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Trdn
Gene Detail
Symbol

Name
ID
Trdn
triadin
MGI:1924007
Synonyms
2310045H21Rik, EG432451, triadin 1, triadin-1, triadin 2, triadin-2, triadin 3, triadin-3
Feature Type
protein coding gene
Genetic Map
Chromosome 10
18.37 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:33083483-33476709 bp, + strand
From NCBI annotation of GRCm38

  393227 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38137  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Trdn

Human
homologs
Human Homolog TRDN, triadin
NCBI Gene ID 10345
neXtProt AC  NX_Q13061
Human Synonyms  CPVT5, TDN, TRISK
Human Chr (Location)  6q22.31; chr6:123216339-123637283 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TRDN
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit a loss of transverse orientation of triads within skeletal muscle cells.
 
Interactions
Trdn interacts with 304 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cellular calcium ion homeostasis, cytoplasmic microtubule organization, ...
Component calcium channel complex, cell, ...
Function protein binding, receptor binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (33)    Tissues (31)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
RT-PCR 11
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000019787 (Evidence)
Entrez Gene76757 (Evidence)
UniGene338508
DFCITC1708202, TC1617079, TC1586176
DoTSDT.40134508, DT.526285, DT.40167465, DT.97391399, DT.101400677
NIA Mouse Gene IndexU011389
Consensus CDS ProjectCCDS48532.1
International Mouse Knockout Project StatusTrdn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 76757 NCBI Gene Model | MGI Sequence Detail 393227 C57BL/6J ±  kb
transcript NM_029726 RefSeq | MGI Sequence Detail 4514 Not Specified 
polypeptide E9Q9K5 UniProt | EBI | MGI Sequence Detail 693 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(1382 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1384)
Protein-related
information
ResourceIDDescription
InterPro IPR007943 Aspartyl beta-hydroxylase/Triadin domain
InterPro IPR010798 Triadin
Protein Ontology PR:000016623 triadin
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213081 Singh VP, et al., Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein. J Am Heart Assoc. 2013 Oct;2(5):e000460
All references(45)
Other
accession IDs
MGI:3646337

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory