MGI Sequence Detail	3236	Not Applicable
polypeptide	OTTMUSP00000040029	VEGA | MGI Sequence Detail	495	Not Applicable

All sequences(37) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(201 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
Protein Ontology	PR:000014961	sialin

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)