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Mtif2 Gene Detail
Summary
  • Symbol
    Mtif2
  • Name
    mitochondrial translational initiation factor 2
  • Synonyms
    2310038D14Rik, 2410112O06Rik, IF-2mt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924034
    NCBI Gene: 76784
  • Gene Overview
    MyGene.info: MTIF2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:29526408-29545279 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 16.77 cM, cytoband A4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924034
protein coding gene Chr11:29526379-29545452 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018108
protein coding gene Chr11:27535027-27561153 (+)
A/J MGP_AJ_G0018080
protein coding gene Chr11:26519296-26538711 (+)
AKR/J MGP_AKRJ_G0018045
protein coding gene Chr11:27382227-27404112 (+)
BALB/cJ MGP_BALBcJ_G0018048
protein coding gene Chr11:26723176-26742259 (+)
C3H/HeJ MGP_C3HHeJ_G0017862
protein coding gene Chr11:27298992-27318249 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018501
protein coding gene Chr11:28476862-28495758 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016158
protein coding gene Chr11:25159658-25177446 (+)
CAST/EiJ MGP_CASTEiJ_G0017424
protein coding gene Chr11:27353625-27373275 (+)
CBA/J MGP_CBAJ_G0017836
protein coding gene Chr11:29821079-29844122 (+)
DBA/2J MGP_DBA2J_G0017946
protein coding gene Chr11:26379373-26398410 (+)
FVB/NJ MGP_FVBNJ_G0017938
protein coding gene Chr11:26179198-26198866 (+)
LP/J MGP_LPJ_G0018018
protein coding gene Chr11:27790460-27810416 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017964
protein coding gene Chr11:30912646-30932124 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018541
protein coding gene Chr11:27478801-27500423 (+)
PWK/PhJ MGP_PWKPhJ_G0017206
protein coding gene Chr11:26466878-26486317 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017001
protein coding gene Chr11:27168255-27197614 (+)
WSB/EiJ MGP_WSBEiJ_G0017477
protein coding gene Chr11:27183795-27208529 (+)



Homology
more
  • Human Ortholog
    MTIF2, mitochondrial translational initiation factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MTIF2, mitochondrial translational initiation factor 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4528
    neXtProt AC: NX_P46199
    UniProt: P46199

  • Chr Location
    2p16.1; chr2:55235583-55269311 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020459 Ensembl Gene Model | MGI Sequence Detail 18872 C57BL/6J ±  kb
transcript ENSMUST00000093239 Ensembl | MGI Sequence Detail 2741 Not Applicable  
polypeptide ENSMUSP00000090926 Ensembl | MGI Sequence Detail 727 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010727 translation initiation factor IF-2, mitochondrial
  • PDB
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005225 Small GTP-binding protein domain
    IPR000795 Transcription factor, GTP-binding domain
    IPR000178 Translation initiation factor aIF-2, bacterial-like
    IPR015760 Translation initiation factor IF- 2
    IPR023115 Translation initiation factor IF- 2, domain 3
    IPR036925 Translation initiation factor IF-2, domain 3 superfamily
    IPR009000 Translation protein, beta-barrel domain superfamily
Molecular
Reagents
less
  • All nucleic 57
    cDNA 55
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1925745
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory