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Ckmt2 Gene Detail
Summary
  • Symbol
    Ckmt2
  • Name
    creatine kinase, mitochondrial 2
  • Synonyms
    2300008A19Rik, ScCKmit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923972
    NCBI Gene: 76722
  • Gene Overview
    MyGene.info: CKMT2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:91853387-91876885 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 47.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923972
protein coding gene Chr13:91853387-91876923 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020810
protein coding gene Chr13:93143302-93167402 (-)
A/J MGP_AJ_G0020764
protein coding gene Chr13:89700119-89724563 (-)
AKR/J MGP_AKRJ_G0020737
protein coding gene Chr13:92420836-92444934 (-)
BALB/cJ MGP_BALBcJ_G0020760
protein coding gene Chr13:90340691-90366216 (-)
C3H/HeJ MGP_C3HHeJ_G0020554
protein coding gene Chr13:92119912-92144500 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021197
protein coding gene Chr13:95997978-96022659 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018765
protein coding gene Chr13:85648160-85671425 (-)
CAST/EiJ MGP_CASTEiJ_G0020073
protein coding gene Chr13:91388986-91416504 (-)
CBA/J MGP_CBAJ_G0020513
protein coding gene Chr13:99802367-99828684 (-)
DBA/2J MGP_DBA2J_G0020638
protein coding gene Chr13:89457135-89480493 (-)
FVB/NJ MGP_FVBNJ_G0020618
protein coding gene Chr13:88278632-88302137 (-)
LP/J MGP_LPJ_G0020711
protein coding gene Chr13:93263789-93288142 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020647
protein coding gene Chr13:100312607-100337280 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021237
protein coding gene Chr13:91817403-91844940 (-)
PWK/PhJ MGP_PWKPhJ_G0019825
protein coding gene Chr13:88204431-88228643 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019649
protein coding gene Chr13:88086720-88109338 (-)
WSB/EiJ MGP_WSBEiJ_G0020130
protein coding gene Chr13:92302489-92326841 (-)



Homology
more
  • Human Ortholog
    CKMT2, creatine kinase, mitochondrial 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CKMT2, creatine kinase, mitochondrial 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SMTCK
  • Links
    NCBI Gene ID: 1160
    neXtProt AC: NX_P17540
    UniProt: P17540

  • Chr Location
    5q14.1; chr5:81233320-81266398 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
The hearts of mice homozygous for disruptions of this gene have hypertrophic and dilated left ventricles exhibit functional abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021622 Ensembl Gene Model | MGI Sequence Detail 23499 C57BL/6J ±  kb
    transcript ENSMUST00000022122 Ensembl | MGI Sequence Detail 1486 Not Applicable  
    polypeptide ENSMUSP00000022122 Ensembl | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005517 creatine kinase, sarcomeric mitochondrial
    • EC
    • InterPro Domains
      IPR000749 ATP:guanido phosphotransferase
      IPR022415 ATP:guanido phosphotransferase active site
      IPR022414 ATP:guanido phosphotransferase, catalytic domain
      IPR022413 ATP:guanido phosphotransferase, N-terminal
      IPR036802 ATP:guanido phosphotransferase, N-terminal domain superfamily
      IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 48
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 28
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:241230 Spitler KM, et al., Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming. Am J Physiol Heart Circ Physiol. 2017 Apr 01;312(4):H768-H780

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory