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Kansl1 Gene Detail
Summary
  • Symbol
    Kansl1
  • Name
    KAT8 regulatory NSL complex subunit 1
  • Synonyms
    1700081L11Rik, mKIAA1267
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923969
    NCBI Gene: 76719
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:104224055-104359687 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 67.79 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923969
protein coding gene Chr11:104224055-104360584 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019275
protein coding gene Chr11:107480878-107629001 (-)
A/J MGP_AJ_G0019243
protein coding gene Chr11:102907001-103048143 (-)
AKR/J MGP_AKRJ_G0019212
protein coding gene Chr11:106052660-106193695 (-)
BALB/cJ MGP_BALBcJ_G0019217
protein coding gene Chr11:103340950-103477757 (-)
C3H/HeJ MGP_C3HHeJ_G0019026
protein coding gene Chr11:106290424-106433602 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019667
protein coding gene Chr11:110801385-110944900 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017292
protein coding gene Chr11:100314418-100443619 (-)
CAST/EiJ MGP_CASTEiJ_G0018580
protein coding gene Chr11:107343619-107491726 (-)
CBA/J MGP_CBAJ_G0018995
protein coding gene Chr11:115403079-115550362 (-)
DBA/2J MGP_DBA2J_G0019107
protein coding gene Chr11:102398873-102533690 (-)
FVB/NJ MGP_FVBNJ_G0019098
protein coding gene Chr11:101937168-102073115 (-)
LP/J MGP_LPJ_G0019176
protein coding gene Chr11:107952696-108103079 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019128
protein coding gene Chr11:114707165-114862829 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019704
protein coding gene Chr11:106448950-106596935 (-)
PWK/PhJ MGP_PWKPhJ_G0018344
protein coding gene Chr11:103498728-103638761 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018135
protein coding gene Chr11:106228594-106360071 (-)
WSB/EiJ MGP_WSBEiJ_G0018629
protein coding gene Chr11:106461252-106607895 (-)



Homology
more
  • Human Ortholog
    KANSL1, KAT8 regulatory NSL complex subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KANSL1, KAT8 regulatory NSL complex subunit 1
  • Synonyms
    CENP-36, hMSL1v1, KDVS, KIAA1267, MSL1v1, NSL1
  • Links
    NCBI Gene ID: 284058
    neXtProt AC: NX_Q7Z3B3
    UniProt: Q7Z3B3

  • Chr Location
    17q21.31; chr17:46029916-46225374 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KANSL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from multigenic genotypes
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018412 Ensembl Gene Model | MGI Sequence Detail 135633 C57BL/6J ±  kb
transcript ENSMUST00000106971 Ensembl | MGI Sequence Detail 5222 Not Applicable  
polypeptide ENSMUSP00000102584 Ensembl | MGI Sequence Detail 1099 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 169
    Genomic 1
    cDNA 168

    Microarray probesets 6
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:33331 Nishiguchi S, et al., A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996 Apr;119(4):749-67
  • Latest
    J:327464 Li T, et al., Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice. Nat Commun. 2022 Feb 17;13(1):931

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory