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Dok5 Gene Detail
Summary
  • Symbol
    Dok5
  • Name
    docking protein 5
  • Synonyms
    2700055C10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924079
    NCBI Gene: 76829
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:170573727-170721689 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 92.26 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    803 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924079
protein coding gene Chr2:170573722-170721695 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026938
protein coding gene Chr2:176800852-176961127 (+)
A/J MGP_AJ_G0026905
protein coding gene Chr2:169417389-169570131 (+)
AKR/J MGP_AKRJ_G0026876
protein coding gene Chr2:174498216-174649268 (+)
BALB/cJ MGP_BALBcJ_G0026914
protein coding gene Chr2:169790458-169941946 (+)
C3H/HeJ MGP_C3HHeJ_G0026656
protein coding gene Chr2:174862498-175018302 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027361
protein coding gene Chr2:181901747-182064592 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024731
protein coding gene Chr2:162710463-162861275 (+)
CAST/EiJ MGP_CASTEiJ_G0026114
protein coding gene Chr2:175501074-175664924 (+)
CBA/J MGP_CBAJ_G0026633
protein coding gene Chr2:188693800-188860257 (+)
DBA/2J MGP_DBA2J_G0026771
protein coding gene Chr2:168510511-168660451 (+)
FVB/NJ MGP_FVBNJ_G0026737
protein coding gene Chr2:167119306-167269979 (+)
LP/J MGP_LPJ_G0026872
protein coding gene Chr2:176752800-176912015 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026756
protein coding gene Chr2:191774613-191931054 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027418
protein coding gene Chr2:174452584-174612257 (+)
PWK/PhJ MGP_PWKPhJ_G0025851
protein coding gene Chr2:168249748-168405431 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025651
protein coding gene Chr2:173459161-173622563 (+)
WSB/EiJ MGP_WSBEiJ_G0026187
protein coding gene Chr2:175424184-175582362 (+)



Homology
more
  • Human Ortholog
    DOK5, docking protein 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOK5, docking protein 5
  • Synonyms
    C20orf180, IRS6, IRS-6
  • Links
    NCBI Gene ID: 55816
    neXtProt AC: NX_Q9P104
    UniProt: Q9P104

  • Chr Location
    20q13.2; chr20:54475593-54651169 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027560 Ensembl Gene Model | MGI Sequence Detail 147963 C57BL/6J ±  kb
transcript ENSMUST00000029075 Ensembl | MGI Sequence Detail 1768 Not Applicable  
polypeptide ENSMUSP00000029075 Ensembl | MGI Sequence Detail 306 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:201759 Pan Y, et al., Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis. Neurosci Lett. 2013 Oct 11;553:46-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory