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Alpi
Gene Detail
 Symbol
Name
ID
Alpi
alkaline phosphatase, intestinal
MGI:1924018
Synonyms 2010001C14Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
44.05 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:87098002-87101606 bp, - strand
From VEGA annotation of GRCm38

  3605 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:122414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee

Gene Tree: Alpi

Human
homologs
Human Homolog ALPP, alkaline phosphatase, placental
NCBI Gene ID 250
neXtProt AC  NX_P05187
Human Synonyms  ALP, PALP, PLAP, PLAP-1
Human Chr (Location)  2q37; chr2:232378534-232382889 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Alpi interacts with 75 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cellular response to BMP stimulus, dephosphorylation, ...
Component cell surface, external side of plasma membrane
Function alkaline phosphatase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(17) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000048153 (Evidence)
Ensembl Gene ModelENSMUSG00000079440 (Evidence)
Entrez Gene76768 (Evidence)
UniGene58068
DFCITC1604210
DoTSDT.489307
NIA Mouse Gene IndexU021565
EC3.1.3.1
Consensus CDS ProjectCCDS35650.1
International Mouse Knockout Project StatusAlpi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048153 VEGA Gene Model | MGI Sequence Detail 3605 C57BL/6J ±  kb
transcript OTTMUST00000123667 VEGA | MGI Sequence Detail 2337 Not Applicable 
polypeptide OTTMUSP00000067466 VEGA | MGI Sequence Detail 554 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(28 from dbSNP Build 137)    SNPs within 2kb including multiple locations(30)
Protein-related
information
ResourceIDDescription
InterPro IPR001952 Alkaline phosphatase
InterPro IPR018299 Alkaline phosphatase, active site
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
References (Earliest) J:65433 Xie Q, et al., The two isozymes of rat intestinal alkaline phosphatase are products of two distinct genes. Physiol Genomics. 2000 Jun 29;3(1):1-8
(Latest) J:171138 Hu R, et al., A Runx2/miR-3960/miR-2861 Regulatory Feedback Loop during Mouse Osteoblast Differentiation. J Biol Chem. 2011 Apr 8;286(14):12328-39
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory