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Gper1
Gene Detail
Symbol

Name
ID
Gper1
G protein-coupled estrogen receptor 1
MGI:1924104
Synonyms
6330420K13Rik, Ceprl, CMKRL2, FEG-1, GPCR-Br, Gper, Gpr30
Feature Type
protein coding gene
Genetic Map
Chromosome 5
78.58 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:139423151-139427800 bp, + strand
From VEGA annotation of GRCm38

  4650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15855  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPER1
Protein SuperFamily: G protein-coupled estrogen receptor 1
Gene Tree: Gper1

Human
homologs
GPER1, G protein-coupled estrogen receptor 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2852
neXtProt AC: NX_Q99527

Human Synonyms: CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR, mER

Human Chr (Location): 7p22.3; chr7:1086807-1093815 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knockout allele exhibit decreased thymic atrophy, insulin, and glucagon responses following treatment with PGE2.
 
Interactions
Gper1 interacts with 97 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (120 annotations)
Process apoptotic chromosome condensation, apoptotic process, ...
Component axon, axon terminus, ...
Function chromatin binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (4)    Tissues (3)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 2
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase gper1 ; ZFIN gper1    NEW 
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021296 (Evidence)
Ensembl Gene Model ENSMUSG00000053647 (Evidence)
Entrez Gene 76854 (Evidence)
UniGene 389706
DFCI TC1581528
DoTS DT.55137659
NIA Mouse Gene Index U006362
Consensus CDS Project CCDS19811.1
International Mouse Phenotyping Consortium Status Gper1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021296 VEGA Gene Model | MGI Sequence Detail 4650 C57BL/6J ±  kb
transcript OTTMUST00000050492 VEGA | MGI Sequence Detail 2537 Not Applicable 
polypeptide OTTMUSP00000023577 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001111 G-protein coupled estrogen receptor 1
References
(Earliest) J:38628 Feng Y, et al., Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors. Biochem Biophys Res Commun. 1997 Feb 24;231(3):651-4
(Latest) J:216705 Marjon NA, et al., G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis. Mol Cancer Res. 2014 Nov;12(11):1644-54
All references(62)
Other
accession IDs
MGD-MRK-38426, MGI:109381

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory