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Hyls1 Gene Detail
Summary
  • Symbol
    Hyls1
  • Name
    HYLS1, centriolar and ciliogenesis associated
  • Synonyms
    3010015K02Rik, hydrolethalus syndrome 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924082
    NCBI Gene: 76832
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:35472117-35481365 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 20.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924082
protein coding gene Chr9:35472116-35481694 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034538
protein coding gene Chr9:33376230-33385807 (-)
A/J MGP_AJ_G0034516
protein coding gene Chr9:32506815-32516398 (-)
AKR/J MGP_AKRJ_G0034442
protein coding gene Chr9:33241363-33250951 (-)
BALB/cJ MGP_BALBcJ_G0034507
protein coding gene Chr9:32425144-32434721 (-)
C3H/HeJ MGP_C3HHeJ_G0034219
protein coding gene Chr9:33574651-33584225 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035028
protein coding gene Chr9:34490274-34499849 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031958
protein coding gene Chr9:31194433-31204135 (-)
CAST/EiJ MGP_CASTEiJ_G0033542
protein coding gene Chr9:33480626-33490241 (-)
CBA/J MGP_CBAJ_G0034193
protein coding gene Chr9:35646776-35656365 (-)
DBA/2J MGP_DBA2J_G0034350
protein coding gene Chr9:32490461-32500095 (-)
FVB/NJ MGP_FVBNJ_G0034293
protein coding gene Chr9:31907652-31917238 (-)
LP/J MGP_LPJ_G0034436
protein coding gene Chr9:33618653-33628246 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034337
protein coding gene Chr9:37210659-37221164 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035048
protein coding gene Chr9:33188450-33198055 (-)
PWK/PhJ MGP_PWKPhJ_G0033247
protein coding gene Chr9:32475562-32485148 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033082
protein coding gene Chr9:33338649-33348255 (-)
WSB/EiJ MGP_WSBEiJ_G0033657
protein coding gene Chr9:32962054-32971630 (-)



Homology
more
  • Human Ortholog
    HYLS1, HYLS1 centriolar and ciliogenesis associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HYLS1, HYLS1 centriolar and ciliogenesis associated
  • Synonyms
    HLS
  • Links
    NCBI Gene ID: 219844
    neXtProt AC: NX_Q96M11
    UniProt: Q96M11

  • Chr Location
    11q24.2; chr11:125883614-125900646 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human HYLS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76832 NCBI Gene Model | MGI Sequence Detail 9249 C57BL/6J ±  kb
    transcript NM_029762 RefSeq | MGI Sequence Detail 1643 C57BL/6  
    polypeptide Q9CXX0 UniProt | EBI | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008852 centriolar and ciliogenesis-associated protein HYLS1
    • InterPro Domains
      IPR026227 Centriolar and ciliogenesis-associated protein HYLS1
      IPR027918 Centriolar and ciliogenesis-associated protein HYLS1, C-terminal domain
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory