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Snx27 Gene Detail
Summary
  • Symbol
    Snx27
  • Name
    sorting nexin family member 27
  • Synonyms
    5730552M22Rik, ESTM47, mKIAA0488
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923992
    NCBI Gene: 76742
  • Gene Overview
    MyGene.info: SNX27
Location & Maps
more
  • Sequence Map
    Chr3:94497544-94582716 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      85173 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SNX27, sorting nexin family member 27
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SNX27, sorting nexin family member 27
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MRT1, MY014
  • Links
    NCBI Gene ID: 81609
    neXtProt AC: NX_Q96L92

  • Chr Location
    1q21.3; chr1:151611984-151699083 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Snx27
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit prenatal and postnatal lethality, decreased organ size, slow postnatal weight gain, and decreased endocytosis of Grin2c.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019563 VEGA Gene Model | MGI Sequence Detail 85173 C57BL/6J ±  kb
transcript OTTMUST00000046711 VEGA | MGI Sequence Detail 3531 Not Applicable  
polypeptide OTTMUSP00000021102 VEGA | MGI Sequence Detail 539 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    319 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1334427
References
more
  • Summaries
    All 42
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
  • Latest
    J:214337 Munoz MB, et al., Sorting nexin 27 regulation of G protein-gated inwardly rectifying K(+) channels attenuates in vivo cocaine response. Neuron. 2014 May 7;82(3):659-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory