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Snx27 Gene Detail
Summary
  • Symbol
    Snx27
  • Name
    sorting nexin family member 27
  • Synonyms
    5730552M22Rik, ESTM47, mKIAA0488
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923992
    NCBI Gene: 76742
  • Gene Overview
    MyGene.info: SNX27
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:94497544-94582716 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    319 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923992
protein coding gene Chr3:94497542-94582716 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027554
protein coding gene Chr3:95076515-95162376 (-)
A/J MGP_AJ_G0027513
protein coding gene Chr3:92185133-92264781 (-)
AKR/J MGP_AKRJ_G0027481
protein coding gene Chr3:94280090-94362673 (-)
BALB/cJ MGP_BALBcJ_G0027524
protein coding gene Chr3:91894937-91974055 (-)
C3H/HeJ MGP_C3HHeJ_G0027260
protein coding gene Chr3:94585048-94667574 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027973
protein coding gene Chr3:98662563-98757159 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025315
protein coding gene Chr3:88675597-88756302 (-)
CAST/EiJ MGP_CASTEiJ_G0026708
protein coding gene Chr3:93922432-94007406 (-)
CBA/J MGP_CBAJ_G0027236
protein coding gene Chr3:102163430-102250576 (-)
DBA/2J MGP_DBA2J_G0027375
protein coding gene Chr3:91448976-91527728 (-)
FVB/NJ MGP_FVBNJ_G0027345
protein coding gene Chr3:89547356-89624922 (-)
LP/J MGP_LPJ_G0027483
protein coding gene Chr3:96384384-96466218 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027372
protein coding gene Chr3:108394457-108477787 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028027
protein coding gene Chr3:93955402-94042695 (-)
PWK/PhJ MGP_PWKPhJ_G0026436
protein coding gene Chr3:91337793-91418094 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026257
protein coding gene Chr3:92298784-92373469 (-)
WSB/EiJ MGP_WSBEiJ_G0026791
protein coding gene Chr3:94309193-94394597 (-)



Homology
more
  • Human Ortholog
    SNX27, sorting nexin family member 27
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SNX27, sorting nexin family member 27
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRT1, MY014
  • Links
    NCBI Gene ID: 81609
    neXtProt AC: NX_Q96L92
    UniProt: Q96L92

  • Chr Location
    1q21.3; chr1:151612027-151699083 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit prenatal and postnatal lethality, decreased organ size, slow postnatal weight gain, and decreased endocytosis of Grin2c.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028136 Ensembl Gene Model | MGI Sequence Detail 85173 C57BL/6J ±  kb
    transcript ENSMUST00000107283 Ensembl | MGI Sequence Detail 3531 Not Applicable  
    polypeptide ENSMUSP00000102904 Ensembl | MGI Sequence Detail 539 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1334427
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:255770 Tello-Lafoz M, et al., SNX27 links DGKzeta to the control of transcriptional and metabolic programs in T lymphocytes. Sci Rep. 2017 Nov 27;7(1):16361

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory