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Ckmt2
Gene Detail
Symbol

Name
ID
Ckmt2
creatine kinase, mitochondrial 2
MGI:1923972
Synonyms
2300008A19Rik, ScCKmit
Feature Type
protein coding gene
Genetic Map
Chromosome 13
47.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:91853387-91876885 bp, - strand
From VEGA annotation of GRCm38

  23499 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68206  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: CKMT2
Protein SuperFamily: creatine kinase
Gene Tree: Ckmt2

Human
homologs
CKMT2, creatine kinase, mitochondrial 2 (sarcomeric)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1160
neXtProt AC: NX_P17540

Human Synonyms: SMTCK

Human Chr (Location): 5q13.3; chr5:81233320-81266398 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
The hearts of mice homozygous for disruptions of this gene have hypertrophic and dilated left ventricles exhibit functional abnormalities.
 
Interactions
Ckmt2 interacts with 37 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process phosphocreatine metabolic process, phosphorylation
Component membrane, mitochondrial inner membrane, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (98)    Tissues (97)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 4
cDNA source data(47)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ckmt2a, ckmt2b    NEW 
Molecular
reagents
All nucleic(49) cDNA(47) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000029571 (Evidence)
Ensembl Gene Model ENSMUSG00000021622 (Evidence)
Entrez Gene 76722 (Evidence)
UniGene 316438
DFCI TC1579058, TC1731576
DoTS DT.492687, DT.91338717
NIA Mouse Gene Index U035018
EC 2.7.3.2
Consensus CDS Project CCDS26679.1
International Mouse Phenotyping Consortium Status Ckmt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029571 VEGA Gene Model | MGI Sequence Detail 23499 C57BL/6J ±  kb
transcript OTTMUST00000073334 VEGA | MGI Sequence Detail 1486 Not Applicable 
polypeptide OTTMUSP00000037934 VEGA | MGI Sequence Detail 419 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(185 from dbSNP Build 137)    SNPs within 2kb including multiple locations(187)
Protein-related
information
ResourceIDDescription
InterPro IPR000749 ATP:guanido phosphotransferase
InterPro IPR022415 ATP:guanido phosphotransferase active site
InterPro IPR022414 ATP:guanido phosphotransferase, catalytic domain
InterPro IPR022413 ATP:guanido phosphotransferase, N-terminal
InterPro IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
Protein Ontology PR:000005517 creatine kinase, sarcomeric mitochondrial
References
(Earliest) J:76700 Steeghs K, et al., Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell. 1997 Apr 4;89(1):93-103
(Latest) J:214478 Tanimura A, et al., Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation. PLoS One. 2014;9(2):e89916
All references(54)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory