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Alpi
Gene Detail
Symbol

Name
ID
Alpi
alkaline phosphatase, intestinal
MGI:1924018
Synonyms
2010001C14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
44.05 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:87098002-87101606 bp, - strand
From VEGA annotation of GRCm38

  3605 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:122414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee

HCOP human homology predictions: ALPP
Gene Tree: Alpi

Human
homologs
ALPP, alkaline phosphatase, placental
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 250
neXtProt AC: NX_P05187

Human Synonyms: ALP, PALP, PLAP, PLAP-1

Human Chr (Location): 2q37; chr2:232378534-232382889 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Alpi interacts with 74 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cellular response to BMP stimulus, dephosphorylation, ...
Component cell surface, external side of plasma membrane
Function alkaline phosphatase activity, magnesium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase alpi.1, alpi.2 ; ZFIN alpi.1, alpi.2    NEW 
Molecular
reagents
All nucleic(19) cDNA(17) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048153 (Evidence)
Ensembl Gene Model ENSMUSG00000079440 (Evidence)
Entrez Gene 76768 (Evidence)
UniGene 58068
DFCI TC1604210
DoTS DT.489307
NIA Mouse Gene Index U021565
EC 3.1.3.1
Consensus CDS Project CCDS35650.1
International Mouse Phenotyping Consortium Status Alpi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048153 VEGA Gene Model | MGI Sequence Detail 3605 C57BL/6J ±  kb
transcript OTTMUST00000123667 VEGA | MGI Sequence Detail 2337 Not Applicable 
polypeptide OTTMUSP00000067466 VEGA | MGI Sequence Detail 554 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(28 from dbSNP Build 137)    SNPs within 2kb including multiple locations(30)
Protein-related
information
ResourceIDDescription
InterPro IPR001952 Alkaline phosphatase
InterPro IPR018299 Alkaline phosphatase, active site
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212415 Kinzel B, et al., Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Dev Biol. 2014 Jun 15;390(2):181-90
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory