Alpi
Gene Detail

Symbol

Name
ID

Alpi
alkaline phosphatase, intestinal
MGI:1924018

Synonyms

2010001C14Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1
44.05 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:87098002-87101606 bp, - strand From VEGA annotation of GRCm38   3605 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:122414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee

Gene Tree: Alpi

Human
homologs

Human Homolog		ALPP, alkaline phosphatase, placental
NCBI Gene ID		250
neXtProt AC		NX_P05187
Human Synonyms		ALP, PALP, PLAP, PLAP-1
Human Chr (Location)		2q37; chr2:232378534-232382889 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(2) : Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Alpi interacts with 75 markers (Mir1b, Mir9-1, Mir9-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (11 annotations)

Process	cellular response to BMP stimulus, dephosphorylation, ...
Component	cell surface, external side of plasma membrane
Function	alkaline phosphatase activity, magnesium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	94

cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(19) cDNA(17) Primer pair(1) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000048153 (Evidence)
Ensembl Gene Model	ENSMUSG00000079440 (Evidence)
Entrez Gene	76768 (Evidence)
UniGene	58068
DFCI	TC1604210
DoTS	DT.489307
NIA Mouse Gene Index	U021565
EC	3.1.3.1
Consensus CDS Project	CCDS35650.1
International Mouse Knockout Project Status	Alpi

Sequences

Length	Strain/Species
genomic	OTTMUSG00000048153	VEGA Gene Model | MGI Sequence Detail	3605	C57BL/6J
transcript	OTTMUST00000123667	VEGA | MGI Sequence Detail	2337	Not Applicable
polypeptide	OTTMUSP00000067466	VEGA | MGI Sequence Detail	554	Not Applicable

All sequences(22) RefSeq(2) UniProt(4)

Polymorphisms

SNPs within 2kb(28 from dbSNP Build 137)    SNPs within 2kb including multiple locations(30)

Protein-related
information

Resource	ID	Description
InterPro	IPR001952	Alkaline phosphatase
InterPro	IPR018299	Alkaline phosphatase, active site
InterPro	IPR017849	Alkaline phosphatase-like, alpha/beta/alpha
InterPro	IPR017850	Alkaline-phosphatase-like, core domain

References

(Earliest) J:65433 Xie Q, et al., The two isozymes of rat intestinal alkaline phosphatase are products of two distinct genes. Physiol Genomics. 2000 Jun 29;3(1):1-8
(Latest) J:212415 Kinzel B, et al., Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Dev Biol. 2014 Jun 15;390(2):181-90
All references(31)