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Trdn
Gene Detail
Symbol

Name
ID
Trdn
triadin
MGI:1924007
Synonyms
2310045H21Rik, EG432451, triadin 1, triadin-1, triadin 2, triadin-2, triadin 3, triadin-3
Feature Type
protein coding gene
Genetic Map
Chromosome 10
18.37 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:33083483-33476709 bp, + strand
From NCBI annotation of GRCm38

  393227 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38137  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TRDN
Gene Tree: Trdn

Human
homologs
TRDN, triadin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10345
neXtProt AC: NX_Q13061

Human Synonyms: CPVT5, TDN, TRISK

Human Chr (Location): 6q22.31; chr6:123216339-123637283 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TRDN

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit a loss of transverse orientation of triads within skeletal muscle cells.
 
Interactions
Trdn interacts with 303 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cellular calcium ion homeostasis, cytoplasmic microtubule organization, ...
Component calcium channel complex, cell, ...
Function protein binding, receptor binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (31)    Tissues (29)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 11
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trdn    NEW 
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(9)
Other database
links
Ensembl Gene Model ENSMUSG00000019787 (Evidence)
Entrez Gene 76757 (Evidence)
UniGene 338508
DFCI TC1708202, TC1617079, TC1586176
DoTS DT.40134508, DT.101400677, DT.97391399, DT.526285, DT.40167465
NIA Mouse Gene Index U011389
Consensus CDS Project CCDS48532.1
International Mouse Phenotyping Consortium Status Trdn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 76757 NCBI Gene Model | MGI Sequence Detail 393227 C57BL/6J ±  kb
transcript NM_029726 RefSeq | MGI Sequence Detail 4514 Not Specified 
polypeptide E9Q9K5 UniProt | EBI | MGI Sequence Detail 693 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(1382 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1384)
Protein-related
information
ResourceIDDescription
InterPro IPR007943 Aspartyl beta-hydroxylase/Triadin domain
InterPro IPR010798 Triadin
Protein Ontology PR:000016623 triadin
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210497 Rossi D, et al., Distinct regions of triadin are required for targeting and retention at the junctional domain of the sarcoplasmic reticulum. Biochem J. 2014 Mar 1;458(2):407-17
All references(44)
Other
accession IDs
MGI:3646337

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory