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Alpi Gene Detail
Summary
  • Symbol
    Alpi
  • Name
    alkaline phosphatase, intestinal
  • Synonyms
    2010001C14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924018
    NCBI Gene: 76768
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:87098002-87101606 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      3605 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.05 cM, cytoband C5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ALPI, alkaline phosphatase, intestinal
  • Vertebrate Orthologs
    4
  • Human Ortholog
    ALPI, alkaline phosphatase, intestinal
    Orthology source: HGNC
  • Synonyms
    IAP
  • Links
    NCBI Gene ID: 248
    neXtProt AC: NX_P09923
    UniProt: P09923

  • Chr Location
    2q37.1; chr2:232456112-232460745 (+)  GRCh38.p7
  • Human Ortholog
    ALPP, alkaline phosphatase, placental
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALP, PALP, PLAP, PLAP-1
  • Links
    NCBI Gene ID: 250
    neXtProt AC: NX_P05187
    UniProt: P05187

  • Chr Location
    2q37.1; chr2:232378534-232382889 (+)  GRCh38.p7
  • Human Ortholog
    ALPPL2, alkaline phosphatase, placental like 2
    Orthology source: HGNC
  • Synonyms
    ALPG, ALPPL, GCAP
  • Links
    NCBI Gene ID: 251
    neXtProt AC: NX_P10696
    UniProt: P10696

  • Chr Location
    2q37.1; chr2:232406842-232410714 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    94
  • Tissues
    94
  • cDNA Data
    17
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048153 VEGA Gene Model | MGI Sequence Detail 3605 C57BL/6J ±  kb
transcript OTTMUST00000123667 VEGA | MGI Sequence Detail 2337 Not Applicable  
polypeptide OTTMUSP00000067466 VEGA | MGI Sequence Detail 554 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    27 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    3.1.3.1
  • InterPro Domains
    IPR001952 Alkaline phosphatase
    IPR018299 Alkaline phosphatase, active site
    IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
    IPR017850 Alkaline-phosphatase-like, core domain superfamily
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:240472 Kumar N, et al., A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development. 2016 Oct 15;143(20):3711-3722
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory