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Gper1
Gene Detail
 Symbol
Name
ID
Gper1
G protein-coupled estrogen receptor 1
MGI:1924104
Synonyms 6330420K13Rik, Ceprl, CMKRL2, FEG-1, GPCR-Br, Gper, Gpr30
Feature Type protein coding gene
Genetic Map
Chromosome 5
78.58 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:139423151-139427800 bp, + strand
From VEGA annotation of GRCm38

  4650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15855  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled estrogen receptor 1
Gene Tree: Gper1

Human
homologs
Human Homolog GPER1, G protein-coupled estrogen receptor 1
NCBI Gene ID 2852
neXtProt AC  NX_Q99527
Human Synonyms  CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR, mER
Human Chr (Location)  7p22.3; chr7:1086807-1093815 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knockout allele exhibit decreased thymic atrophy, insulin, and glucagon responses following treatment with PGE2.
 
Interactions
Gper1 interacts with 97 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (119 annotations)
Process apoptotic chromosome condensation, apoptotic process, ...
Component axon, axon terminus, ...
Function chromatin binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (4)    Tissues (3)    Images (2)
Theiler Stages: 13, 23, 25
Assay TypeResults
RNA in situ 2
RT-PCR 2
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021296 (Evidence)
Ensembl Gene ModelENSMUSG00000053647 (Evidence)
Entrez Gene76854 (Evidence)
UniGene389706
DFCITC1581528
DoTSDT.55137659
NIA Mouse Gene IndexU006362
Consensus CDS ProjectCCDS19811.1
International Mouse Knockout Project StatusGper1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021296 VEGA Gene Model | MGI Sequence Detail 4650 C57BL/6J ±  kb
transcript OTTMUST00000050492 VEGA | MGI Sequence Detail 2537 Not Applicable 
polypeptide OTTMUSP00000023577 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001111 G-protein coupled estrogen receptor 1
References (Earliest) J:38628 Feng Y, et al., Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors. Biochem Biophys Res Commun. 1997 Feb 24;231(3):651-4
(Latest) J:203948 Sharma G, et al., GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinology. 2013 Nov;154(11):4136-45
All references(59)
Other
accession IDs
MGD-MRK-38426, MGI:109381

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory