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Ckmt2 Gene Detail
Summary
  • Symbol
    Ckmt2
  • Name
    creatine kinase, mitochondrial 2
  • Synonyms
    2300008A19Rik, ScCKmit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923972
    NCBI Gene: 76722
  • Gene Overview
    MyGene.info: CKMT2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:91853387-91876885 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23499 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 47.43 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CKMT2, creatine kinase, mitochondrial 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CKMT2, creatine kinase, mitochondrial 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SMTCK
  • Links
    NCBI Gene ID: 1160
    neXtProt AC: NX_P17540
    UniProt: P17540

  • Chr Location
    5q14.1; chr5:81233320-81266398 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The hearts of mice homozygous for disruptions of this gene have hypertrophic and dilated left ventricles exhibit functional abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029571 VEGA Gene Model | MGI Sequence Detail 23499 C57BL/6J ±  kb
    transcript OTTMUST00000073334 VEGA | MGI Sequence Detail 1486 Not Applicable  
    polypeptide OTTMUSP00000037934 VEGA | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      182 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005517 creatine kinase, sarcomeric mitochondrial
    • EC
    • InterPro Domains
      IPR000749 ATP:guanido phosphotransferase
      IPR022415 ATP:guanido phosphotransferase active site
      IPR022414 ATP:guanido phosphotransferase, catalytic domain
      IPR022413 ATP:guanido phosphotransferase, N-terminal
      IPR036802 ATP:guanido phosphotransferase, N-terminal domain superfamily
      IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
    Molecular
    Reagents
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    • All nucleic 49
      cDNA 47
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 28
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:241230 Spitler KM, et al., Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming. Am J Physiol Heart Circ Physiol. 2017 Apr 01;312(4):H768-H780

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory