Alpi MGI Mouse Gene Detail - MGI:1924018 - alkaline phosphatase, intestinal

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Alpi Gene Detail

Symbol

Alpi
Name

alkaline phosphatase, intestinal
Synonyms

2010001C14Rik

Feature Type

protein coding gene
IDs

MGI:1924018
NCBI Gene: 76768
Alliance

gene page
Transcription Start Sites

21 TSS

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Sequence Map

Chr1:87025724-87029328 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 44.05 cM, cytoband C5
Mapping Data

3 experiments

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SNPs within 2kb

144 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1924018	protein coding gene	Chr1:87025724-87029328 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016255	protein coding gene	Chr1:88430338-88433942 (-)
A/J	MGP_AJ_G0016236	protein coding gene	Chr1:85129935-85133539 (-)
AKR/J	MGP_AKRJ_G0016197	protein coding gene	Chr1:87643376-87646980 (-)
BALB/cJ	MGP_BALBcJ_G0016193	protein coding gene	Chr1:85249838-85253442 (-)
C3H/HeJ	MGP_C3HHeJ_G0016021	protein coding gene	Chr1:87903528-87907132 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016649	protein coding gene	Chr1:91780390-91783994 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014371	protein coding gene	Chr1:79583356-79586980 (-)
CAST/EiJ	MGP_CASTEiJ_G0015606	protein coding gene	Chr1:87106400-87110034 (-)
CBA/J	MGP_CBAJ_G0015997	protein coding gene	Chr1:94640704-94644308 (-)
DBA/2J	MGP_DBA2J_G0016100	protein coding gene	Chr1:84433820-84437424 (-)
FVB/NJ	MGP_FVBNJ_G0016099	protein coding gene	Chr1:83496686-83500290 (-)
LP/J	MGP_LPJ_G0016171	protein coding gene	Chr1:89499562-89503166 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016125	protein coding gene	Chr1:97929405-97933009 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016692	protein coding gene	Chr1:87745145-87748749 (-)
PWK/PhJ	MGP_PWKPhJ_G0015393	protein coding gene	Chr1:83731135-83734769 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015173	protein coding gene	Chr1:86672612-86676246 (-)
WSB/EiJ	MGP_WSBEiJ_G0015670	protein coding gene	Chr1:87412721-87416325 (-)

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Human Ortholog

ALPG, alkaline phosphatase, germ cell

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALPG, alkaline phosphatase, germ cell
Synonyms

ALPPL, ALPPL2, GCAP
Links

HGNC:441

NCBI Gene ID: 251

UniProt: P10696
Chr Location

2q37.1; chr2:232406844-232410714 (+) GRCh38

Human Ortholog

ALPI, alkaline phosphatase, intestinal
Synonyms

IAP
Links

HGNC:437

NCBI Gene ID: 248

UniProt: P09923
Chr Location

2q37.1; chr2:232456125-232460753 (+) GRCh38

Human Ortholog

ALPP, alkaline phosphatase, placental
Synonyms

ALP, ALPI, IAP, PALP, PLAP, PLAP-1
Links

HGNC:439

NCBI Gene ID: 250

UniProt: P05187
Chr Location

2q37.1; chr2:232378724-232382889 (+) GRCh38

MGI Vertebrate Homology

Alpi stringent orthology
3 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ALPG, ALPI, ALPP
Gene Tree

Alpi

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Diseases

1 with human ALPI associations

				Human Disease	Mouse Models
				inflammatory bowel disease IDs inflammatory bowel disease DOID:0050589 EFO:0003767 KEGG:05321 MESH:D015212 NCI:C3138 OMIM:PS266600 UMLS_CUI:C0021390

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Alpi
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

816
Tissues

104
cDNA Data

19
Literature Summary

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ALPIL

Xenbase alpi, alpi.2

ZFIN alpi.1, alpi.2

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS35650.1

Ensembl

ENSMUSG00000079440 (Evidence)
NCBI Gene

76768

Representative Sequences				Length	Strain/Species	Flank
	genomic	76768	NCBI Gene Model \| MGI Sequence Detail	3605	C57BL/6J	± kb
	transcript	NM_001081082	RefSeq \| MGI Sequence Detail	2337	C57BL/6
	polypeptide	NP_001074551	RefSeq \| MGI Sequence Detail	554	C57BL/6

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UniProt

2 Sequences
EC

3.1.3.1
InterPro Domains

IPR001952 Alkaline phosphatase

IPR018299 Alkaline phosphatase, active site

IPR017850 Alkaline-phosphatase-like, core domain superfamily

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All nucleic 23

cDNA 19

Primer pair 4

Microarray probesets 3

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Summaries

All 46

Developmental Gene Expression 10

Gene Ontology 6

Phenotypes 8
Earliest

J:336433 Eaton RH, et al., Organic pyrophosphates as substrates for human alkaline phosphatases. Biochem J. 1967 Dec;105(3):1307-12
Latest

J:358533 Song HJ, et al., Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency. Int J Mol Sci. 2024 Sep 2;25(17)

TSS for Alpi:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12837	Chr1:87029958-87029974 (-)	-638 bp
Tssr12836	Chr1:87029437-87029441 (-)	-111 bp
Tssr12835	Chr1:87029352-87029358 (-)	-27 bp
Tssr12834	Chr1:87029312-87029339 (-)	2 bp
Tssr12833	Chr1:87029283-87029288 (-)	42 bp
Tssr12832	Chr1:87028320-87028334 (-)	1,001 bp
Tssr12831	Chr1:87028301-87028314 (-)	1,020 bp
Tssr12830	Chr1:87028284-87028293 (-)	1,039 bp
Tssr12829	Chr1:87028038-87028076 (-)	1,271 bp
Tssr12828	Chr1:87027903-87027914 (-)	1,419 bp
Tssr12827	Chr1:87027456-87027469 (-)	1,865 bp
Tssr12826	Chr1:87027271-87027283 (-)	2,051 bp
Tssr12825	Chr1:87027247-87027257 (-)	2,076 bp
Tssr12824	Chr1:87027167-87027176 (-)	2,156 bp
Tssr12823	Chr1:87027141-87027150 (-)	2,182 bp
Tssr12822	Chr1:87026857-87026866 (-)	2,466 bp
Tssr12821	Chr1:87026599-87026626 (-)	2,715 bp
Tssr12820	Chr1:87026523-87026533 (-)	2,800 bp
Tssr12819	Chr1:87026281-87026321 (-)	3,027 bp
Tssr12818	Chr1:87026261-87026280 (-)	3,057 bp
Tssr12817	Chr1:87025820-87025838 (-)	3,499 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24