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Phf12 Gene Detail
Summary
  • Symbol
    Phf12
  • Name
    PHD finger protein 12
  • Synonyms
    2410142K10Rik, mKIAA1523, PF1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924057
    NCBI Gene: 268448
  • Gene Overview
    MyGene.info: PHF12
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:77982754-78030539 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924057
protein coding gene Chr11:77982754-78030539 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018759
protein coding gene Chr11:78941391-78992527 (+)
A/J MGP_AJ_G0018725
protein coding gene Chr11:75935675-75986202 (+)
AKR/J MGP_AKRJ_G0018695
protein coding gene Chr11:78244479-78292556 (+)
BALB/cJ MGP_BALBcJ_G0018699
protein coding gene Chr11:76331778-76380193 (+)
C3H/HeJ MGP_C3HHeJ_G0018512
protein coding gene Chr11:78275610-78326656 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019150
protein coding gene Chr11:81412166-81464884 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016785
protein coding gene Chr11:72913608-72961335 (+)
CAST/EiJ MGP_CASTEiJ_G0018066
protein coding gene Chr11:78708509-78758881 (+)
CBA/J MGP_CBAJ_G0018482
protein coding gene Chr11:84965166-85017779 (+)
DBA/2J MGP_DBA2J_G0018591
protein coding gene Chr11:75520938-75568622 (+)
FVB/NJ MGP_FVBNJ_G0018581
protein coding gene Chr11:75103592-75150888 (+)
LP/J MGP_LPJ_G0018662
protein coding gene Chr11:79485647-79536735 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018607
protein coding gene Chr11:85405718-85459204 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019190
protein coding gene Chr11:78476860-78529439 (+)
PWK/PhJ MGP_PWKPhJ_G0017837
protein coding gene Chr11:76295098-76343915 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017628
protein coding gene Chr11:78079572-78133252 (+)
WSB/EiJ MGP_WSBEiJ_G0018119
protein coding gene Chr11:78290667-78341681 (+)



Homology
more
  • Human Ortholog
    PHF12, PHD finger protein 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PHF12, PHD finger protein 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PF1
  • Links
    NCBI Gene ID: 57649
    neXtProt AC: NX_Q96QT6
    UniProt: Q96QT6

  • Chr Location
    17q11.2; chr17:28905250-28951490 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10841
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PHF12
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 268448 NCBI Gene Model | MGI Sequence Detail 47786 C57BL/6J ±  kb
transcript NM_174852 RefSeq | MGI Sequence Detail 4412 C57BL/6  
polypeptide Q5SPL2 UniProt | EBI | MGI Sequence Detail 1003 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 16
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:244897 Graveline R, et al., The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence. Mol Cell Biol. 2017 Mar 01;37(5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory