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Dtl Gene Detail
Summary
  • Symbol
    Dtl
  • Name
    denticleless E3 ubiquitin protein ligase
  • Synonyms
    2810047L02Rik, 5730564G15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924093
    NCBI Gene: 76843
  • Gene Overview
    MyGene.info: DTL
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:191269468-191307656 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 96.44 cM, cytoband H6
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924093
protein coding gene Chr1:191269468-191307656 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016945
protein coding gene Chr1:198587642-198628599 (-)
A/J MGP_AJ_G0016924
protein coding gene Chr1:190447143-190485174 (-)
AKR/J MGP_AKRJ_G0016889
protein coding gene Chr1:196106433-196146008 (-)
BALB/cJ MGP_BALBcJ_G0016882
protein coding gene Chr1:191127751-191165882 (-)
C3H/HeJ MGP_C3HHeJ_G0016706
protein coding gene Chr1:196947071-196985548 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017345
protein coding gene Chr1:204922170-204961552 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015052
protein coding gene Chr1:181340714-181381327 (-)
CAST/EiJ MGP_CASTEiJ_G0016289
protein coding gene Chr1:196532191-196572918 (-)
CBA/J MGP_CBAJ_G0016680
protein coding gene Chr1:212513216-212553358 (-)
DBA/2J MGP_DBA2J_G0016786
protein coding gene Chr1:189165724-189203638 (-)
FVB/NJ MGP_FVBNJ_G0016782
protein coding gene Chr1:187293732-187331372 (-)
LP/J MGP_LPJ_G0016861
protein coding gene Chr1:199784885-199825274 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016814
protein coding gene Chr1:219193843-219233930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017382
protein coding gene Chr1:195969352-196007016 (-)
PWK/PhJ MGP_PWKPhJ_G0016076
protein coding gene Chr1:188457735-188497889 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015852
protein coding gene Chr1:194972930-195010931 (-)
WSB/EiJ MGP_WSBEiJ_G0016351
protein coding gene Chr1:196197381-196236722 (-)



Homology
more
  • Human Ortholog
    DTL, denticleless E3 ubiquitin protein ligase homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DTL, denticleless E3 ubiquitin protein ligase homolog
  • Synonyms
    CDT2, DCAF2, L2DTL, RAMP
  • Links
    NCBI Gene ID: 51514
    neXtProt AC: NX_Q9NZJ0
    UniProt: Q9NZJ0

  • Chr Location
    1q32.3; chr1:212035553-212105006 (+)  GRCh38.p7

  • Alliance of Genome Resources
    Dtl stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: DTL
  • Gene Tree
    Dtl
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutation of this gene results in very early embryonic lethality around or before E1.5. In vitro siRNA knockdown experiments show that the gene is essential cell survival and cell cycle progression to allow proper blastocyst formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76843 NCBI Gene Model | MGI Sequence Detail 38189 C57BL/6J ±  kb
    transcript NM_001305233 RefSeq | MGI Sequence Detail 4253 C57BL/6  
    polypeptide Q3TLR7 UniProt | EBI | MGI Sequence Detail 729 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917907
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:294392 Fan K, et al., CRL4(DCAF2) is required for mature T-cell expansion via Aurora B-regulated proteasome activity. J Autoimmun. 2019 Jan;96:74-85

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/01/2021
    MGI 6.17
    The Jackson Laboratory