Tbc1d9b MGI Mouse Gene Detail - MGI:1924045 - TBC1 domain family, member 9B

Symbol

Tbc1d9b
Name

TBC1 domain family, member 9B
Synonyms

2700008N14Rik

Feature Type

protein coding gene
IDs

MGI:1924045
NCBI Gene: 76795
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:50022223-50063612 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 30.28 cM
Mapping Data

2 experiments

SNPs within 2kb

2286 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924045	protein coding gene	Chr11:50021891-50063612 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018241	protein coding gene	Chr11:49290037-49333965 (+)
A/J	MGP_AJ_G0018209	protein coding gene	Chr11:47401755-47443182 (+)
AKR/J	MGP_AKRJ_G0018179	protein coding gene	Chr11:48910232-48954934 (+)
BALB/cJ	MGP_BALBcJ_G0018179	protein coding gene	Chr11:47682102-47724339 (+)
C3H/HeJ	MGP_C3HHeJ_G0017992	protein coding gene	Chr11:48911477-48953077 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018630	protein coding gene	Chr11:50753530-50796636 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016282	protein coding gene	Chr11:45022776-45062364 (+)
CAST/EiJ	MGP_CASTEiJ_G0017554	protein coding gene	Chr11:48885541-48926929 (+)
CBA/J	MGP_CBAJ_G0017967	protein coding gene	Chr11:53099635-53140746 (+)
DBA/2J	MGP_DBA2J_G0018074	protein coding gene	Chr11:47202426-47243982 (+)
FVB/NJ	MGP_FVBNJ_G0018068	protein coding gene	Chr11:46824864-46865907 (+)
LP/J	MGP_LPJ_G0018149	protein coding gene	Chr11:49629184-49672810 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018093	protein coding gene	Chr11:54640396-54685501 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018674	protein coding gene	Chr11:49018363-49061010 (+)
PWK/PhJ	MGP_PWKPhJ_G0017332	protein coding gene	Chr11:47600941-47641263 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017127	protein coding gene	Chr11:48708963-48749887 (+)
WSB/EiJ	MGP_WSBEiJ_G0017607	protein coding gene	Chr11:48658860-48700666 (+)

Human Ortholog

TBC1D9B, TBC1 domain family member 9B

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBC1D9B, TBC1 domain family member 9B
Synonyms

GRAMD9B
Links

HGNC:29097

NCBI Gene ID: 23061

UniProt: Q66K14
Chr Location

5q35.3; chr5:179862066-179907897 (-) GRCh38

MGI Vertebrate Homology

Tbc1d9b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TBC1D9B
Gene Tree

Tbc1d9b

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Genomic Mutations

1 involving Tbc1d9b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbc1d9b

less

All Sequences

161
RefSeq

17
UniProt

1
CCDS

CCDS36146.1, CCDS70175.1

Ensembl

ENSMUSG00000036644 (Evidence)
NCBI Gene

76795

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036644	Ensembl Gene Model \| MGI Sequence Detail	41390	C57BL/6J	± kb
transcript	ENSMUST00000101270	Ensembl \| MGI Sequence Detail	5213	Not Applicable
polypeptide	ENSMUSP00000098828	Ensembl \| MGI Sequence Detail	1263	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000016124 TBC1 domain family member 9B

(term hierarchy)
InterPro Domains

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR004182 GRAM domain

IPR011993 PH-like domain superfamily

IPR000195 Rab-GAP-TBC domain

IPR035969 Rab-GAP-TBC domain superfamily

IPR036014 TCB1D9/TCB1D9B, PH-GRAM domain 1

IPR036017 TCB1D9/TCB1D9B, PH-GRAM domain 2
GlyGen

Q5SVR0 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

less

All nucleic 14

cDNA 14

Microarray probesets 5

less

MGI:2144393

Summaries

All 35

Gene Ontology 5

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tbc1d9b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101213	Chr11:50021840-50021878 (+)	-364 bp
Tssr101214	Chr11:50022144-50022162 (+)	-70 bp
Tssr101215	Chr11:50022169-50022253 (+)	-12 bp
Tssr3486	Chr11:50022255-50022273 (+)	41 bp
Tssr101216	Chr11:50022829-50022856 (+)	620 bp
Tssr101217	Chr11:50025226-50025248 (+)	3,014 bp
Tssr101218	Chr11:50038742-50038744 (+)	16,520 bp
Tssr101219	Chr11:50051077-50051081 (+)	28,856 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24