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Kdm4c Gene Detail
Summary
  • Symbol
    Kdm4c
  • Name
    lysine (K)-specific demethylase 4C
  • Synonyms
    2410141F18Rik, Jmjd2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924054
    NCBI Gene: 76804
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:74160734-74324097 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 36.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    883 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924054
 protein coding gene Chr4:74160734-74324101 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028390
 protein coding gene Chr4:73518540-73689788 (+)
A/J MGP_AJ_G0028350
 protein coding gene Chr4:71030539-71195324 (+)
AKR/J MGP_AKRJ_G0028299
 protein coding gene Chr4:72760078-72922522 (+)
BALB/cJ MGP_BALBcJ_G0028370
 protein coding gene Chr4:71162029-71335233 (+)
C3H/HeJ MGP_C3HHeJ_G0028085
 protein coding gene Chr4:73363411-73532805 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028810
 protein coding gene Chr4:76303890-76492995 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026112
 protein coding gene Chr4:67466978-67634444 (+)
CAST/EiJ MGP_CASTEiJ_G0027526
 protein coding gene Chr4:71379185-71563262 (+)
CBA/J MGP_CBAJ_G0028054
 protein coding gene Chr4:78699738-78878576 (+)
DBA/2J MGP_DBA2J_G0028203
 protein coding gene Chr4:70796034-70957918 (+)
FVB/NJ MGP_FVBNJ_G0028169
 protein coding gene Chr4:69880487-70048421 (+)
LP/J MGP_LPJ_G0028303
 protein coding gene Chr4:73875216-74058037 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028198
 protein coding gene Chr4:82694216-82899662 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028846
 protein coding gene Chr4:72917062-73097806 (+)
PWK/PhJ MGP_PWKPhJ_G0027252
 protein coding gene Chr4:69256073-69427542 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027077
 protein coding gene Chr4:70345317-70521784 (+)
WSB/EiJ MGP_WSBEiJ_G0027602
 protein coding gene Chr4:72980842-73160186 (+)



Homology
more
  • Human Ortholog
    KDM4C, lysine demethylase 4C
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDM4C, lysine demethylase 4C
  • Synonyms
    GASC1, JHDM3C, JMJD2C, TDRD14C
  • Links
    NCBI Gene ID: 23081
    neXtProt AC: NX_Q9H3R0
    UniProt: Q9H3R0

  • Chr Location
    9p24.1; chr9:6720863-7175648 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human KDM4C associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null gene trap allele cannot be produced likely due to embryonic lethality. Mice heterozygous for a null gene trap allele exhibit reduced body weight and lower incidence and multiplicity of both benign and malignant tumors in mice treated with DMBA and TPA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    46
  • cDNA Data
    75
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028397 Ensembl Gene Model | MGI Sequence Detail 163364 C57BL/6J ±  kb
    transcript ENSMUST00000030102 Ensembl | MGI Sequence Detail 4196 Not Applicable  
    polypeptide ENSMUSP00000030102 Ensembl | MGI Sequence Detail 1054 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 76
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140158
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:327937 Pan HC, et al., Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury. Int J Mol Sci. 2022 Aug 18;23(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory