Slc10a7 MGI Mouse Gene Detail - MGI:1924025 - solute carrier family 10 (sodium/bile acid cotransporter family), member 7

Symbol

Slc10a7
Name

solute carrier family 10 (sodium/bile acid cotransporter family), member 7
Synonyms

2410193C02Rik

Feature Type

protein coding gene
IDs

MGI:1924025
NCBI Gene: 76775
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:79235975-79460632 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 37.04 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

6831 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924025	protein coding gene	Chr8:79235957-79460641 (+)
129S1/SvImJ	ENSMUSG00200022998	protein coding gene	Chr8:73593577-73819559 (+)
A/J	ENSMUSG00195017452	protein coding gene	Chr8:73944596-74170585 (+)
AKR/J	ENSMUSG00220021354	protein coding gene	Chr8:74036381-74262385 (+)
BALB/cJ	ENSMUSG00180016567	protein coding gene	Chr8:73795719-74021705 (+)
C3H/HeJ	ENSMUSG00175010963	protein coding gene	Chr8:73866957-74092790 (+)
C57BL/6NJ	ENSMUSG00215016090	protein coding gene	Chr8:73511351-73737340 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031244	protein coding gene	Chr8:70066905-70298491 (+)
CAST/EiJ	ENSTCUG00005035426	protein coding gene	Chr8:73449387-73669432 (+)
CBA/J	ENSMUSG00210020251	protein coding gene	Chr8:73820859-74046850 (+)
DBA/2J	ENSMUSG00185010726	protein coding gene	Chr8:79976176-80202162 (+)
FVB/NJ	ENSMUSG00205019475	protein coding gene	Chr8:72966581-73193250 (+)
JF1/MsJ	ENSUMUG00000028729	protein coding gene	Chr8:82321246-82540155 (+)
LP/J	ENSMUSG00230028084	protein coding gene	Chr8:83594598-83820566 (+)
NOD/ShiLtJ	ENSMUSG00190022306	protein coding gene	Chr8:73882411-74107396 (+)
NZO/HlLtJ	ENSMUSG00225022842	protein coding gene	Chr8:86969323-87194280 (+)
PWK/PhJ	ENSLUMG00010028511	protein coding gene	Chr8:73720750-73947315 (+)
SPRET/EiJ	ENSMSPG00010021660	protein coding gene	Chr8:75468985-75690656 (+)
WSB/EiJ	ENSIUOG00005014671	protein coding gene	Chr8:74643934-74869980 (+)

Human Ortholog

SLC10A7, solute carrier family 10 member 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC10A7, solute carrier family 10 member 7
Synonyms

C4orf13, P7, SSASKS
Links

HGNC:23088

NCBI Gene ID: 84068

UniProt: Q0GE19
Chr Location

chr4:146253975-146522372 (-) GRCh38

MGI Vertebrate Homology

Slc10a7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC10A7
Protein SuperFamily

UCP026166
Gene Tree

Slc10a7

Diseases

1 with Slc10a7 mouse models

Human Disease

Mouse Models

syndrome

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

41 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

78
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

73
Targeted

2
Genomic Mutations

1 involving Slc10a7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

94 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit postnatal growth retardation and skeletal dysplasia with craniofacial anomalies, shortened long bones, brachypodia, growth plate disorganization, and tooth enamel defects.

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All GO Annotations

30
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

633
Tissues

30
cDNA Data

39
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc10a7

ZFIN slc10a7

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All Sequences

90
RefSeq

29
UniProt

4
CCDS

CCDS40395.1, CCDS85567.1, CCDS85568.1

Ensembl

ENSMUSG00000031684 (Evidence)
NCBI Gene

76775

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031684	Ensembl Gene Model \| MGI Sequence Detail	224658	C57BL/6J	± kb
transcript	ENSMUST00000034111	Ensembl \| MGI Sequence Detail	3595	Not Applicable
polypeptide	ENSMUSP00000034111	Ensembl \| MGI Sequence Detail	340	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014923 sodium/bile acid cotransporter 7

(term hierarchy)
InterPro Domains

IPR016833 Putative sodium bile acid cotransporter

IPR038770 Sodium/solute symporter superfamily

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All nucleic 41

cDNA 39

Primer pair 1

Other 1

Microarray probesets 5

Summaries

All 44

Developmental Gene Expression 3

Diseases 1

Gene Ontology 8

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:298768 Laugel-Haushalter V, et al., A New SLC10A7 Homozygous Missense Mutation Responsible for a Milder Phenotype of Skeletal Dysplasia With Amelogenesis Imperfecta. Front Genet. 2019;10:504

TSS for Slc10a7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78115	Chr8:79235250-79235261 (+)	-719 bp
Tssr78116	Chr8:79235948-79236028 (+)	13 bp
Tssr78117	Chr8:79236035-79236046 (+)	66 bp
Tssr78118	Chr8:79236051-79236065 (+)	83 bp
Tssr78119	Chr8:79316028-79316030 (+)	80,054 bp
Tssr78120	Chr8:79460160-79460163 (+)	224,187 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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