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Gje1 Gene Detail
Summary
  • Symbol
    Gje1
  • Name
    gap junction protein, epsilon 1
  • Synonyms
    AEY12, connexin 23, Cx23, D230044M03Rik, Gjf1, Gsfaey12
Location &
Maps
more
  • Sequence Map
    Chr10:14591367-14593958 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 5.50 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923993
 protein coding gene Chr10:14591365-14593958 (-)
129S1/SvImJ ENSMUSG00200009188
 protein coding gene Chr10:11614052-11616643 (-)
A/J ENSMUSG00195006759
 protein coding gene Chr10:11527311-11529902 (-)
AKR/J ENSMUSG00220013413
 protein coding gene Chr2:17417418-17420009 (-)
BALB/cJ ENSMUSG00180014509
 protein coding gene Chr10:11684236-11686827 (-)
C3H/HeJ ENSMUSG00175019348
 protein coding gene Chr10:11680395-11682986 (-)
C57BL/6NJ ENSMUSG00215003379
 protein coding gene Chr10:11546831-11549422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015133
 protein coding gene Chr10:10951273-10953860 (-)
CAST/EiJ ENSTCUG00005029067
 protein coding gene Chr10:11529213-11531802 (-)
CBA/J ENSMUSG00210015472
 protein coding gene Chr10:11630062-11632653 (-)
DBA/2J ENSMUSG00185007171
 protein coding gene Chr10:11670296-11672884 (-)
FVB/NJ ENSMUSG00205014690
 protein coding gene Chr10:11724245-11726836 (-)
JF1/MsJ ENSUMUG00000012132
 protein coding gene Chr10:11712748-11715336 (-)
LP/J ENSMUSG00230015186
 protein coding gene Chr10:13283331-13285922 (-)
NOD/ShiLtJ ENSMUSG00190010777
 protein coding gene Chr10:11662173-11664764 (-)
NZO/HlLtJ ENSMUSG00225015992
 protein coding gene Chr10:17799922-17802512 (-)
PWK/PhJ ENSLUMG00010015182
 protein coding gene Chr10:11437274-11439859 (-)
SPRET/EiJ ENSMSPG00010010176
 protein coding gene Chr10:11888097-11890697 (-)
WSB/EiJ ENSIUOG00005021646
 protein coding gene Chr10:11265842-11268433 (-)



Homology
more
  • Human Ortholog
    GJE1, gap junction protein epsilon 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GJE1, gap junction protein epsilon 1
  • Synonyms
    CX23
  • Links
    NCBI Gene ID: 100126572
    UniProt: A6NN92

  • Chr Location
    6q24.1; chr6:142132925-142135358 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with a mutation in this gene have small eyes. Eye/lens development arrests at the lens vesicle stage, and no primary lens fibers form.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    633
  • Tissues
    24
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019867 Ensembl Gene Model | MGI Sequence Detail 2592 C57BL/6J ±  kb
    transcript ENSMUST00000020016 Ensembl | MGI Sequence Detail 1480 Not Applicable  
    polypeptide ENSMUSP00000020016 Ensembl | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3529956
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory