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Usp42 Gene Detail
Summary
  • Symbol
    Usp42
  • Name
    ubiquitin specific peptidase 42
  • Synonyms
    2410140K03Rik, 3110031A07Rik, A630018G05Rik, D5Ertd591e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924050
    NCBI Gene: 76800
  • Gene Overview
    MyGene.info: USP42
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143710325-143732280 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 82.50 cM, cytoband G2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924050
protein coding gene Chr5:143710325-143759795 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030336
protein coding gene Chr5:149071039-149093804 (-)
A/J MGP_AJ_G0030305
protein coding gene Chr5:142661284-142684106 (-)
AKR/J MGP_AKRJ_G0030237
protein coding gene Chr5:147126149-147148176 (-)
BALB/cJ MGP_BALBcJ_G0030322
protein coding gene Chr5:143910459-143932256 (-)
C3H/HeJ MGP_C3HHeJ_G0030033
protein coding gene Chr5:147950973-147974035 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030767
protein coding gene Chr5:154507068-154529050 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027985
protein coding gene Chr5:136430566-136452978 (-)
CAST/EiJ MGP_CASTEiJ_G0029438
protein coding gene Chr5:147463403-147487956 (-)
CBA/J MGP_CBAJ_G0030003
protein coding gene Chr5:160869863-160892154 (-)
DBA/2J MGP_DBA2J_G0030153
protein coding gene Chr5:142433380-142455322 (-)
FVB/NJ MGP_FVBNJ_G0030108
protein coding gene Chr5:141636843-141660972 (-)
LP/J MGP_LPJ_G0030239
protein coding gene Chr5:149677285-149699219 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030139
protein coding gene Chr5:163248504-163273047 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030807
protein coding gene Chr5:146990894-147015663 (-)
PWK/PhJ MGP_PWKPhJ_G0029153
protein coding gene Chr5:141526073-141548456 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028989
protein coding gene Chr5:144745303-144768639 (-)
WSB/EiJ MGP_WSBEiJ_G0029511
protein coding gene Chr5:147788257-147810230 (-)



Homology
more
  • Human Ortholog
    USP42, ubiquitin specific peptidase 42
  • Vertebrate Orthologs
    8
  • Human Ortholog
    USP42, ubiquitin specific peptidase 42
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 84132
    neXtProt AC: NX_Q9H9J4
    UniProt: Q9H9J4

  • Chr Location
    7p22.1; chr7:6078743-6161564 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit fecundity and behavioral abnormalities, hyperactivity, increased T cell number, abnormal lens morphology, and cataracts. Males display oligozoospermia and testis degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051306 Ensembl Gene Model | MGI Sequence Detail 21956 C57BL/6J ±  kb
    transcript ENSMUST00000053287 Ensembl | MGI Sequence Detail 5151 Not Applicable  
    polypeptide ENSMUSP00000053955 Ensembl | MGI Sequence Detail 1324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 86
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1261892, MGI:1920429, MGI:2444457
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory