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Paf1 Gene Detail
Summary
  • Symbol
    Paf1
  • Name
    Paf1, RNA polymerase II complex component
  • Synonyms
    5730511K23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923988
    NCBI Gene: 54624
Location & Maps
more
  • Sequence Map
    Chr7:28392951-28399388 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6438 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PAF1, PAF1 homolog, Paf1/RNA polymerase II complex component
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PAF1, PAF1 homolog, Paf1/RNA polymerase II complex component
    Orthology source: HGNC, HomoloGene
  • Synonyms
    F23149_1, PD2
  • Links
    NCBI Gene ID: 54623
    neXtProt AC: NX_Q8N7H5

  • Chr Location
    19q13.1; chr19:39385629-39391195 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    1
  • Gene trapped
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023577 VEGA Gene Model | MGI Sequence Detail 6438 C57BL/6J ±  kb
transcript OTTMUST00000057537 VEGA | MGI Sequence Detail 2003 Not Applicable  
polypeptide OTTMUSP00000027761 VEGA | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    22 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012226 RNA polymerase II-associated factor 1
  • InterPro Domains
    IPR007133 RNA polymerase II associated factor Paf1
Molecular
Reagents
less
  • All nucleic 114
    cDNA 113
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141848
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:201693 Zhang C, et al., The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain. Neuron. 2013 Jun 19;78(6):986-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory