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Ckmt2
Gene Detail
 Symbol
Name
ID
Ckmt2
creatine kinase, mitochondrial 2
MGI:1923972
Synonyms 2300008A19Rik, ScCKmit
Feature Type protein coding gene
Genetic Map
Chromosome 13
47.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:91853387-91876885 bp, - strand
From VEGA annotation of GRCm38

  23499 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68206  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: creatine kinase
Gene Tree: Ckmt2

Human
homologs
Human Homolog CKMT2, creatine kinase, mitochondrial 2 (sarcomeric)
NCBI Gene ID 1160
neXtProt AC  NX_P17540
Human Synonyms  SMTCK
Human Chr (Location)  5q13.3; chr5:81232982-81266398 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
The hearts of mice homozygous for disruptions of this gene have hypertrophic and dilated left ventricles exhibit functional abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process phosphocreatine metabolic process, phosphorylation
Component membrane, mitochondrial inner membrane, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (98)    Tissues (97)    Images (2)
Theiler Stages: 21, 22, 23, 24
Assay TypeResults
RNA in situ 94
RT-PCR 4
cDNA source data(47)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(49) cDNA(47) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029571 (Evidence)
Ensembl Gene ModelENSMUSG00000021622 (Evidence)
Entrez Gene76722 (Evidence)
UniGene316438
DFCITC1579058, TC1731576
DoTSDT.492687, DT.91338717
NIA Mouse Gene IndexU035018
EC2.7.3.2
Consensus CDS ProjectCCDS26679.1
International Mouse Knockout Project StatusCkmt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029571 VEGA Gene Model | MGI Sequence Detail 23499 C57BL/6J ±  kb
transcript OTTMUST00000073334 VEGA | MGI Sequence Detail 1486 Not Applicable 
polypeptide OTTMUSP00000037934 VEGA | MGI Sequence Detail 419 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(185 from dbSNP Build 137)    SNPs within 2kb including multiple locations(187)
Protein-related
information
ResourceIDDescription
InterPro IPR022415 ATP:guanido phosphotransferase active site
InterPro IPR022414 ATP:guanido phosphotransferase, catalytic domain
InterPro IPR022413 ATP:guanido phosphotransferase, N-terminal
InterPro IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
Protein Ontology PR:000005517 creatine kinase, sarcomeric mitochondrial
References (Earliest) J:76700 Steeghs K, et al., Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell. 1997 Apr 4;89(1):93-103
(Latest) J:191701 Dzeja PP, et al., Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency. J Physiol. 2011 Nov 1;589(Pt 21):5193-211
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory