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Ago4 Gene Detail
Summary
  • Symbol
    Ago4
  • Name
    argonaute RISC catalytic subunit 4
  • Synonyms
    5730550L01Rik, argonaute 4, Eif2c4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924100
    NCBI Gene: 76850
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:126489541-126533472 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 60.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924100
protein coding gene Chr4:126489541-126533585 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028782
protein coding gene Chr4:128172139-128217313 (-)
A/J MGP_AJ_G0028741
protein coding gene Chr4:123132873-123176871 (-)
AKR/J MGP_AKRJ_G0028694
protein coding gene Chr4:126514186-126558393 (-)
BALB/cJ MGP_BALBcJ_G0028764
protein coding gene Chr4:123704975-123749232 (-)
C3H/HeJ MGP_C3HHeJ_G0028478
protein coding gene Chr4:126575599-126620381 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029206
protein coding gene Chr4:133062831-133110486 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026479
protein coding gene Chr4:116259522-116306406 (-)
CAST/EiJ MGP_CASTEiJ_G0027911
protein coding gene Chr4:124691918-124742910 (-)
CBA/J MGP_CBAJ_G0028444
protein coding gene Chr4:136264134-136319531 (-)
DBA/2J MGP_DBA2J_G0028593
protein coding gene Chr4:123581091-123625279 (-)
FVB/NJ MGP_FVBNJ_G0028560
protein coding gene Chr4:122235925-122280213 (-)
LP/J MGP_LPJ_G0028694
protein coding gene Chr4:128460999-128506530 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028586
protein coding gene Chr4:141302544-141350836 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029244
protein coding gene Chr4:126871651-126916970 (-)
PWK/PhJ MGP_PWKPhJ_G0027632
protein coding gene Chr4:120071080-120118144 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027458
protein coding gene Chr4:122697010-122746042 (-)
WSB/EiJ MGP_WSBEiJ_G0027991
protein coding gene Chr4:126980546-127026744 (-)



Homology
more
  • Human Ortholog
    AGO4, argonaute RISC catalytic component 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AGO4, argonaute RISC catalytic component 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EIF2C4
  • Links
    NCBI Gene ID: 192670
    neXtProt AC: NX_Q9HCK5
    UniProt: Q9HCK5

  • Chr Location
    1p34.3; chr1:35807630-35857890 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for a null mutation display oligozoospermia, decreased testis weight, premature entry into meiosis and disruption of sex body formation. However both males and females are fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042500 Ensembl Gene Model | MGI Sequence Detail 43932 C57BL/6J ±  kb
    transcript ENSMUST00000084289 Ensembl | MGI Sequence Detail 6537 Not Applicable  
    polypeptide ENSMUSP00000081312 Ensembl | MGI Sequence Detail 861 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 25
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2140312
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:187588 Modzelewski AJ, et al., AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline. Dev Cell. 2012 Aug 14;23(2):251-64

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory