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Ckmt2 Gene Detail
Summary
  • Symbol
    Ckmt2
  • Name
    creatine kinase, mitochondrial 2
  • Synonyms
    2300008A19Rik, ScCKmit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923972
    NCBI Gene: 76722
  • Gene Overview
    MyGene.info: CKMT2
Location & Maps
more
  • Sequence Map
    Chr13:91853387-91876885 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23499 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CKMT2, creatine kinase, mitochondrial 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CKMT2, creatine kinase, mitochondrial 2
    Orthology source: HomoloGene
  • Synonyms
    SMTCK
  • Links
    NCBI Gene ID: 1160
    neXtProt AC: NX_P17540

  • Chr Location
    5q13.3; chr5:81233320-81266398 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Ckmt2
  • Incidental Mutations
The hearts of mice homozygous for disruptions of this gene have hypertrophic and dilated left ventricles exhibit functional abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029571 VEGA Gene Model | MGI Sequence Detail 23499 C57BL/6J ±  kb
transcript OTTMUST00000073334 VEGA | MGI Sequence Detail 1486 Not Applicable  
polypeptide OTTMUSP00000037934 VEGA | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    182 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005517 creatine kinase, sarcomeric mitochondrial
  • EC
  • InterPro Domains
    IPR000749 ATP:guanido phosphotransferase
    IPR022415 ATP:guanido phosphotransferase active site
    IPR022414 ATP:guanido phosphotransferase, catalytic domain
    IPR022413 ATP:guanido phosphotransferase, N-terminal
    IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
Molecular
Reagents
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  • All nucleic 49
    cDNA 47
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 51
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 28
  • Earliest
    J:76700 Steeghs K, et al., Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell. 1997 Apr 4;89(1):93-103
  • Latest
    J:214478 Tanimura A, et al., Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation. PLoS One. 2014;9(2):e89916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory